Study shows BICRA gene functions in neural development in humans, flies

Physicians and scientists are constantly on the lookout for new disease genes that can help them understand why patients have undiagnosed medical problems. Often the first clues come from genetic testing that reveals a change or mutation in a gene that they see in a child but not their parents.

This is exactly what led to a new study published today in the American Journal of Human Genetics.

A multidisciplinary group including researchers at Baylor College of Medicine, Dana-Farber Cancer Institute, and other institutions identified the BICRA gene as a new disease gene involved in a neurodevelopmental disorder and found evidence that BICRA functions in neural development in humans and flies.

The findings provide answers to families and reveal to physicians and scientists new insights into how BICRA works, allowing for the development of individualized medical plans for patients in the future.

BICRA mutations are associated with human neurodevelopmental disorders

The first patient the researchers identified presented with undiagnosed neurological defects, including neurodevelopmental delay and other features similar, but not identical, to those observed in Coffin-Siris syndrome patients. Genetic studies revealed that the patient carried a mutation in the BICRA gene.

"With the help of the online gene-matching tool GeneMatcher, the researchers found 11 more patients with similar conditions carrying BICRA gene variants," said co-corresponding author, Dr. Hugo Bellen, Distinguished Service Professor of Molecular and Human Genetics at Baylor and member of the Jan and Dan Neurological Research Institute at Texas Children's Hospital.

In all 12 cases, the BICRA mutations were new in the patients; they were not inherited from their parents. Some of the mutations led to the loss of function of the BICRA protein.

"Further analyses showed that BICRA mutations can cause disease in a dominant fashion - a mutation of only one of the two copies of the BICRA gene in the genome is sufficient to cause disease," said co-first author Dr. Scott Barish, a postdoctoral associate in the Bellen lab.

This work was performed in collaboration with the lab of Dr. Cigall Kadoch at Dana-Farber Cancer Institute and Harvard Medical School.

Zebrafish and fruit flies connect BICRA to neural development

To investigate the potential connection of the BICRA gene with the features observed in the patients, the researchers turned to zebrafish and fruit flies.

"We conducted the work with zebrafish in collaboration with the Undiagnosed Disease Network Zebrafish Core run by Dr. Monte Westerfield and Dr. John Postethwait at the University of Oregon. They made a mutation in the zebrafish version of BICRA that mimicked the mutation in one of the patients," Barish said. "The zebrafish carrying the mutation showed a craniofacial defect that was similar to the facial features observed in the patients."

"In fruit flies, we showed that BICRA is expressed in the nuclei of neurons and glia, both in the larval and adult brain," said Bellen, who also is an investigator at the Howard Hughes Medical Institute at Baylor.

Identifying BICRA as a disease gene may increase the speed at which other disease genes are identified."

Dr. Daryl Scott, Study Co-Corresponding Author, Associate Professor of Molecular and Human Genetics, Baylor College of Medicine

Source:
Journal reference:

Barish, S., et al. (2020) BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. American Journal of Human Genetics. doi.org/10.1016/j.ajhg.2020.11.003.

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