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Low oxygen environment protects brain and restores movement in mice with Parkinson's

Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment - similar to the thin air found at Mount Everest base camp - can protect the brain and restore movement in mice with Parkinson's-like disease.

6 Aug 2025

Apple snail eye regeneration offers new insights into human sight restoration

The eye of the apple snail is unusually similar to a human eye-but, unlike human eyes, it can regrow itself if injured or even amputated.

6 Aug 2025

HOXB13 emerges as a context-dependent regulator in cancer biology

HOXB13, a B-class homeobox transcription factor, sits at the hub of developmental gene networks yet has emerged as a double-edged sword in human cancer.

5 Aug 2025

Targeting lactate metabolism offers new avenues for cancer treatment

Lactic acid (LA) has transitioned from being perceived as a mere glycolytic waste product to a pivotal regulator of tumor-immune crosstalk.

5 Aug 2025

Researchers solve longstanding mystery of protein release in cells

It's known as biology's central dogma: All living organisms' genetic information is stored in DNA, which is transcribed into RNA, which is translated into proteins that perform nearly all essential tasks in a cell.

5 Aug 2025

Lupus Research Alliance awards early career scientists for innovative research

Today, the Lupus Research Alliance (LRA), the world's largest private funder of lupus research, announced the recipients of the 2025 Empowering Lupus Research (ELR) Career Development Award and Postdoctoral Award.

5 Aug 2025

T cells use glucose to strengthen tumor attacking signals

For cancer- and infection-fighting T cells, glucose offers far more than a simple sugar rush.

5 Aug 2025

Starfish compound overcomes drug resistance in prostate cancer models

Researchers identified that triterpene glycosides from the starfish Solaster pacificus can kill drug-resistant prostate cancer cells in vitro by bypassing common resistance pathways. CuC1 showed synergy with existing chemotherapies, though with only moderate selectivity for cancer cells.

5 Aug 2025

Understanding how long non-coding RNAs control gene expression in cancer

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed.

5 Aug 2025

Lipid droplet protein perilipin 2 linked to poor prognosis in lung cancer

New research has revealed that perilipin 2 protein modulates aggressive cancer progression in advanced lung adenocarcinoma, the most common type of lung cancer, by regulating lipid droplet accumulation, which plays an important role in lipid metabolism by making cancer cells store more fat, acting as a fuel source.

5 Aug 2025

Weight loss with ozempic may weaken muscles even when size remains stable

As use of the popular anti-diabetic and weight-loss drug Ozempic skyrockets, so have concerns about the medication's side effects.

5 Aug 2025

KAIST scientists achieve first total synthesis of herpotrichone with neuroprotective properties

"Herpotrichone" is a natural substance that has been evaluated highly for its excellent ability to suppress inflammation in the brain and protect nerve cells, displaying significant potential to be developed as a therapeutic agent for neurodegenerative brain diseases such as Alzheimer's disease and Parkinson's disease.

5 Aug 2025

PDGFRA+ progenitors identified as key players in angiogenesis and periodontal tissue repair

Stem cell research, alongside the rapidly advancing field of biotechnology, has led to remarkable innovations in regenerative medicine.

5 Aug 2025

Scaling organ‑chip technology for human‑relevant drug discovery

Discover how AVA brings scale and reproducibility to organ‑chip technology, enabling human‑relevant insights that accelerate drug discovery workflows.

From Emulate, Inc. 5 Aug 2025

AI model advances prediction of microsatellite status in cancer

One in every three people is expected to have cancer in their lifetime, making it a major health concern for mankind.

5 Aug 2025

Breakthrough study reveals potential treatment path for ALS

Amyotrophic lateral sclerosis (ALS), known as Lou Gehrig's disease, is an incurable neurological disorder affecting motor neurons-nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing.

5 Aug 2025

Gfi1 regulates exhausted CD8+ T cells to improve cancer immunotherapy

Killer immune cells destroy cancer cells and cells infected by virus. These CD8+ T cells are activated after detection of viral infection or growth of "non-self" tumor cells.

5 Aug 2025

Cannabis use disorder triples five-year risk of oral cancer

Research shows cannabis use disorder triples the risk of oral cancer, challenging perceptions of cannabis safety and prompting calls for health screenings.

5 Aug 2025

LptM protein revealed as essential to outer membrane stability in bacteria

Gram-negative bacteria pose a significant threat to global health due to their high resistance to antibiotics compared to that of Gram-positive bacteria.

4 Aug 2025

'Two-in-one' RNA molecule can simultaneously turn off two difficult-to-target cancer-related genes

University of North Carolina Lineberger Comprehensive Cancer Center researchers have developed a "two-in-one" molecule that can simultaneously turn off two notoriously difficult-to-target cancer-related genes, KRAS and MYC, as well as directly deliver drugs to tumors that express these genes.

4 Aug 2025