Clinical Trial News and Research

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Avastin increases tumor response rates in breast cancer patients before surgery

Amid the controversy surrounding the Food and Drug Administration's ruling that Avastin should no longer be used to treat metastatic breast cancer, a new multinational Phase III clinical trial shows that Avastin significantly increased tumor response rates in breast cancer patients when given before surgery.

24 Aug 2011

PerOral Endoscopic Myotomy holds promise for patients with esophageal achalasia

Jorge Sobenes is a husband and father who loves to cook for his family. In a nine month period however, he went from enjoying his favorite foods to not being able to eat or drink due to a tightening in his throat and difficulty swallowing. He lost 40 pounds and was desperate for answers. Sobenes was diagnosed with achalasia, a condition where the esophagus is unable to move food into the stomach, and was told he would need surgery. Historically, the procedure requires several incisions in the abdomen in order to access the blocked esophageal pathway.

24 Aug 2011

Craniofacial surgeons employ bipolar electrocautery to temporarily reshape the brain

Plastic surgeons say they have developed a new surgical technique for complex skull reconstruction that could improve functional and aesthetic outcomes in cases that have previously been deemed impossible or unsafe and left patients with unsightly skull deformities requiring them to wear a helmet.

24 Aug 2011

First North American clinical trial to test adult MSC transplantation as a new MS therapy

A team of researchers at three landmark Cleveland institutions have come together to launch a new clinical trial of an experimental treatment for multiple sclerosis.

24 Aug 2011

Seattle Genetics initiates ADCETRIS phase II trial in CD30-positive non-Hodgkin lymphoma

Seattle Genetics, Inc. today announced that it has initiated a phase II clinical trial of ADCETRIS for patients with relapsed or refractory CD30-positive non-Hodgkin lymphomas, including diffuse large B-cell lymphoma, peripheral T-cell lymphoma and other less common lymphoma subtypes.

24 Aug 2011

BioLineRx second quarter net loss decreases to NIS 16.4 million

BioLineRx Ltd., a biopharmaceutical development company, today reported its results for the second quarter ending June 30, 2011.

23 Aug 2011

itm FlowMedical initiates Rhenium-PTA therapy clinical trial in PAOD

itm FlowMedical GmbH announced the start of OPEN-188 clinical trial. It will compare itm Rhenium-PTA, a therapy for the prevention of restenosis in peripheral vessels, to a regular PTA, the standard therapy for the treatment of PAOD.

23 Aug 2011

Pearl selects TransPerfect's Trial Interactive eTMF solution for clinical development programs

TransPerfect today announced that Pearl Therapeutics has implemented TransPerfect's Trial Interactive electronic Trial Master File (eTMF) solution for the company's clinical development programs.

23 Aug 2011

Spinifex secures AU$6.25 million in expanded Series B funding

Spinifex Pharmaceuticals, an Australian pain drug development company, today announced it has secured a further AU$6.25 million of venture capital investment from GBS Venture Partners Limited, Brandon Capital Partners Pty Limited, Uniseed Management Pty Limited and UniQuest Pty Limited to fund the development of its pain management drug, EMA401.

23 Aug 2011

Aptiv Solutions acquires Medical Device Consultants

Aptiv Solutions announced today the acquisition of Medical Device Consultants, Inc. (MDCI), a provider of expert medical device consulting and clinical trial management and execution.

23 Aug 2011

OICR President announces $12.6M in funding for High Impact Clinical Trials Program

Dr. Tom Hudson, President and Scientific Director of the Ontario Institute for Cancer Research (OICR), today announced $12.6 million in funding over four years for OICR's High Impact Clinical Trials (HICT) Program.

23 Aug 2011

Symphogen initiates Sym004 Phase 2 trial in squamous cell carcinoma of head and neck cancer

Symphogen A/S today announced the initiation of a Phase 2 clinical trial to investigate the safety and efficacy of Sym004 in patients who have failed anti-EGFR monoclonal antibody (mAb)-based therapy, with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

23 Aug 2011

Living Cell Technologies xenoimplants first patients in Argentina trial

Living Cell Technologies Limited has implanted the first two patients taking part in a Phase II DIABECELL® clinical trial in Buenos Aires, Argentina.

22 Aug 2011

Scientists discover key defense mechanism against C. difficile infection

Researchers have discovered a key mechanism used by intestinal cells to defend themselves against one of the world's most common hospital-acquired bacterial infections - a mechanism they think they can exploit to produce a therapy to protect against the effects of the antibiotic-resistant bacteria.

22 Aug 2011

Wistar Institute, Graham Cancer Center enter research collaboration

Christiana Care Health System's Helen F. Graham Cancer Center and The Wistar Institute, an international leader in biomedical research, have entered into an historic partnership to collaborate on translational cancer research with the aim of bringing the latest discoveries in cancer research to cancer patients in the community.

20 Aug 2011

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

The U.S. Food and Drug Administration today approved Adcetris to treat Hodgkin lymphoma and a rare lymphoma known as systemic anaplastic large cell lymphoma.

20 Aug 2011

Amgen to present data from several Prolia studies at ASBMR 2011 meeting

Amgen today announced that it will present data from several Prolia (denosumab) studies, including eight year efficacy and safety data from a Phase 2 extension study in women with postmenopausal osteoporosis with low bone mineral density (BMD), at the 2011 American Society for Bone and Mineral Research (ASBMR) Annual Meeting in San Diego, Calif. from Sept. 16-20, 2011.

19 Aug 2011

NIH/NINDS awards AMRI to develop pre-clinical drug candidate for spinal muscular atrophy

AMRI today announced it received a federal contract award from the National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS) to provide chemistry and other drug discovery technologies in support of NINDS' Medicinal Chemistry for Neurotherapeutics Program (MCNP), part of the NIH Blueprint Neurotherapeutics Network.

19 Aug 2011

High blood phosphate levels can set CKD patients on a rapid path to kidney failure

High blood phosphate levels can set chronic kidney disease (CKD) patients on a rapid path to kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.

19 Aug 2011

Minocycline, EDTA may combat catheter-related bacterial infections in dialysis patients

Antibiotics can help ward off serious bacterial infections in kidney disease patients who use tubes called catheters for their dialysis treatments. But if antibiotics are used too often, "super bugs" may crop up that are resistant to the drugs.

19 Aug 2011

Clinical Trial News and Research

Avastin increases tumor response rates in breast cancer patients before surgery

PerOral Endoscopic Myotomy holds promise for patients with esophageal achalasia

Craniofacial surgeons employ bipolar electrocautery to temporarily reshape the brain

First North American clinical trial to test adult MSC transplantation as a new MS therapy

Seattle Genetics initiates ADCETRIS phase II trial in CD30-positive non-Hodgkin lymphoma

BioLineRx second quarter net loss decreases to NIS 16.4 million

itm FlowMedical initiates Rhenium-PTA therapy clinical trial in PAOD

Pearl selects TransPerfect's Trial Interactive eTMF solution for clinical development programs

Spinifex secures AU$6.25 million in expanded Series B funding

Aptiv Solutions acquires Medical Device Consultants

OICR President announces $12.6M in funding for High Impact Clinical Trials Program

Symphogen initiates Sym004 Phase 2 trial in squamous cell carcinoma of head and neck cancer

Living Cell Technologies xenoimplants first patients in Argentina trial

Scientists discover key defense mechanism against C. difficile infection

Wistar Institute, Graham Cancer Center enter research collaboration

Seattle Genetics receives FDA approval for Adcetris to treat Hodgkin lymphoma, ALCL

Amgen to present data from several Prolia studies at ASBMR 2011 meeting

NIH/NINDS awards AMRI to develop pre-clinical drug candidate for spinal muscular atrophy

High blood phosphate levels can set CKD patients on a rapid path to kidney failure

Minocycline, EDTA may combat catheter-related bacterial infections in dialysis patients

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