Protein C News and Research

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Preeclampsia-related placental gene expression may be associated with vitamin D status

According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies. It can cause serious, sometimes fatal, complications in the mother and child.

10 Nov 2020

Exosome-mediated mRNA delivery generates broad immune response to multiple SARS-CoV-2 proteins

Recently, researchers from The Johns Hopkins University School of Medicine, Baltimore, MD, USA, and Capricor Therapeutics, Inc., Beverly Hills, CA, USA, described a new approach to SARS-CoV-2 vaccine development using exosomes to deliver mRNAs that encode the antigens from multiple structural proteins of the virus.

9 Nov 2020

Research explores links between Alzheimer's and Parkinson′s to COVID-19

In a recent medRxiv* preprint paper, Dr. L. Miguel Martins and colleagues from the University of Cambridge investigate the links between neurodegeneration and COVID-19.

9 Nov 2020

WPI researchers awarded NIH funding to develop computational models for human cell division

Two researchers at Worcester Polytechnic Institute have been awarded $917,999 by the National Institutes of Health to develop computational models for the study of a critical piece of cellular machinery that often goes awry in cancer.

9 Nov 2020

Research uncovers key to piercing dangerous bacteria's armor

Bacteria are single-celled organisms that are essential to human health, both in our environment and inside our own bodies. However, certain bacterial species can make us sick.

9 Nov 2020

Promising yeast-expressed SARS-CoV-2 vaccine candidate effective in mice

Researchers at the Texas Children's Hospital Center for Vaccine Development, USA, have published a report on the preprint server bioRxiv that describes a yeast-expressed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) protein, a key target of current vaccine development efforts.

9 Nov 2020

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

A recent study published on the preprint server bioRxiv in October 2020 shows what the protein translation process looks like in specific terms. In doing so, the study has provided new insights that might prove helpful in developing new therapies for COVID-19 patients.

9 Nov 2020

ACE2 and TMPRSS2 not the only virus-receptors to mediate SARS-CoV-2 entry

However, a recent study published on the preprint server bioRxiv in November 2020 uncovers the major role played by the N-terminal domain of the SARS-CoV-2 virus in host infection. This could be of great use in measuring the usefulness of antibodies used in convalescent plasma therapy for COVID-19.

9 Nov 2020

Immune-evading variants can emerge in SARS-CoV-2, researchers warn

An international team of researchers has shown that a mutation within severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus disease 2019 (COVID-19) – enables the pathogen to evade antibody-mediated immunity while maintaining replication fitness and increasing viral loads.

9 Nov 2020

Skipping breakfast and late dinner may be linked with higher risk of proteinuria

The relationship between dietary habits and the occurrence of chronic kidney disease (CKD) is not fully known. In a new study, researchers from Kanazawa University found out that skipping breakfast and late dinner might be associated with a higher risk of proteinuria which is a key prognostic factor of CKD.

9 Nov 2020

Study shows oxidant hydrogen peroxide can actually slow down cell ageing

At high concentrations, reactive oxygen species - known as oxidants - are harmful to cells in all organisms and have been linked to ageing.

9 Nov 2020

National Covid-19 Resilience Programme in the UK would support older people through pandemic

Public health agencies across the UK should launch a National Covid-19 Resilience Programme to support older people through the pandemic and to keep them healthy and resilient over the winter - that's the recommendation from a leading group of scientists and clinicians working in the fields of physiology, nutrition and physiotherapy.

9 Nov 2020

Researchers identify new strategy to combat loss of skeletal muscle mass

Researchers at the University of São Paulo (USP) in Brazil have shown for the first time that stimulating expression of a protein naturally produced by the human body can be a strategy to combat loss of skeletal muscle mass, which happens normally with aging but can intensify in cases of neurodegenerative or inflammatory disease, or in patients who spend long periods in intensive care units (ICUs).

9 Nov 2020

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

SARS-CoV-2, the respiratory virus that causes COVID-19, attacks the body in multiple steps. Gaining entry into cells deep within the lungs and hijacking the human host cell's machinery to churn out copies of itself are two of the earliest steps -- both essential for viral infection.

9 Nov 2020

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Researchers at the Francis Crick Institute and University College London have found that some antibodies, created by the immune system during infection with common cold coronaviruses, can also target SARS-CoV-2 and may confer a degree of protection against the new viral strain.

9 Nov 2020

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed photoresponsive derivatives of the anticancer drug Taxol, which allow light-based control of cytoskeleton dynamics in neurons. The agents can optically pattern cell division and may elucidate how Taxol acts.

9 Nov 2020

Researchers to develop new optogenetic tools for biology and medicine

The European Research Council (ERC) is providing 10 million euros in funding for an interdisciplinary, collaborative project in the structural and biophysical analysis of selected photoreceptors and their development into "OptoGPCRs", light-controlled molecular switches with a wide range of applications in biology and medicine.

8 Nov 2020

Study shows SARS-CoV-2 direct heart muscle cell infection, cell death, loss of contractility

In the study, published on the pre-print journal bioRxiv, the researchers revealed that SARS-CoV-2-infected EHTs manifested the typical characteristics of myocarditis or heart inflammation. These include the stimulation of immune cells, heart cell death, and decreased contractile force generation.

8 Nov 2020

SARS-CoV-2 antibodies wane, depending on age, symptoms and ethnicity

Researchers at the University of Oxford have conducted a study of UK healthcare workers showing how antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can wane over time, depending on age, previous symptoms and ethnicity.

8 Nov 2020

SARS-CoV-2 viral antigens found in non-pulmonary tissues in recovering patients

A team of researchers in Singapore, led by Dr. Joe Yeong, and Prof. Tony Kiat Hon Lim, have reported the presence of residual SARS-CoV-2 ribonucleic acid (RNA) – the virus' genetic material – in stool samples and gastrointestinal tissues from patients recovering from the coronavirus disease 2019 (COVID-19).

8 Nov 2020

Protein C News and Research

Preeclampsia-related placental gene expression may be associated with vitamin D status

Exosome-mediated mRNA delivery generates broad immune response to multiple SARS-CoV-2 proteins

Research explores links between Alzheimer's and Parkinson′s to COVID-19

WPI researchers awarded NIH funding to develop computational models for human cell division

Research uncovers key to piercing dangerous bacteria's armor

Promising yeast-expressed SARS-CoV-2 vaccine candidate effective in mice

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

ACE2 and TMPRSS2 not the only virus-receptors to mediate SARS-CoV-2 entry

Immune-evading variants can emerge in SARS-CoV-2, researchers warn

Skipping breakfast and late dinner may be linked with higher risk of proteinuria

Study shows oxidant hydrogen peroxide can actually slow down cell ageing

National Covid-19 Resilience Programme in the UK would support older people through pandemic

Researchers identify new strategy to combat loss of skeletal muscle mass

New strategy for designing COVID-19 antiviral drugs to inhibit key viral protein

Pre-existing antibodies created during COVID-19 may protect children against new pandemic strain

Study: Photoresponsive derivatives of Taxol allow light-based control of microtubule cytoskeleton

Researchers to develop new optogenetic tools for biology and medicine

Study shows SARS-CoV-2 direct heart muscle cell infection, cell death, loss of contractility

SARS-CoV-2 antibodies wane, depending on age, symptoms and ethnicity

SARS-CoV-2 viral antigens found in non-pulmonary tissues in recovering patients

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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