Clinical Trial News and Research

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GTx commences Capesaris Phase IIb trial in advanced prostate cancer

GTx, Inc., announced today that it initiated a Phase IIb clinical trial evaluating Capesaris, a selective estrogen receptor alpha agonist, compared to Lupron Depot for first line treatment of advanced prostate cancer.

20 Jun 2011

Alexion begins eculizumab clinical trial in Shiga-toxin producing E. coli hemolytic uremic syndrome

Alexion Pharmaceuticals, Inc. and Alexion Pharma International Sàrl (APIS), announced today that the Paul-Ehrlich-Institut, Germany's healthcare regulatory body for biological products, has authorized initiation of an open-label clinical trial to investigate eculizumab as a treatment for patients with Shiga-toxin producing E. coli hemolytic uremic syndrome, which has resulted from infections by Enterohemorrhagic Escherichia coli in an unusually wide outbreak in Germany that began in May.

20 Jun 2011

Surgeons demonstrate potential genetic basis for varying outcomes of leg vein bypass surgery

Vascular Cures, a leading non-profit investing in research to develop breakthrough treatments for vascular disease, announced results that indicate there may be a genetic basis for the varying outcomes of bypass surgery in the legs.

20 Jun 2011

Genentech to present positive data from vismodegib Phase II trial on advanced BCC at EADO 2011

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that positive data are being presented by its collaborator Genentech, a member of the Roche Group, from a pivotal Phase II clinical trial conducted by Roche and Genentech of vismodegib in patients with advanced basal cell carcinoma, an often life-threatening form of skin cancer that can have disfiguring and debilitating effects.

20 Jun 2011

Patients still being enrolled in clinical trial for new peripheral vascular disease treatment

The first three patients to undergo an investigational surgical procedure for peripheral vascular disease that involves the patient's own stem cells continue to do well, reports the University of Louisville surgeon who is the principal investigator.

18 Jun 2011

Niclosamide drug effective against colon cancer metastasis

A compound that for about 60 years has been used as a drug against tapeworm infection is also apparently effective against colon cancer metastasis, as studies using mice have now shown.

18 Jun 2011

Positive data from Ischemix CMX-2043 Phase 2a trial for peri-operative cardiac ischemia-reperfusion injury

Ischemix today announced positive top line data from a Phase 2a clinical trial of CMX-2043 for the prevention of peri-operative cardiac ischemia-reperfusion injury.

17 Jun 2011

VIVUS Avanafil phase 3 trial on erectile dysfunction meets primary endpoints

VIVUS, Inc. today announced that the positive results from REVIVE-RP, a phase 3 clinical trial evaluating the safety and efficacy of the investigational drug avanafil for the treatment of erectile dysfunction (ED),will be presented this afternoon at the 2011 Cancer Survivorship and Sexual Health Symposium in Washington D.C.

17 Jun 2011

Experimental vaccine shows promise for patients with newly diagnosed brain tumors

An experimental vaccine developed by researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute targets overactive antigens in highly aggressive brain tumors and improves length of survival in newly diagnosed patients, according to new data that was presented in a poster session at the 47th Annual Meeting of the American Society of Clinical Oncology.

17 Jun 2011

Positive results from etanercept pilot study against dermatomyositis

A multicenter pilot study of etanercept for treatment of dermatomyositis found no major safety concerns and many patients treated with the drug were successfully weaned from steroid therapy.

17 Jun 2011

BioClinica releases new Trident IWR solution

BioClinica, Inc., a global provider of clinical trial management solutions, today announced a new release of Trident IWR, the latest addition to its best-in-class suite of eClinical applications.

From Clario 17 Jun 2011

Adaptimmune melanoma trial opening

Adaptimmune announced today that it has opened a Phase I/II, two cohort, open label clinical trial in metastatic melanoma at Washington University, St. Louis, Missouri.

16 Jun 2011

Low testosterone linked to varicoceles

As many as 15 percent of men have varicoceles, masses of enlarged and dilated veins in the testicles. There is new evidence that varicoceles, long known to be a cause of male infertility, interfere with the production of testosterone -- a crucial hormone to maintaining men's health. There is good news too: Microsurgery can increase testosterone levels in these men. Results of new research by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center are in a recent edition of BJU International.

16 Jun 2011

Theorem Clinical Research receives contract to conduct Nordion's TheraSphere Phase III trials

Nordion Inc., a leading provider of products and services to the global health science market, today announced that Theorem Clinical Research, previously Omnicare Clinical Research, a full service Contract Research Organization has been awarded the contract to conduct Nordion's recently announced TheraSphere Phase III clinical trials for the treatment of primary and metastatic liver cancers - STOP-HCC and EPOCH.

16 Jun 2011

Tulane University, VA grant IRB approval for new TIGR Matrix clinical trial in hernia repair

Novus Scientific today announced that Tulane University School of Medicine and Department of Veterans Affairs have granted IRB approval to a new trial: A Study Evaluating Efficacy of TIGR® Matrix Surgical Mesh used in Elective Open Inguinal Hernia Repair.

16 Jun 2011

Large trial of tenofovir gel for women set to begin in South Africa

A 24-month clinical trial looking at the effectiveness of tenofovir gel use among women to reduce the risk of HIV infection is set to begin in South Africa in late July or early August, the Mail & Guardian reports.

16 Jun 2011

Positive results from BiondVax Multimeric-001 Phase IIa trial against influenza

BiondVax Pharmaceuticals Ltd. today announced positive results from its first Phase II clinical trial of the Multimeric-001 Universal Influenza Vaccine.

16 Jun 2011

Seattle Genetics brentuximab vedotin, dacetuzumab clinical data to be presented at ICML 2011

Seattle Genetics, Inc. today announced that data from its brentuximab vedotin and dacetuzumab programs will be presented at the 11th International Conference on Malignant Lymphoma being held June 15-18, 2011 in Lugano, Switzerland.

16 Jun 2011

Inviragen commences INV21 Phase 1 trial against Hand, Foot and Mouth Disease

Inviragen announced today the initiation of the first clinical trial of the Company's proprietary Hand, Foot and Mouth Disease (HFMD) investigational vaccine, INV21, a highly purified virus particle preparation designed to protect against HFMD caused by enterovirus 71.

16 Jun 2011

HTX provides $750,000 funding to Profound Medical through Technology Assessment Program

HTX, a member of the Canadian Venture Capital Association, announced today it provided $750,000 in financing to Profound Medical Inc. through their Technology Assessment Program.

15 Jun 2011

Clinical Trial News and Research

GTx commences Capesaris Phase IIb trial in advanced prostate cancer

Alexion begins eculizumab clinical trial in Shiga-toxin producing E. coli hemolytic uremic syndrome

Surgeons demonstrate potential genetic basis for varying outcomes of leg vein bypass surgery

Genentech to present positive data from vismodegib Phase II trial on advanced BCC at EADO 2011

Patients still being enrolled in clinical trial for new peripheral vascular disease treatment

Niclosamide drug effective against colon cancer metastasis

Positive data from Ischemix CMX-2043 Phase 2a trial for peri-operative cardiac ischemia-reperfusion injury

VIVUS Avanafil phase 3 trial on erectile dysfunction meets primary endpoints

Experimental vaccine shows promise for patients with newly diagnosed brain tumors

Positive results from etanercept pilot study against dermatomyositis

BioClinica releases new Trident IWR solution

Adaptimmune melanoma trial opening

Low testosterone linked to varicoceles

Theorem Clinical Research receives contract to conduct Nordion's TheraSphere Phase III trials

Tulane University, VA grant IRB approval for new TIGR Matrix clinical trial in hernia repair

Large trial of tenofovir gel for women set to begin in South Africa

Positive results from BiondVax Multimeric-001 Phase IIa trial against influenza

Seattle Genetics brentuximab vedotin, dacetuzumab clinical data to be presented at ICML 2011

Inviragen commences INV21 Phase 1 trial against Hand, Foot and Mouth Disease

HTX provides $750,000 funding to Profound Medical through Technology Assessment Program

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