Immune System News and Research

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Italian researcher sheds light on the lasting psychiatric impact of childhood trauma

In a revealing Genomic Press Interview published today in Brain Medicine, Sara Poletti, PhD, senior researcher at IRCCS Ospedale San Raffaele Milan, illuminates the profound connections between childhood adversity and lifelong vulnerability to psychiatric disorders through persistent neuroinflammation pathways and alterations in brain structure.

11 Jun 2025

Eva1 targeted CAR T cells successfully eliminate tumors in preclinical study

CAR-T cells are specialized immune cells genetically modified to recognize and attack cancer cells. Researchers at Nagoya University in Japan and their collaborators have developed new CAR-T cells to target malignant tumors.

11 Jun 2025

Study reveals a unique vulnerability in melanoma patients with neurofibromin 1 mutations

Increased activity in a specific biological pathway may explain why many patients with a deadly form of skin cancer do not respond to the latest cancer treatments, a new study shows.

10 Jun 2025

COVID boosters do not harm T-cell function in the vulnerable

Findings indicate that frequent COVID-19 booster shots do not weaken T-cell responses, alleviating concerns for vulnerable groups facing new variants.

9 Jun 2025

Study reveals mechanisms behind antibiotic-related immune disruptions in infants

In 2017, scientists at Cincinnati Children's revealed that using antibiotics to protect newborns from dangerous infections often comes with a long-term consequence-a permanently underdeveloped immune system that can make children prone to poor outcomes from future lung infections.

9 Jun 2025

Glycan mapping reveals what keeps the vaginal microbiome healthy

Glycan-bacteria binding profiles in the vaginal microbiome provide insights into reproductive health, highlighting targets for infection prevention strategies.

9 Jun 2025

Study offers new insights into how the body clears dead cells during stress

A new study from The University of Texas at Arlington details a novel strategy for how the body clears out dead cells during stress, revealing unexpected roles for well-known stress-response genes-a discovery that could help scientists better understand diseases affecting the immune system, brain and metabolism.

9 Jun 2025

Glioblastoma patients live longer with triple treatment strategy

A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments.

9 Jun 2025

Accelerated biological aging found in children with multiple sclerosis

Researchers from University of California San Diego School of Medicine have discovered that children living with multiple sclerosis (MS) show signs of accelerated biological aging, even in their teenage years.

9 Jun 2025

Scientists unlock potential of cytokine adjuvants in mRNA vaccines

In the quest to design vaccines that better help the body's immune system fight disease, scientists are always looking for more tools for their arsenal.

6 Jun 2025

New technique creates multimeric aptamers for precision virus targeting

We have all heard of antibodies – proteins produced by our bodies to bind to viruses or bacteria, marking them for elimination by the immune system.

6 Jun 2025

Study aims to demystify the immune toxicity triggered by osimertinib-ICI co-treatment

Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and remains a leading cause of cancer mortality worldwide.

6 Jun 2025

Oncologists push for age inclusive use of cancer treatments

Recent advances have resulted in highly effective "tissue-agnostic" drugs that treat cancers based on their molecular markers rather than their tissue of origin, but very few of these drugs are approved for use in children.

6 Jun 2025

Statins linked to lower death rates in critically ill sepsis patients

Sepsis is when the immune system overshoots its inflammatory reaction to an infection, so strongly that the vital organs begin to shut down.

6 Jun 2025

Breakthrough drug delivery system transports genetic therapies directly to the lungs

Scientists have made a key breakthrough for treating respiratory diseases by developing a new drug delivery system that transports genetic therapies directly to the lungs, opening promising possibilities for patients with conditions like lung cancer and cystic fibrosis.

5 Jun 2025

New biological age clock estimates how well someone is aging

A team of international researchers has developed a new biological age "clock" that estimates how well someone is aging, not just how "old" they or their various organs might be.

5 Jun 2025

Loss of Y chromosome in male immune cells linked to poorer cancer outcomes

A study initiated by a University of Arizona Comprehensive Cancer Center physician-scientist defined for the first time how loss of the Y chromosome in male immune cells negatively affects immune system function, which may explain why loss of Y is associated with lower cancer survival rates.

5 Jun 2025