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Scientists discover key age-related biological shifts at 40 and 60

Researchers uncover the nonlinear dynamics of aging, revealing significant biological shifts at ages 40 and 60, offering new insights into age-related diseases.

16 Aug 2024

Saliva test offers hope for head and neck cancer patients

But what if a mouthwash-based test to detect biomarkers can help physicians predict disease recurrence in head and neck cancer patients?

16 Aug 2024

Breakthrough in understanding cell communication during inflammation

Indiana University School of Medicine researchers have made significant progress in understanding how cells communicate during inflammation.

14 Aug 2024

Ketogenic diet can boost efficacy of pancreatic cancer therapy

A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.

14 Aug 2024

Breakthrough in synthesizing complex plant molecules

MIT chemists have developed a new way to synthesize complex molecules that were originally isolated from plants and could hold potential as antibiotics, analgesics, or cancer drugs.

14 Aug 2024

Scientists awarded $7.7 million grant to develop treatment for rare brain disorder

Children born with a damaged gene needed for healthy brain development, SYNGAP1, experience seizures, sensory processing disorders, difficulty speaking, intellectual disability, and autism-like behaviors.

13 Aug 2024

Higher heme iron intake linked to increased risk of type 2 diabetes

Higher intake of heme iron, the type found in red meat and other animal products - as opposed to non-heme iron, found mostly in plant-based foods - was associated with a higher risk of developing type 2 diabetes (T2D) in a new study led by researchers at Harvard T.H. Chan School of Public Health.

13 Aug 2024

Human dopamine transporter structure with cocaine revealed, unlocking addiction insights

Researchers have resolved the high-resolution structure of the human dopamine transporter bound to cocaine, providing critical insights into the molecular basis of cocaine's addictive properties.

12 Aug 2024

Beyond neurons: Glial cells identified as key players in Alzheimer's disease

Memory loss, confusion, speech problems – Alzheimer's disease is the most common cause of dementia, affecting about 35 million people worldwide, and the number is growing.

12 Aug 2024

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Most people wouldn't think twice after seeing sugar spilled on a counter. But for someone with a history of cocaine use, this visual cue could trigger powerful associations with their past drug use and a compulsive urge to seek the drug.

9 Aug 2024

Controllable chiral switching in double-helical foldamers for advanced molecular systems

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands.

9 Aug 2024

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Our skin–the body's largest organ–provides the first line of defense against infections and many other threats to our health.

9 Aug 2024

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene's code affect health.

9 Aug 2024

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells.

8 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Molecule News and Research

Scientists discover key age-related biological shifts at 40 and 60

Saliva test offers hope for head and neck cancer patients

Breakthrough in understanding cell communication during inflammation

Ketogenic diet can boost efficacy of pancreatic cancer therapy

Breakthrough in synthesizing complex plant molecules

Scientists awarded $7.7 million grant to develop treatment for rare brain disorder

Higher heme iron intake linked to increased risk of type 2 diabetes

Human dopamine transporter structure with cocaine revealed, unlocking addiction insights

Beyond neurons: Glial cells identified as key players in Alzheimer's disease

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Controllable chiral switching in double-helical foldamers for advanced molecular systems

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Breakthrough molecule reverses Alzheimer's symptoms

Nasal microbiome composition influences how well multi-resistant bugs can thrive in the nose

How social drinking and dopamine influence alcohol-induced euphoria in fruit flies

New target identified for melanoma resistant to current therapies

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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