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New electrically conductive hydrogel scaffold supports neural cell differentiation

Brain-computer interfaces (BCIs) are a hot topic these days, with companies like Neuralink racing to create devices that connect humans' brains to machines via tiny implanted electrodes.

5 Jan 2023

Sugar appears to play a role in polycystic kidney disease, study finds

A study of kidney organoids in a novel lab environment might have downstream implications for the treatment of polycystic kidney disease (PKD), an incurable condition that affects more than 12 million people worldwide.

5 Jan 2023

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

Researchers presented a microbody recombinant decoy protein with high affinity to angiotensin-converting enzyme 2 (ACE2) as an option for coronavirus disease 2019 (COVID-19) treatment.

5 Jan 2023

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Announcing a new publication for Acta Materia Medica journal. Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly every stage of the preclinical drug research and development (R&D) pipeline, and even to the early phase of clinical pharmaceutical evaluation.

3 Jan 2023

Why do some people develop persistent lung sequelae after severe COVID-19?

Clinical presentation following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild self-limiting illness to severe respiratory failure. Many studies have analyzed the early acute phases of coronavirus disease 2019(COVID-19), but few focused on the longer-term sequelae following infection.

2 Jan 2023

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

As a chronic pro-inflammatory disease, obesity is closely associated with the development of various diseases such as type 2 diabetes, cardiovascular disease and cancers. Obesity is now a major concern for public health.

30 Dec 2022

Researchers unravel how cells use their sense of touch to make decisions during embryogenesis

A research team at the Cluster of Excellence Physics of Life of TU Dresden and the University of California, Santa Barbara, reveals how cells sense their mechanical environment as they build tissues during embryogenesis.

28 Dec 2022

New Bio Ware device provides better results when used alongside exposure therapy for PTSD

Sights, smells and sounds of everyday life can supply the triggers that take someone with PTSD right back to the scarring scene they're trying to forget.

28 Dec 2022

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Insilico Medicine ("Insilico"), a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that the company's drug discovery team has nominated a preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy utilizing its end-to-end Pharma.AI platform.

27 Dec 2022

Researchers present a new strategy for self-adjuvanting vaccine development

This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development.

23 Dec 2022

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Researchers described a messenger ribonucleic acid (mRNA)-lipid nanoparticle monkeypox vaccine encoding four conserved monkeypox virus surface proteins which induced monkeypox virus-specific immunity and elicited heterologous protection when challenged with lethal vaccinia virus.

23 Dec 2022

Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

In order to treat patients with diabetes in the best possible way it is necessary to understand the disease mechanism. MODY type 3 (MODY3) is a monogenic hereditary form of diabetes, that is caused by a genetic defect in the HNF1A gene.

22 Dec 2022

Wearable skin patch could help clinicians diagnose tumors, organ malfunction and more

Novel skin patch capable of deep detection of hemoglobin and core temperature.

22 Dec 2022

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

A new study in mice has helped illuminate how the brain's primary motor cortex (M1) – a brain region most commonly associated with control of motor functions – helps suppress dimensions of neuropathic pain.

22 Dec 2022

Using the gut microbiome to understand and treat respiratory diseases

Researchers review the role of the gut microbiome in certain respiratory diseases.

22 Dec 2022

Machine learning used to generate a new holistic model for coronary artery disease

A recent study published in the Lancet journal investigated whether a quantitative in-silico score for coronary artery disease (ISCAD), based on a machine learning model, can be used as a clinical marker to detect coronary artery disease.

21 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

First cell-type specific multiomic study of the HIV brain

Researchers identify cell-type-specific differences in HIV integration sites in the brain.

19 Dec 2022

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Researchers from Paul Scherrer Institute PSI and ETH Zurich have discovered how proteins in the cell can form tiny liquid droplets that act as a smart molecular glue.

19 Dec 2022

Developing stem cell sheet for enhancement of angiogenesis which promotes cardiac repair

Myocardial infarction is an ischemic disease in which a coronary artery supplying blood to the heart muscle is stenotic or obstructed, resulting in cardiac tissue necrosis.

16 Dec 2022

in vivo News and Research

New electrically conductive hydrogel scaffold supports neural cell differentiation

Sugar appears to play a role in polycystic kidney disease, study finds

Study shows angiotensin-converting enzyme 2 decoy protein as a promising anti-SARS-CoV-2 agent

Technical advances expand the application of mass spectrometry imaging in pharmaceutical research

Why do some people develop persistent lung sequelae after severe COVID-19?

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

Researchers unravel how cells use their sense of touch to make decisions during embryogenesis

New Bio Ware device provides better results when used alongside exposure therapy for PTSD

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Researchers present a new strategy for self-adjuvanting vaccine development

Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

Wearable skin patch could help clinicians diagnose tumors, organ malfunction and more

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

Using the gut microbiome to understand and treat respiratory diseases

Machine learning used to generate a new holistic model for coronary artery disease

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

First cell-type specific multiomic study of the HIV brain

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Developing stem cell sheet for enhancement of angiogenesis which promotes cardiac repair

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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