Protein C News and Research

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MD65 IgG-YTE shows powerful post-exposure neutralization of SARS-CoV-2

A recent study published in the preprint server bioRxiv in October 2020 describes a reliable animal model to demonstrate the powerful capacity of human neutralizing mAbs directed against SARS-CoV-2 to prevent viral binding the host cell receptor and thus block infection. This indicates the lifesaving value of mAbs in severe COVID-19.

29 Oct 2020

Moscow scientists discover and explain the activity mechanism of new anti-cancer molecule

A group of Moscow scientists has discovered and explained the activity mechanism of a new anti-cancer molecule -- diphenylisoxazole.

29 Oct 2020

COVID-19 patients at risk of fatal co-infection during ICU stays

Researchers in the UK have conducted a study showing that a high proportion of patients admitted to intensive care units (ICU) with coronavirus disease 2019 (COVID-19) acquire a secondary bacterial co-infection during their hospital stay.

29 Oct 2020

UH and CWRU announce Phase 3 trial of Astrazeneca's investigational COVID-19 vaccine

University Hospitals and Case Western Reserve University announced today that UH Cleveland Medical Center has been selected as a clinical trial site for the Phase 3 global study of an investigational vaccine against SARS-CoV-2, sponsored by AstraZeneca.

29 Oct 2020

Intercellular communication pathway drives motivation to seek cocaine

In the October 28, 2020 issue of the Journal of Neuroscience, researchers from the Medical University of South Carolina and the National Institutes of Health describe how reminders of drug use can change specific brain cells responsible for motivation, increasing the desire to seek drugs.

29 Oct 2020

Simple diagnostic can help deliver urgent treatment to people at risk of dying from rapid blood loss

Engineers at Monash University in Australia have developed a fast, portable and cheap diagnostic that can help deliver urgent treatment to people at risk of dying from rapid blood loss.

29 Oct 2020

Tumor suppressor gene represses 'jumping genes'

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or "jumping genes," from hopping around the human genome.

29 Oct 2020

Protein tenascin-C plays a role in glaucoma by regulating inflammatory processes

Researchers at Ruhr-Universität Bochum have studied the role of the immune response in the development of glaucoma in mice.

29 Oct 2020

Study sheds new light on cell division fidelity, can impact future regenerative medicine

Researchers discover that a specialized part of the chromosomes, essential for a correct cell division, is smaller and weaker in stem cells, when compared to the ones of differentiated cells.

29 Oct 2020

New method could help increase effectiveness of vaccines against coronavirus

A University at Buffalo-led research team has discovered a technique that could help increase the effectiveness of vaccines against the novel coronavirus, the virus that causes COVID-19.

29 Oct 2020

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

Cell biologists at the University of Illinois at Urbana-Champaign and Bar-Ilan University at Israel and a bioimaging expert at the University of Central Florida are teaming up in what they hope may lead to a major breakthrough in understanding of the three-dimensional organization of the nucleus over time and their role in certain diseases.

29 Oct 2020

Majority of people infected with mild-to-moderate COVID 19 mount robust antibody response

The vast majority of individuals infected with mild-to-moderate COVID 19 mount a robust antibody response that is relatively stable for at least five months, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 28, in the journal Science.

29 Oct 2020

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

A key hurdle in treating breast cancers is intratumoral heterogeneity, or the presence of multiple different cell populations within the same tumor that have distinct characteristics such as gene expression, metabolism and ability to divide, spread and grow.

29 Oct 2020

Mouth may be primary route of SARS-CoV-2 infection and transmission

A new study published on the preprint server medRxiv in October 2020 shows that the virus also multiplies robustly in the oral cavity, indicating that saliva plays a role in viral transmission.

29 Oct 2020

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

Tangles of misfolded tau proteins in the brain are closely associated with memory loss in patients with Alzheimer's disease. In order for this tau pathology to spread, the protein must interact with heparan sulfate, a sugar molecule found on the surface of neurons.

28 Oct 2020

High-sugar diet can damage the gut’s protective mucus layer, lead to worse colitis

Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut's protective mucus layer.

28 Oct 2020

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

By leveraging nucleotide triphosphate analog-induced cell death, Chinese researchers unveiled genes that affect the import, export, and metabolism of pervasively used antiviral drugs in the treatment of coronavirus disease (COVID-19). This exciting study is currently available on the bioRxiv* preprint server.

28 Oct 2020

Protein C News and Research

MD65 IgG-YTE shows powerful post-exposure neutralization of SARS-CoV-2

Moscow scientists discover and explain the activity mechanism of new anti-cancer molecule

COVID-19 patients at risk of fatal co-infection during ICU stays

UH and CWRU announce Phase 3 trial of Astrazeneca's investigational COVID-19 vaccine

Intercellular communication pathway drives motivation to seek cocaine

Simple diagnostic can help deliver urgent treatment to people at risk of dying from rapid blood loss

Tumor suppressor gene represses 'jumping genes'

Protein tenascin-C plays a role in glaucoma by regulating inflammatory processes

Study sheds new light on cell division fidelity, can impact future regenerative medicine

New method could help increase effectiveness of vaccines against coronavirus

Cell biologists and bioimaging expert team up to solve fourth dimension secrets

Majority of people infected with mild-to-moderate COVID 19 mount robust antibody response

Study: Mammary basal cell lineage contributes to breast cancer heterogeneity

Mouth may be primary route of SARS-CoV-2 infection and transmission

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

High-sugar diet can damage the gut’s protective mucus layer, lead to worse colitis

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

A systematic review and meta-analysis of stroke in COVID-19 patients

Glucose-lowering drug can protect the kidneys in patients with type 1 diabetes, study shows

Deep learning models help hunt for COVID-19 drugs

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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