Clinical Trial News and Research

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Preliminary results from Generex Oral-lyn clinical trial on type 1 diabetes

Generex Biotechnology Corporation today announced preliminary clinical results of two major trials using the Generex Oral-lyn formulation that will be used for registration and marketing.

11 Jul 2011

EU countries should pool funding to create 'prize' for bringing new antibiotics to market, report says

"European policy makers were urged Wednesday to find viable financial incentives to get drug companies to discover new antibiotics, because the lack of fresh supplies poses acute dangers to health care and efforts against infectious diseases," according to a report by the Office of Health Economics and funded by GlaxoSmithKline, Dow Jones/Wall Street Journal reports.

8 Jul 2011

Merck decides not to advance IMO-2055 development for squamous cell carcinoma of the head and neck

Idera Pharmaceuticals today provides an update on the clinical development of IMO-2055 (EMD 1201081), a TLR9 agonist for cancer treatment being developed by Merck KGaA, Darmstadt, Germany, under its collaboration with Idera.

8 Jul 2011

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Identifying a suitable donor for leukemia and lymphoma patients who need bone marrow transplants may be far easier now that results of two clinical trials show transplant results with half-matched bone marrow or umbilical cord blood are comparable to fully matched tissue, thanks in large part to the availability of effective antirejection drugs and special post-transplant chemotherapy.

8 Jul 2011

Autologous adult stem cells reduce frequency of angina episodes

New research published online today in Circulation Research found that injections of adult patients' own CD34+ stem cells reduced reports of angina episodes and improved exercise tolerance time in patients with chronic, severe refractory angina (severe chest discomfort that did not respond to other therapeutic options).

From Baxter International Inc. 8 Jul 2011

Novartis Afinitor Phase III trial on tuberous sclerosis meets primary endpoint

Novartis Pharmaceuticals Corporation announced today Phase III trial results that showed more than one-third of patients taking Afinitor tablets experienced a 50% or greater reduction in the size of their subependymal giant cell astrocytomas, non-cancerous brain tumors associated with tuberous sclerosis complex.

8 Jul 2011

InVivo files biopolymer scaffold IDE with FDA to initiate spinal cord injury clinical trial

InVivo Therapeutics today announced that the Company has submitted an Investigational Device Exemption (IDE) to the U.S. Food and Drug Administration (FDA) for a proprietary biopolymer scaffolding device to protect and support spinal tissue and prevent secondary injury, including inflammation and glial scarring, following traumatic spinal cord injury.

8 Jul 2011

Exenatide tQT clinical trial meets pre-specified primary endpoint

Amylin Pharmaceuticals, Inc., Eli Lilly and Company and Alkermes, Inc. today announced results from a thorough QT (tQT) study that assessed the potential of exenatide to increase the QT interval across a wide range of plasma concentrations.

8 Jul 2011

Half-matched transplants widen donor pool for leukemia and lymphoma

7 Jul 2011

Study: Cancer patients with VTE do not benefit from IVCF and fondaparinux

Cancer patients with blood clots -- which occur in one of every 200 cancer patients and are the second most common cause of death among cancer patients -- gain no benefit from the insertion of an inferior vena cava filter (IVCF) to the anticoagulant medication fondaparinux (Arixtra), according to research presented today at the 14th World Conference on Lung Cancer, hosted by the International Association for the Study of Lung Cancer.

7 Jul 2011

Endoscopic testing prior to lung cancer surgery improves quality of life

Patients who underwent endoscopic testing prior to surgery for lung cancer had significantly better quality of life at the end of the staging process, with no significant difference in costs between the two strategies, according to data presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer.

7 Jul 2011

Bariatric surgery patients can benefit from rigorous exercise program

Bariatric surgery patients can undertake a rigorous exercise program after the procedure, in order to continue to lose weight and avoid regaining weight, according to a UT Southwestern Medical Center study.

7 Jul 2011

First transcatheter aortic valve implantation performed at Loyola University Hospital

Toni Meyer's heart-valve disease was so severe that she suffered shortness of breath even while sitting in a chair. But after Loyola University Hospital physicians replaced her diseased aortic valve in a catheter procedure as part of a clinical trial, Meyer said she is feeling "100 percent better."

From Medtronic 7 Jul 2011

Cumulus cells can provide information about genetic and chromosomal status of eggs

At present, when a woman undergoes preimplantation genetic screening (PGS) in a fertility clinic, doctors are trying to select an egg or an embryo that is healthy and doesn't have a chromosome abnormality such as an extra copy of chromosome 21, which causes Down's syndrome. In order to establish this, they either have to biopsy a part of the egg called the polar body or remove a cell from the embryo for screening. Both procedures are expensive, invasive and can damage the egg or embryo.

6 Jul 2011

New insight into tumor biology

Cancer cells are well known for their altered metabolisms, which may help them generate the energy they need for rapid growth. Using an emerging imaging technology, researchers reporting in the July Cell Metabolism, a Cell Press publication, have discovered that those metabolic shifts actually develop even before detectable tumors form.

6 Jul 2011

High folate intake linked with reduced risk of colorectal cancer

A new study finds high folate intake is associated with a reduced risk of colorectal cancer, a finding consistent with the findings of most previous epidemiologic studies.

6 Jul 2011

Antimicrobial copper surfaces reduce risk of acquiring hospital infection

Professor Bill Keevil, Head of the Microbiology Group and Director of the Environmental Healthcare Unit at the University of Southampton, has presented research into the mechanism by which copper exerts its antimicrobial effect on antibiotic-resistant organisms at the World Health Organization's first International Conference on Prevention and Infection Control.

2 Jul 2011

Scientists to test whether fish oil can prevent metastatic bowel cancer

Researchers from the University of Leeds will carry out a series of experiments to see whether fish oil can prevent or treat the spread of bowel cancer to the liver.

2 Jul 2011

Low-dose spiral CT scan can decrease mortality from lung cancer

Current or heavy smokers who were screened with low-dose spiral computed tomography (CT) scanning had a 20 percent reduction in deaths from lung cancer than did those who were screened by chest X-ray, according to results from a decade-long, large clinical trial that involved more than 53,000 people.

1 Jul 2011

Pill for rare ageing disease on the horizon

Scientists have found that a drug used in transplant patients could reverse the effects of premature ageing and extend human life by over 10 years.

1 Jul 2011

Clinical Trial News and Research

Preliminary results from Generex Oral-lyn clinical trial on type 1 diabetes

EU countries should pool funding to create 'prize' for bringing new antibiotics to market, report says

Merck decides not to advance IMO-2055 development for squamous cell carcinoma of the head and neck

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Autologous adult stem cells reduce frequency of angina episodes

Novartis Afinitor Phase III trial on tuberous sclerosis meets primary endpoint

InVivo files biopolymer scaffold IDE with FDA to initiate spinal cord injury clinical trial

Exenatide tQT clinical trial meets pre-specified primary endpoint

Half-matched transplants widen donor pool for leukemia and lymphoma

Study: Cancer patients with VTE do not benefit from IVCF and fondaparinux

Endoscopic testing prior to lung cancer surgery improves quality of life

Bariatric surgery patients can benefit from rigorous exercise program

First transcatheter aortic valve implantation performed at Loyola University Hospital

Cumulus cells can provide information about genetic and chromosomal status of eggs

New insight into tumor biology

High folate intake linked with reduced risk of colorectal cancer

Antimicrobial copper surfaces reduce risk of acquiring hospital infection

Scientists to test whether fish oil can prevent metastatic bowel cancer

Low-dose spiral CT scan can decrease mortality from lung cancer

Pill for rare ageing disease on the horizon

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