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New research gives unprecedented view of colorectal cancer genetic makeup

Researchers provided a comprehensive genomic characterization of colorectal carcinoma, a type of cancer that starts in the colon or rectum, through whole-genome sequencing of 2,023 samples, identifying novel driver genes, molecular subgroups, and potential clinical implications.

15 Aug 2024

Study reveals a paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia

Researchers at Children's Hospital of Philadelphia (CHOP), St. Jude Children's Research Hospital (St. Jude) and the Children's Oncology Group (COG) today announced a significant paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia (T-ALL), an aggressive and high-risk form of cancer, to one frequently driven by genetic changes in non-coding portions of our DNA.

14 Aug 2024

Study reveals how chromatin structure influences social behavior in dogs

A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior.

14 Aug 2024

Are personality traits linked to psychiatric disorders? Genome-wide study reveals genetic connections

Researchers identified 208 significant loci for neuroticism, revealing complex genetic influences on personality traits and their links to psychiatric conditions like depression and anxiety.

13 Aug 2024

Largest multi-omics study identifies new genetic landscapes in colorectal cancer

The Institute of Intelligent Medical Research (IIMR) of BGI Genomics, in collaboration with Sweden's Uppsala University, has published the largest multi-omics study of colorectal cancer (CRC) to date.

13 Aug 2024

Study reveals sharp increase in emergency department visits due to water beads

Researchers from the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children's Hospital have found more than an estimated 8,000 visits to U.S. emergency departments (EDs) associated with water beads from 2007 through 2022, and the number of these visits increased rapidly by more than 130% from 2021 to 2022.

13 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

12 Aug 2024

New breast cell atlas sheds light on genetic ancestry's role in cancer development

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date.

12 Aug 2024

Researchers identify key genetic players in dopamine signaling using transparent worms With The Help Of A Tin...

Dopamine, a powerful brain chemical and neurotransmitter, is a key regulator of many important functions such as attention, experiencing pleasure and reward, and coordinating movement.

12 Aug 2024

Prenatal BPA exposure tied to autism risk in boys

Study reveals that prenatal exposure to BPA disrupts aromatase activity in male brains, potentially leading to autism-like symptoms. Treatment with 10-HDA shows promise in reversing these effects.

11 Aug 2024

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

9 Aug 2024

Breakthrough study uncovers TIP60’s role in DNA access and disease mechanisms

To transcribe the information contained in our genes or to repair the dozens of breaks that occur daily in our DNA, our enzymes must be able to directly access the DNA to perform their functions.

9 Aug 2024

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

Since the genetic code was first deciphered in the 1960s, our genes seemed like an open book. By reading and decoding our chromosomes as linear strings of letters, like sentences in a novel, we can identify the genes in our genome and learn why changes in a gene's code affect health.

9 Aug 2024

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells.

8 Aug 2024

Breakthrough study highlights ATM activation by DNA single-strand breaks

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

7 Aug 2024

KAUST researchers uncover LINE-1 RNA’s role in triggering bone repair

Around half of the human genome is composed of DNA fragments originating from ancient viruses. These "transposable elements" (TEs) are now known to play various roles in modulating gene expression and disease development.

7 Aug 2024

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA).

7 Aug 2024

Study advances understanding of complex neurological disorder

To effectively treat a disease or disorder, doctors must first know the root cause. Such is the case for developmental and epileptic encephalopathies (DEEs), whose root causes can be hugely complex and heterogeneous. Scientists at St. Jude Children's Research Hospital demonstrated the value of DNA methylation patterns for identifying the root cause of DEEs, showing specific gene methylation and genome-wide methylation "episignatures" can help identify the genes that cause DEE. The findings were published today in Nature Communications.

7 Aug 2024

Study reveals distinct genetic risk factors for influenza and COVID-19

A recent study in Nature Genetics reports that genetic risk factors for influenza and COVID-19 are distinct, highlighting their unique genetic architectures.

6 Aug 2024

Genome News and Research

New research gives unprecedented view of colorectal cancer genetic makeup

Study reveals a paradigm shift in the understanding of T-lineage acute lymphoblastic leukemia

Study reveals how chromatin structure influences social behavior in dogs

Are personality traits linked to psychiatric disorders? Genome-wide study reveals genetic connections

Largest multi-omics study identifies new genetic landscapes in colorectal cancer

Study reveals sharp increase in emergency department visits due to water beads

Researchers develop new method to study critical type of protein modification process

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

New breast cell atlas sheds light on genetic ancestry's role in cancer development

Researchers identify key genetic players in dopamine signaling using transparent worms With The Help Of A Tin...

Prenatal BPA exposure tied to autism risk in boys

DeepPBS: A geometric AI model for accurate prediction of protein-DNA binding specificity

Breakthrough study uncovers TIP60’s role in DNA access and disease mechanisms

Columbia study reveals bacteria create free-floating genes, challenging genetic code norms

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

Breakthrough study highlights ATM activation by DNA single-strand breaks

KAUST researchers uncover LINE-1 RNA’s role in triggering bone repair

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

Study advances understanding of complex neurological disorder

Study reveals distinct genetic risk factors for influenza and COVID-19

Genetics & Genomics - Second Edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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