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SARS-CoV-2 antibody models describe differences between the kinetics of different antibodies

Researchers have created kinetic models of IgG and IgM anti-SARS-CoV-2 antibodies over 13.5 months following infection to understand long-lasting immunity better.

20 Sep 2021

Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

Researchers from the University of Southern California investigated mutations in the N-terminal and RBD domains of the spike protein.

20 Sep 2021

First dose of COVID-19 mRNA vaccine (BNT162b2) reduced platelet polyP levels in young females

In a recent study, scientists have tested the hypothesis that indicates the role of polyP in the COVID-19 mRNA vaccine-induced immune responses.

20 Sep 2021

New discovery reveals how immune 'sentinel' cells are maintained

WEHI researchers have made a surprise discovery about how immune 'sentinel' cells are maintained, which could have implications for drugs in development for treating cancer.

20 Sep 2021

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

In a recent study released on the bioRxiv* preprint server, the researchers suggest that an aberrant inflammatory reaction associated with COVID-19 could be a result of escape from direct sensing by toll-like receptors (TLRs). Moreover, the researchers indicate that this phenomenon might underlie the lack of efficient immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early during infection.

20 Sep 2021

Study highlights the usefulness of organoids for basic research into coronaviruses

Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection.

20 Sep 2021

The influence of prior seasonal coronavirus infection on disease severity in COVID-19

A new study posted to the bioRxiv* server attempted to explore anti-spike IgG responses, Fc-gamma receptor (FcγR) activation, IgG targeting of immunodominant regions, and recall responses due to seasonal hCoV infections in non-hospitalized COVID-19 patients.

20 Sep 2021

Development of a potential pan-variant aerosol to manage COVID-19

Researchers hypothesized that if APN01 could be directly introduced into the airways of an infected person, it could locally neutralize SARS-CoV-2.

19 Sep 2021

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

A new study utilized MVA to develop vaccine candidates that were subsequently evaluated in animal models of congenital cytomegalovirus disease.

19 Sep 2021

New data shows benefit of drug combination for metastatic castration resistant prostate cancer

New findings by researchers at Yale Cancer Center show the drug combination of nivolumab and rucaparib shows clinical activity for patients with chemotherapy-naïve, metastatic castration resistant prostate cancer (mCRPC).

18 Sep 2021

Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

18 Sep 2021

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

Working with light to activate processes within genetically modified fission yeast cells is among the research performed by the experimental biologists in the Martin Lab at the University of Lausanne, led by faculty member Sophie Martin.

18 Sep 2021

R37 MERIT Award supports innovative ovarian cancer research

One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.

18 Sep 2021

Novel drug combinations improve progression-free survival for patients with advanced NSCLC

New findings from a large study led by researchers at Yale Cancer Center shows the addition of the drugs oleclumab or monalizumab to durvalumab improved progression-free survival for patients with locally advanced non-small cell lung cancer (NSCLC).

18 Sep 2021

Increased presence of certain bacteria in the gut may indicate colon cancer risk

A study published today in the journal Cell Host & Microbe reported that the increased presence of certain bacteria in a gut biome indicates a greater likelihood that colon polyps will become cancerous.

18 Sep 2021

Research reveals a possible new treatment approach for pediatric rhabdomyosarcoma

Scientists at St. Jude Children's Research Hospital have revealed how the tumor suppressor gene PTEN plays a more important role in pediatric rhabdomyosarcoma than was previously appreciated.

18 Sep 2021

AI can help with the diagnosis of B-cell lymphomas and related leukemias

The presence of cancer of the lymphatic system is often determined by analyzing samples from the blood or bone marrow.

18 Sep 2021

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

17 Sep 2021

Scientists discover new cell type in human skin that contributes to inflammatory skin diseases

A team of international scientists and clinical experts have unraveled a new cell type in human skin that contributes to inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PSO). Their study findings were published in the Journal of Experimental Medicine in September 2021.

17 Sep 2021

Scientists examine kids’ unique immune systems as more fall victim to covid

Eighteen months into the covid-19 pandemic, with the delta variant fueling a massive resurgence of disease, many hospitals are hitting a heartbreaking new low. They're now losing babies to the coronavirus.

17 Sep 2021

B Cell News and Research

SARS-CoV-2 antibody models describe differences between the kinetics of different antibodies

Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

First dose of COVID-19 mRNA vaccine (BNT162b2) reduced platelet polyP levels in young females

New discovery reveals how immune 'sentinel' cells are maintained

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

Study highlights the usefulness of organoids for basic research into coronaviruses

The influence of prior seasonal coronavirus infection on disease severity in COVID-19

Development of a potential pan-variant aerosol to manage COVID-19

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

New data shows benefit of drug combination for metastatic castration resistant prostate cancer

Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

Researchers discover new mechanism used by a simple yeast cell to acquire its shape

R37 MERIT Award supports innovative ovarian cancer research

Novel drug combinations improve progression-free survival for patients with advanced NSCLC

Increased presence of certain bacteria in the gut may indicate colon cancer risk

Research reveals a possible new treatment approach for pediatric rhabdomyosarcoma

AI can help with the diagnosis of B-cell lymphomas and related leukemias

Scientists identify new approach to overcome resistance to cancer immunotherapy

Scientists discover new cell type in human skin that contributes to inflammatory skin diseases

Scientists examine kids’ unique immune systems as more fall victim to covid

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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