Malignant News and Research

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Researchers develop diagnostic test to determine risk of developing malignant breast cancer

Currently, with a pre-malignant breast cancer diagnosis from a biopsy, there are three options: observation, chemoprevention or surgery, all of which require a patient to make decisions while operating from a place of fear and unknown outcomes.

31 Oct 2018

Study shows how machinery within immune system activates T cells to attack cancer

In just a few years, CAR T-cell and other adoptive T-cell therapies have emerged as among the most promising forms of cancer immunotherapy.

31 Oct 2018

Scientists pinpoint TIM-3 protein as next potential target for immunotherapy treatments

Following the 2018 Nobel Prize for Medicine, global attention is now more than ever turned toward the promise of immunotherapy in oncology. An international team’s work has shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune response.

31 Oct 2018

New ultrasound technique shows great promise in detecting breast cancer

A new ultrasound technique can help distinguish benign breast tumors from malignant ones. The technology was developed with support from the Swiss National Science Foundation.

30 Oct 2018

Insights into tumor initiation pave way for new skin cancer treatments

Researchers from VIB and KU Leuven uncovered a key vulnerability of melanoma. While studying the role of the melanoma-specific long non-coding RNA SAMMSON in tumor initiation, the researchers found that it boosts protein synthesis in different cellular compartments. Normal cells are alerted by modification in protein synthesis and react to this threat, but only if this process is altered in one compartment at the time.

29 Oct 2018

Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S announced study results on the safety and efficacy of brexpiprazole in the treatment of patients with schizophrenia experiencing severe psychotic symptoms during an acute episode. The data will be presented at the upcoming Psych Congress, held in Orlando from October 25-28, 2018.

26 Oct 2018

Samara scholars assessed a new way of skin cancer early diagnostics

A team of scholars of Samara National Research University and Samara State Medical University as well as clinic specialists of Samara Regional Oncology Centre tested a new way of skin cancer early diagnostics with the help of original complex of three devices.

25 Oct 2018

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

AbbVie, a research-based global biopharmaceutical company, today announced positive results from U-ACHIEVE, an ongoing Phase 2b/3 dose-ranging study evaluating upadacitinib, an investigational JAK1-selective inhibitor, for induction and maintenance therapy in adult patients with moderately to severely active ulcerative colitis.

23 Oct 2018

NCI grant awarded to Abramson Cancer Center to study CAR T cells In solid tumors

A new program project grant from the National Cancer Institute will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor T cell therapy at fighting solid tumors.

23 Oct 2018

$Phase III LONSURF study shows progression-free survival in patients with refractory metastatic gastric cancer$

Phase III LONSURF study shows progression-free survival in patients with refractory metastatic gastric cancer

Servier and Taiho Oncology, Inc. (U.S.), a subsidiary of Taiho Pharmaceutical Co., Ltd. (Japan), jointly announced today clinical data from the pivotal Phase III TAS-102 Gastric Study (TAGS) evaluating LONSURF® (trifluridine/tipiracil, TAS-102) versus placebo and best supportive care in patients with heavily pre-treated metastatic gastric cancer who have progressed or are intolerant to previous lines of therapy.

22 Oct 2018

Researchers identify basic relationships of cell cycle and cellular senescence in the placenta

Working with researchers from Stanford University and St. Anna Children's Cancer Research, researchers from Jürgen Pollheimer's laboratory at the Medical University of Vienna's Department of Obstetrics and Gynecology have now, for the first time, identified basic relationships of the cell cycle and cellular senescence in the human placenta.

15 Oct 2018

Study identifies molecular switch that controls fate of milk-producing breast cells

A research team, led by investigators from Georgetown Lombardi Comprehensive Cancer Center, details how a natural and dramatic process -- changes in mammary glands to accommodate breastfeeding -- uses a molecular process believed to contribute to survival of pre-malignant breast cells.

15 Oct 2018

Two major studies on canine cancers may provide clues on human cancers

Two studies into deadly cancers in dogs are now underway, offered through the newly formed Clinical Trials Office at Cummings Veterinary Medical Center at Tufts University. Dogs with spontaneous osteosarcoma, as well as dogs with mast cell tumors and solid tumors, may be eligible for enrollment.

12 Oct 2018

AI approach could identify nuanced imaging features specific for recalled-benign mammograms

An artificial intelligence approach based on deep learning convolutional neural network could identify nuanced mammographic imaging features specific for recalled but benign (false-positive) mammograms and distinguish such mammograms from those identified as malignant or negative.

11 Oct 2018

Study: Mastectomy does not completely eliminate need for future breast imaging

The proportion of breast cancer patients who are eligible for breast conservation therapy, yet opt for mastectomy, is increasing, for reasons that include the desire to eliminate future screening and/or biopsy of the remaining breast tissue.

9 Oct 2018

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Verastem, Inc., focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that the National Comprehensive Cancer Network added COPIKTRA (duvelisib) capsules to the Clinical Practice Guidelines in Oncology (NCCN Guidelines) for follicular lymphoma.

8 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Medrobotics markets its Flex Robotic System for gastroenterology applications in Europe

Medrobotics Corp. today announced the first sale in Europe of their Flex Robotic System for gastroenterology applications.

4 Oct 2018

New approach helps identify molecular alterations linked to prognosis, resistance of cancer

A new computational approach that allows the identification of molecular alterations associated with prognosis and resistance to therapy of different types of cancer was developed by the research group led by Nuno Barbosa Morais, Group Leader at Instituto de Medicina Molecular João Lobo Antunes, and now published open access in Nucleic Acids Research.

4 Oct 2018

Could 'natural adaptive therapies' be a better way to keep cancer under control?

While many cancer therapies initially can be very successful, tumors often return and spread when remaining cancer cells develop resistance to treatment.

3 Oct 2018

Malignant News and Research

Researchers develop diagnostic test to determine risk of developing malignant breast cancer

Study shows how machinery within immune system activates T cells to attack cancer

Scientists pinpoint TIM-3 protein as next potential target for immunotherapy treatments

New ultrasound technique shows great promise in detecting breast cancer

Insights into tumor initiation pave way for new skin cancer treatments

Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

Samara scholars assessed a new way of skin cancer early diagnostics

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

NCI grant awarded to Abramson Cancer Center to study CAR T cells In solid tumors

Phase III LONSURF study shows progression-free survival in patients with refractory metastatic gastric cancer

Researchers identify basic relationships of cell cycle and cellular senescence in the placenta

Study identifies molecular switch that controls fate of milk-producing breast cells

Two major studies on canine cancers may provide clues on human cancers

AI approach could identify nuanced imaging features specific for recalled-benign mammograms

Study: Mastectomy does not completely eliminate need for future breast imaging

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Medrobotics markets its Flex Robotic System for gastroenterology applications in Europe

New approach helps identify molecular alterations linked to prognosis, resistance of cancer

Could 'natural adaptive therapies' be a better way to keep cancer under control?

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