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Fingerprint-embedding framework can help find novel drug candidates

Researchers have developed a new computer framework that holds promise in the work to discover new drugs. Their framework uses an artificial intelligence method called convolutional neural network to provide global information about potential novel drug candidates.

30 Nov 2022

Fragment crystallizable receptor-effector functions as a key correlate for pan-sarbecovirus vaccine development

Researchers elucidated pan-sarbecovirus immune protection mechanisms by utilizing a Venezuelan equine encephalitis virus-vectored vaccine panel that covered bat strains to human strains.

30 Nov 2022

The effects of mechanical forces on musculoskeletal cells and tissues

In this interview, Dr. Marina Danalache, Lab leader at the Laboratory of Cell Biology, Department of Orthopedic Surgery, University of Tübingen talks to News-Medical Life Sciences about the ongoing research on the effects of mechanical forces on musculoskeletal cells and tissues, as well as how these forces mediate homeostasis and drive pathophysiological processes.

From Bruker BioAFM 30 Nov 2022

Unique scaffolding material shows significant promise in the treatment of spinal cord injury

Unique new material developed at University of Limerick in Ireland has shown significant promise in the treatment of spinal cord injury.

29 Nov 2022

Broccoli and sprouts improve gut microbiota and reduce inflammation in IBD

Recently, scientists reviewed the role of sulforaphane from cruciferous vegetables (e.g., broccoli) in preventing IBD by regulating inflammation and altering the gut microbiome.

29 Nov 2022

Gut microbial flavonoid catabolite reverses fatty liver disease in mice

Researchers report that a gut microbial catabolite could reduce the cardiometabolic disease burden in mice.

29 Nov 2022

Endogenous system may be responsible for delayed onset of diabetic retinopathy

About one third of patients with diabetes mellitus (DM) develop diabetic retinopathy (DR), a leading cause of blindness in working-age individuals. DR typically develops after many years of DM, and some patients do not develop DR for more than 50 years.

29 Nov 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Isolated monoclonal antibodies neutralize SARS-CoV-2 Delta and Omicron variants.

28 Nov 2022

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

In a new study, researchers developed two monkeypox (MPX) virus (MPXV) quadrivalent messenger ribonucleic acid (mRNA) vaccines, mRNA-A-lipid nanoparticle (LNP) and mRNA-B-LNP.

28 Nov 2022

Using human iPSC-derived cells to revolutionize the field of neurodegenerative disease

In this interview, we speak to Axol Bioscience about their human iPSC-derived cells and how they have the potential to revolutionize the field of neurodegenerative disease.

From Axol Bioscience Ltd 28 Nov 2022

Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

How micro(nano)plastics interact with human gut microbiota

In a recent study published in the Microbial Biotechnology journal, researchers explored the health effects of micro(nano)plastics and their degraded products on the gut microbiome.

27 Nov 2022

Single-cell transcriptome analysis provides insights into bat immunity

In a world first, scientists at Duke-NUS Medical School and colleagues in Singapore have sequenced the response to viral infection in colony-bred cave nectar bats (Eonycteris spelaea) at single-cell resolution.

24 Nov 2022

Severe COVID-19 associated with an imbalance in key immune system signaling pathway

Researchers at the University of São Paulo in Brazil have found that severe COVID-19 is associated with an imbalance in an important immune system signaling pathway.

23 Nov 2022

Over 440 SCI articles published! BGI’s cancer genetics and cell research fuels innovation

BGI has currently published over 440 SCI (Science Citation Index) papers in the field of cancer research, with a cumulative impact factor of over 4,000 points.

From BGI Genomics 23 Nov 2022

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Scientists at UF Scripps Biomedical Research have developed a potential medicine for a leading cause of ALS and dementia that works by eliminating disease-causing segments of RNA. The

22 Nov 2022

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Sitting atop the kidneys, the adrenal gland plays a pivotal role in maintaining a healthy body. Responding to signals from the brain, the gland secretes hormones that support critical functions like blood pressure, metabolism, and fertility.

21 Nov 2022

Chitin-immobilized nanobodies for SARS-CoV-2 detection

Researchers demonstrated a novel strategy to detect SARS-CoV-2 using chitin-immobilized nanobodies.

21 Nov 2022

CAR T-cell therapy in colorectal cancer

Researchers assessed the efficacy of CAR T-cells in the immunotherapy of colorectal cancer.

21 Nov 2022

in vivo News and Research

Fingerprint-embedding framework can help find novel drug candidates

Fragment crystallizable receptor-effector functions as a key correlate for pan-sarbecovirus vaccine development

The effects of mechanical forces on musculoskeletal cells and tissues

Unique scaffolding material shows significant promise in the treatment of spinal cord injury

Broccoli and sprouts improve gut microbiota and reduce inflammation in IBD

Gut microbial flavonoid catabolite reverses fatty liver disease in mice

Endogenous system may be responsible for delayed onset of diabetic retinopathy

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

Using human iPSC-derived cells to revolutionize the field of neurodegenerative disease

Flavonoids with potential to fight allergies and inflammation

How micro(nano)plastics interact with human gut microbiota

Single-cell transcriptome analysis provides insights into bat immunity

Severe COVID-19 associated with an imbalance in key immune system signaling pathway

Over 440 SCI articles published! BGI’s cancer genetics and cell research fuels innovation

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Chitin-immobilized nanobodies for SARS-CoV-2 detection

CAR T-cell therapy in colorectal cancer

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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