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Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

In order to treat patients with diabetes in the best possible way it is necessary to understand the disease mechanism. MODY type 3 (MODY3) is a monogenic hereditary form of diabetes, that is caused by a genetic defect in the HNF1A gene.

22 Dec 2022

Wearable skin patch could help clinicians diagnose tumors, organ malfunction and more

Novel skin patch capable of deep detection of hemoglobin and core temperature.

22 Dec 2022

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

A new study in mice has helped illuminate how the brain's primary motor cortex (M1) – a brain region most commonly associated with control of motor functions – helps suppress dimensions of neuropathic pain.

22 Dec 2022

Using the gut microbiome to understand and treat respiratory diseases

Researchers review the role of the gut microbiome in certain respiratory diseases.

22 Dec 2022

Machine learning used to generate a new holistic model for coronary artery disease

A recent study published in the Lancet journal investigated whether a quantitative in-silico score for coronary artery disease (ISCAD), based on a machine learning model, can be used as a clinical marker to detect coronary artery disease.

21 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

First cell-type specific multiomic study of the HIV brain

Researchers identify cell-type-specific differences in HIV integration sites in the brain.

19 Dec 2022

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Researchers from Paul Scherrer Institute PSI and ETH Zurich have discovered how proteins in the cell can form tiny liquid droplets that act as a smart molecular glue.

19 Dec 2022

Developing stem cell sheet for enhancement of angiogenesis which promotes cardiac repair

Myocardial infarction is an ischemic disease in which a coronary artery supplying blood to the heart muscle is stenotic or obstructed, resulting in cardiac tissue necrosis.

16 Dec 2022

Changing heart cell programming can reverse the lasting damage caused by heart attacks

Back in 1971, the Bee Gees asked, "How can you mend a broken heart?". Now, researchers from Japan reveal that they may just have found a way to repair cardiac damage in patients suffering from chronic heart attack and heart failure.

16 Dec 2022

New chemical compound shows promise to reverse effects of potentially deadly drugs

Drug overdoses in the United States have risen sharply in the last two decades. Nearly 92,000 people died from overdoses of illegal drugs and prescription opioids in 2020 - more than five times the number of deaths in the year 2000 - and synthetic opioids like fentanyl are one of the main culprits.

16 Dec 2022

mRNA vaccine methodologies: Production, value and spectrometer use

To be decided by the editor

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 16 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

Scientists have developed a set of siRNAs against SARS-CoV-2 using computational approaches.

14 Dec 2022

The therapeutic effects and safety of psychedelics

Psychedelics are reported to have rapid-onset and long-lasting therapeutic benefits after a single or few doses.

14 Dec 2022

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

Hand-held biosensor enables rapid and accurate detection of oral cancer

Oral cancer is the 13th most common type of cancer globally, and oral squamous cell carcinomas (OSCCs) account for more than 90% of oral cancers.

13 Dec 2022

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

9 Dec 2022

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Scientists at Dana-Farber Cancer Institute have developed a drug that potently neutralizes SARS-CoV-2, the COVID-19 coronavirus, and is equally effective against the Omicron variant and every other tested variant.

7 Dec 2022

in vivo News and Research

Researchers identify a new pathogenic mechanism for diabetes onset in MODY3

Wearable skin patch could help clinicians diagnose tumors, organ malfunction and more

Mice study sheds light on how the brain's primary motor cortex helps suppress neuropathic pain

Using the gut microbiome to understand and treat respiratory diseases

Machine learning used to generate a new holistic model for coronary artery disease

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

First cell-type specific multiomic study of the HIV brain

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Developing stem cell sheet for enhancement of angiogenesis which promotes cardiac repair

Changing heart cell programming can reverse the lasting damage caused by heart attacks

New chemical compound shows promise to reverse effects of potentially deadly drugs

mRNA vaccine methodologies: Production, value and spectrometer use

Research reveals that a viral toxin may contribute to the severity of COVID-19

Bioinformatics approach for the design of siRNAs against SARS-CoV-2

The therapeutic effects and safety of psychedelics

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Hand-held biosensor enables rapid and accurate detection of oral cancer

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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