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New strategy for editing and repairing genetic mutation associated with microduplications

Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway.

11 Apr 2019

Scientists solve mystery surrounding common genetic cause of ALS

St. Jude Children's Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis, or Lou Gehrig's disease.

11 Apr 2019

Researchers find presence of Aire gene in lymph nodes

The thymus is the organ in which T cells differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses.

11 Apr 2019

Genetics may play a role in developing cancer therapy-induced cardiomyopathy

Recent advances in the development of cancer therapies have increased long-term survival and prognosis.

10 Apr 2019

Researchers map genetic mutation behind incurable disease

Researchers at Karolinska Institutet have mapped the genetic mutation behind the incurable disease systemic mastocytosis.

10 Apr 2019

Why hay fever persists, despite low pollen counts

A team of researchers are investigating why despite low forecasts of pollen counts, on some days, there is a higher incidence of hay fever.

10 Apr 2019

Newly developed approach efficiently assesses carcinogenicity of chemicals

Researchers from Boston University Schools of Medicine and Public Health have developed and evaluated a fast, accurate and cost-effective approach to assessing the carcinogenicity of chemicals--that is, whether exposure to a chemical increases a person's long-term cancer risk.

10 Apr 2019

Scientists develop new CRISPR-based 'allelic drive'

New CRISPR-based gene drives and broader active genetics technologies are revolutionizing the way scientists engineer the transfer of specific traits from one generation to another.

10 Apr 2019

Eight-year study identifies potential new way to treat extreme childhood food allergy

An eight-year hunt for the cells that drive the extreme childhood food allergy eosinophilic esophagitis has identified a potential new way to treat the disease while also raising questions about a dietary supplement often taken to reduce bowel inflammation.

9 Apr 2019

Study suggests novel therapeutic strategy for ALS

In a study published online in Brain on April 1, researchers from Dr. XU Jin's lab at the Institute of Neuroscience of the Chinese Academy of Sciences and their collaborators revealed a new cellular mechanism for amyotrophic lateral sclerosis, suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS.

9 Apr 2019

Researchers discover mechanism to form influenza A virus

The influenza A virus is known to form new strains every year. These strains are the result of small variations occurring at the level of the genome, which cause the virus to become different and no longer recognized by the immune system.

9 Apr 2019

Study compares library preparation and sequencing platforms for single-cell RNA-sequencing

Researchers from University of Southern Denmark, Wellcome Sanger Institute and BGI, today published a study in the journal Genome Biology comparing the library preparation and sequencing platforms for single-cell RNA-sequencing.

9 Apr 2019

Study finds no major epigenetic differences between space astronaut and his earthbound twin brother

In a landmark study, a group of U.S. scientists from Johns Hopkins, Stanford University and other institutions has found no long-lasting, major differences between the epigenomes of astronaut Scott Kelly, who spent a year in space aboard the International Space Station, and his twin brother, Mark, who remained on Earth.

9 Apr 2019

TGen review associates a gene with hepatocellular carcinoma

Hepatocellular carcinoma is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide.

9 Apr 2019