Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Liver transplant and weight-loss surgery combination offers long-term benefits to obese patients

Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows.

3 Oct 2018

Phase 3 ECHELON-2 clinical trial evaluating ADCETRIS plus CHP meets primary endpoint

Seattle Genetics, Inc. and Takeda Pharmaceutical Company Limited announced today that the phase 3 ECHELON-2 clinical trial met its primary endpoint.

1 Oct 2018

ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma

Seattle Genetics, Inc. today announced that its collaborator, Takeda Pharmaceutical Company Limited, has received approval from the Japanese Ministry of Health, Labour and Welfare for ADCETRIS (brentuximab vedotin) in combination with doxorubicin, vinblastine and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma patients in Japan.

24 Sep 2018

CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma

Ipsen announced today that the Committee for Medicinal Products for Human Use, the scientific committee of the European Medicines Agency, provided a positive opinion for Cabometyx (cabozantinib) as a monotherapy for the treatment of hepatocellular carcinoma in adults who have been previously treated with sorafenib.

21 Sep 2018

Novel method achieves accurate and precise temperature estimation in fat-containing tissues

Magnetic resonance thermometry is the only imaging technique that noninvasively provides temperature distribution in vivo. The water proton resonance frequency shift -based method is the most popular choice for MR temperature monitoring in aqueous tissues.

20 Sep 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Caspase-2 enzyme inhibitor could provide effective way to stop aggressive fatty liver disease

Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis, a chronic and aggressive liver condition.

14 Sep 2018

New test to predict advanced fibrosis in people with NAFLD

A new test may soon be available to predict advanced fibrosis in people with non-alcoholic fatty liver disease.

12 Sep 2018

Survey: Psoriasis patients expect treatment to go beyond just clear skin and safety

Novartis, a leader in immuno-dermatology, announced today new data from a patient preference survey showing psoriasis patients want their treatment to go beyond just clear skin and safety.

12 Sep 2018

Blocking RNA-silencing protein in the liver prevents obesity and diabetes in mice

Obesity and its related ailments like type 2 diabetes and fatty liver disease pose a major global health burden, but researchers report in Nature Communications that blocking an RNA-silencing protein in the livers of mice keeps the animals from getting fat and diabetic conditions.

11 Sep 2018

Study: Health and longevity improves with increased fasting time

Increasing time between meals made male mice healthier overall and live longer compared to mice who ate more frequently, according to a new study published in the Sept. 6, 2018 issue of Cell Metabolism.

7 Sep 2018

Bile acids reduce desire for cocaine, finds study

Bile acids -- gut compounds that aid in the digestion of dietary fats -- reduce the desire for cocaine, according to a new study by researchers at Vanderbilt University Medical Center and the University of Alabama at Birmingham.

31 Aug 2018

Restricting food to 10-hour window can lead to better health

Scientists at the Salk Institute found that mice lacking the biological clocks thought to be necessary for a healthy metabolism could still be protected against obesity and metabolic diseases by having their daily access to food restricted to a 10-hour window.

31 Aug 2018

Novel approaches for personalized risk prognosis and individualized treatment of NAFLD

More and more adults - but also about 34 percent of obese children - suffer from non-alcoholic fatty liver disease. An unhealthy lifestyle with little physical activity and a diet high in fat, sugar and fructose and/or a genetic predisposition can be the underlying caus.

31 Aug 2018

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Arrowhead Pharmaceuticals Inc. today announced that it has completed dosing of a Phase 1 clinical study of ARO-AAT, the company's second generation subcutaneously administered RNA interference therapeutic being developed as a treatment for a rare genetic liver disease associated with alpha-1 antitrypsin deficiency.

31 Aug 2018

Shionogi launches Mulpleta in the U.S for safe, effective treatment of thrombocytopenia

Shionogi & Co., Ltd. announced today that Mulpleta (lusutrombopag), a once-daily, orally administered, small molecule thrombopoietin (TPO) receptor agonist for the treatment of thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo a procedure, is now available throughout the United States.

30 Aug 2018

Routine oral care to treat gum disease may improve cognitive function in cirrhosis patients

Routine oral care to treat gum disease may play a role in reducing inflammation and toxins in the blood and improving cognitive function in people with liver cirrhosis.

29 Aug 2018

Newly discovered target may prevent progression of liver injury to cancer

Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.

27 Aug 2018

Alcohol in any amount harmful finds study

A large study has shown that abstaining completely from alcohol is the best way to protect from the harm it may cause. There have been previous studies that have shown that around one drink a day for women and two for men could be beneficial for protection against heart disease. This new study debunks that idea.

23 Aug 2018

CHLA researchers highlight need to include overweight subjects in metabolic research

Children's Hospital Los Angeles investigators have demonstrated the need to include a growing constituency of obese and overweight children and adults in clinical research, with their study of a key marker for metabolism and body temperature control.

23 Aug 2018

Liver Disease News and Research

Further Reading

Liver transplant and weight-loss surgery combination offers long-term benefits to obese patients

Phase 3 ECHELON-2 clinical trial evaluating ADCETRIS plus CHP meets primary endpoint

ADCETRIS drug receives approval in Japan as frontline treatment option for Hodgkin lymphoma

CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma

Novel method achieves accurate and precise temperature estimation in fat-containing tissues

New studies examine links between fatty liver disease and mitochondrial dysfunction

Caspase-2 enzyme inhibitor could provide effective way to stop aggressive fatty liver disease

New test to predict advanced fibrosis in people with NAFLD

Survey: Psoriasis patients expect treatment to go beyond just clear skin and safety

Blocking RNA-silencing protein in the liver prevents obesity and diabetes in mice

Study: Health and longevity improves with increased fasting time

Bile acids reduce desire for cocaine, finds study

Restricting food to 10-hour window can lead to better health

Novel approaches for personalized risk prognosis and individualized treatment of NAFLD

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Shionogi launches Mulpleta in the U.S for safe, effective treatment of thrombocytopenia

Routine oral care to treat gum disease may improve cognitive function in cirrhosis patients

Newly discovered target may prevent progression of liver injury to cancer

Alcohol in any amount harmful finds study

CHLA researchers highlight need to include overweight subjects in metabolic research

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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