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Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

Research sheds light on how the cell selects suitable protein fragments for robust T-cell response

As task forces of the adaptive immune system, T lymphocytes are responsible for attacking and killing infected or cancerous cells.

30 Sep 2022

Many diverse nanopore research directions and applications beyond DNA sequencing

In a recent Nature Nanotechnology study, researchers describe diverse applications of nanopore-based technology beyond deoxyribonucleic acid (DNA) sequencing. More specifically, the current research focuses on the advancements of this technology within chemistry, biophysics, and nanoscience.

29 Sep 2022

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

Researchers discuss a robust method to identify mutations that improve the expression and stabilize the conformation of the SARS-CoV-2 spike protein.

29 Sep 2022

Cancer cells 'hijack' a process used by healthy cells to spread around the body, research finds

Cancer Research UK-funded scientists have discovered that cancer cells 'hijack' a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.

29 Sep 2022

Study reveals how pathogens exploit a key cellular process to intoxicate cells

What our work shows is how a complex in the center of the cell, the ER-Golgi interaction region, controls plasma membrane cholesterol, which is essential for many cellular functions, if not essential for multicellular life.

28 Sep 2022

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.

28 Sep 2022

Mycoplasma genitalium infection during pregnancy may cause preterm birth

A systematic review and meta-analysis on the impacts of Mycoplasma genitalium infection on adverse pregnancy outcomes has been published in the BMJ journal Sexually Transmitted Infections.

28 Sep 2022

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells.

27 Sep 2022

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia explored the molecular mechanisms of the pulmonary and cardiac complications caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using human stem-cell-derived cardiac and lung cells.

27 Sep 2022

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

Researchers presented the direct plasmid transfection method for SARS-CoV-2 virus-like particle production in insect cells and applied the VLPs to evaluate the efficacy of monoclonal antibodies and vaccinated donor sera.

26 Sep 2022

What are the effects of heavy metals on the risk of endometriosis in reproductive-age women?

The current study focuses on lead, arsenic, cadmium, and mercury, all of which have been linked to the disordered functioning of the human reproductive system.

26 Sep 2022

How smallpox and monkeypox viruses affect the nervous system

A recent study provides an overview of existing literature on the complications of infection with both smallpox and monkeypox virus.

25 Sep 2022

Generating a mutation in key molecules could offer new way to prevent and treat gonorrhea

Creating a mutation that inhibits how the bacterial pathogen Neisseria gonorrhoeae causes gonorrhea, a common sexually transmitted infection, could offer a new way to prevent and treat the disease, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

23 Sep 2022

New engineered peptides could prevent the superbug crisis

A recent study reports the development of a synthetic antibacterial peptide PLG0206.

22 Sep 2022

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

A team led by Scripps Research scientists has uncovered key details of an immune-cell process that frequently underlies excessive inflammation in the body.

22 Sep 2022

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

In a recent study published in the journal PNAS, researchers from Finland and the United States reported a novel heptad repeat 2 (HR2) peptide that inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) without any chemical modifications.

21 Sep 2022

Virology of the human monkeypox virus

A new review to be posted in the Virus Research journal aims to provide an overview of the recent advances reported concerning hMPXV virology.

21 Sep 2022

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer's disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study.

21 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

Membrane News and Research

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

Research sheds light on how the cell selects suitable protein fragments for robust T-cell response

Many diverse nanopore research directions and applications beyond DNA sequencing

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

Cancer cells 'hijack' a process used by healthy cells to spread around the body, research finds

Study reveals how pathogens exploit a key cellular process to intoxicate cells

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

Mycoplasma genitalium infection during pregnancy may cause preterm birth

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

A fast and powerful method for the production of SARS-CoV-2 virus-like particles in insect cells

What are the effects of heavy metals on the risk of endometriosis in reproductive-age women?

How smallpox and monkeypox viruses affect the nervous system

Generating a mutation in key molecules could offer new way to prevent and treat gonorrhea

New engineered peptides could prevent the superbug crisis

Scientists uncover key details of an immune-cell process that underlies excessive inflammation

All SARS-CoV-2 variants blocked by a simple peptide with nanomolar neutralizing efficacy

Virology of the human monkeypox virus

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

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