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MIT researchers identify link between MEF2 gene and cognitive resilience in older individuals

Many people develop Alzheimer's or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration.

3 Nov 2021

UT Southwestern study suggests potential way to prevent Alzheimer’s disease

A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer's disease.

29 Oct 2021

$9 million grant from ASAP initiative to help advance research on Parkinson’s disease treatments

Researchers around the world have tried many ways, and for many years, to generate neurons in the lab so they could study them better. Neurons-on-demand might also provide a therapeutic option for replacing neurons lost in neurodegenerative conditions, such as Parkinson's disease.

27 Oct 2021

Northwestern scientists receive awards totaling nearly $18 million for Parkinson's disease research

Northwestern University scientists have received two awards totaling nearly $18 million for Parkinson's disease research from The ASAP Collaborative Research Network, a program of the Aligning Science Across Parkinson's (ASAP) initiative being implemented through The Michael J. Fox Foundation.

27 Oct 2021

Scientists flip a new piece in the male infertility puzzle

Scientists at Cincinnati Children's appear to have flipped another piece in the underexplored puzzle of male infertility.

27 Oct 2021

New mouse model shows that it is never too late to treat Hutchinson-Gilford Progeria Syndrome

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III and the Spanish Cardiovascular Research Network (CIBERCV), led by Dr Vicente Andrés, have generated the HGPSrev experimental mouse model.

26 Oct 2021

Researchers receive $8.9 million grant to study the gut-brain connection in Parkinson’s disease

Dr. Michael Kaplitt, a professor of neurological surgery at Weill Cornell Medicine and a longtime leader in developing cutting-edge surgical therapies for movement disorders, leads a team that has been awarded a three-year, $8.9 million grant from the Aligning Science Across Parkinson's (ASAP) initiative.

26 Oct 2021

Regulating blood insulin levels in obese, diabetic patients may help reduce COVID-19 risk

Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes. But now, researchers from Japan have found that regulating blood insulin levels may even help lower the risk of getting COVID-19.

25 Oct 2021

Study provides a specific target to tackle breast cancer relapse

Molecular targets for therapies that could prevent breast cancer recurrence have been identified by a group of German, Norwegian and British scientists who analyzed tumour cells that proved resistant to the original treatment.

25 Oct 2021

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

A heart attack kills heart muscle cells, leading to a scar that weakens the heart, often leading to eventual heart failure. The lack of muscle repair is due to the very limited ability of mammalian heart muscle cells to proliferate, except for a brief period around birth.

25 Oct 2021

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Osteocalcin (OCN) is a multifunctional bone-derived hormone that modulates numerous physiological activities. OCN can cross the blood brain barrier (BBB) and thus play critical roles in neuronal and brain development.

25 Oct 2021

Specific amino acid supplementation could prevent the development of dementia

Dementia- a condition involving the extreme loss of cognitive function- is caused by a variety of disorders, including Alzheimer's disease.

22 Oct 2021

Study reveals key role of fat cells in cognitive decline and neurodegeneration

Findings published this week reveal new insights into the role of fat cells in cognitive decline and neurodegeneration, according to a study that involves the oxidant amplification loop led by Marshall University scientists.

22 Oct 2021

Researchers identify a potential pathogenic link between IBD and mental comorbidities

In response to gut inflammation, such as that caused by inflammatory bowel disease (IBD), the vascular barrier in the brain choroid plexus closes, locking down access to the brain, according to a new study.

22 Oct 2021

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Like DNA, RNA molecules contain information through unique combinations of four different nucleotides. However, through a molecular process called RNA editing, chemical changes can be made to adenosine nucleotides that convert them to a nucleotide called inosine by enzymes known as adenosine deaminases (ADARs).

21 Oct 2021

Discovery could lead to new treatments for axial spondyloarthritis

In a paper published today in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute, part of University Health Network in Toronto, have made a discovery that could lead to new treatments for axial spondyloarthritis (SpA), a painful and debilitating form of arthritis which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin.

20 Oct 2021

Infrared light therapy may potentially benefit people with dementia

Infrared light therapy might have the potential to help people living with dementia, according to researchers.

19 Oct 2021

Study identifies the role of a key cell receptor in efferocytosis after ischemic stroke

It's clear that taking out the trash is an essential process in maintaining a clean and tidy home. But did you know that your body has a similar process for waste removal in which damaged cells are "thrown out"? A research team in Japan has recently shed new light on the dynamics of this process—termed efferocytosis—following ischemic stroke.

18 Oct 2021

Novel combination therapy identified for the brain metastases of breast cancer

A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy.

18 Oct 2021

Research reveals new role of immune cells that protect the brain from disease and injury

University of Virginia School of Medicine researchers have revealed a vital but previously unknown role for immune cells that protect the brain from disease and injury: The cells, known as microglia, also help regulate blood flow and maintain the brain's critical blood vessels.

18 Oct 2021

Mouse Model News and Research

MIT researchers identify link between MEF2 gene and cognitive resilience in older individuals

UT Southwestern study suggests potential way to prevent Alzheimer’s disease

$9 million grant from ASAP initiative to help advance research on Parkinson’s disease treatments

Northwestern scientists receive awards totaling nearly $18 million for Parkinson's disease research

Scientists flip a new piece in the male infertility puzzle

New mouse model shows that it is never too late to treat Hutchinson-Gilford Progeria Syndrome

Researchers receive $8.9 million grant to study the gut-brain connection in Parkinson’s disease

Regulating blood insulin levels in obese, diabetic patients may help reduce COVID-19 risk

Study provides a specific target to tackle breast cancer relapse

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

Study discloses molecular mechanism of oligodendrocyte myelination by osteocalcin in the CNS

Specific amino acid supplementation could prevent the development of dementia

Study reveals key role of fat cells in cognitive decline and neurodegeneration

Researchers identify a potential pathogenic link between IBD and mental comorbidities

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Discovery could lead to new treatments for axial spondyloarthritis

Infrared light therapy may potentially benefit people with dementia

Study identifies the role of a key cell receptor in efferocytosis after ischemic stroke

Novel combination therapy identified for the brain metastases of breast cancer

Research reveals new role of immune cells that protect the brain from disease and injury

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