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Virus-specific cellular immunity may be essential for long-term protection against SARS-CoV-2

Researchers from China and the US recently synthesized select peptide pools of the structural and functional proteins of SARS-CoV-2, including spike (S), envelope (E), membrane (M), nucleocapsid (N), and protease (P) proteins as target antigens to assess COVID-19-specific immunity.

22 Feb 2021

Organ transplant patient dies after receiving Covid-infected lungs

Doctors say a woman in Michigan contracted covid-19 and died last fall two months after receiving a tainted double-lung transplant from a donor who turned out to harbor the virus that causes the disease — despite showing no signs of illness and initially testing negative.

22 Feb 2021

Polycomb complexes found to be essential for proper skin development

Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in Genes & Development on February 18.

18 Feb 2021

Researchers develop a better solution to treat short bowel syndrome

Short Bowel Syndrome (SBS) is a medical disorder caused by a lack of a fully functional small intestine.

17 Feb 2021

3D bioprinting paves way for functional adult-sized tissues and organs

Research into 3D bioprinting has grown rapidly in recent years as scientists seek to re-create the structure and function of complex biological systems from human tissues to entire organs.

16 Feb 2021

Scientists discover two unique subtypes of a prominent mutation in patients with AML

Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation.

16 Feb 2021

Akkure Genomics raises €1.2 million to accelerate roll-out of its next-generation clinical trials platform

Akkure Genomics, an Irish digital health scaleup which is developing a disruptive MedTech platform for the global clinical trials industry, has raised just over €1.2 million in a crowdfunding campaign from 318 investors.

13 Feb 2021

Ionic liquid formulation kills cancer cells, allows uniform distribution of chemotherapy to tumors

A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab.

11 Feb 2021

STING activation may be a new approach to reduce graft-versus-host disease

MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease (GVHD).

11 Feb 2021

Single strain of bacteria may reduce the severity of graft-versus-host disease

MUSC Hollings Cancer Center researchers found that a single strain of bacteria may be able to reduce the severity of graft-versus-host disease (GVHD), as reported online in February 2021 in JCI Insight.

11 Feb 2021

Pandemic-fueled alcohol abuse creates wave of hospitalizations for liver disease

As the pandemic sends thousands of recovering alcoholics into relapse, hospitals across the country have reported dramatic increases in alcohol-related admissions for critical diseases like alcoholic hepatitis and liver failure.

10 Feb 2021

Study reveals mechanism behind “Fecal Microbiota Transplantation”

Clostridioides difficile infection (rCDI) occurs in the gut and is caused by the Gram-positive, spore-forming anaerobic bacterium, C. difficile when its spores attach to fecal matter and are transferred from hand to mouth by health care workers.

10 Feb 2021

Gut fungi teach the immune system how to respond to their dangerous relatives

Common fungi, often present in the gut, teach the immune system how to respond to their more dangerous relatives, according to new research from scientists at Weill Cornell Medicine. Breakdowns in this process can leave people susceptible to deadly fungal infections.

7 Feb 2021

Fecal transplant overcomes resistance to immunotherapy in melanoma patients

Researchers at UPMC Hillman Cancer Center and the National Cancer Institute demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy - which has a failure rate of 40% for this type of cancer - into patients who do.

5 Feb 2021

Study shows how SARS-CoV-2 evades immune responses

In a recurring pattern of evolution, SARS-CoV-2 evades immune responses by selectively deleting small bits of its genetic sequence, according to new research from the University of Pittsburgh School of Medicine.

4 Feb 2021

In Austin, some try to address vaccine inequity, but a broad plan is elusive

Communities of color have been among the hardest hit during the pandemic. But advocates in Texas say those communities are likely to have a harder time getting the vaccine in the coming months, so they are urging local leaders to step in.

3 Feb 2021

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins."

2 Feb 2021

Immune dysregulation can affect the efficacy of CAR T therapy in some lymphoma patients

Chimeric antigen receptor T-cell therapy, or CAR T, has been a breakthrough in the treatment of blood cancers such as acute lymphoblastic leukemia and diffuse large B-cell lymphoma.

2 Feb 2021

Young, Black patients at higher risk of death in the first year after a heart transplant

Young, Black adults are more than twice as likely to die in the first year after a heart transplant when compared to same-age, non-Black heart transplant recipients, according to new research published today in Circulation: Heart Failure, an American Heart Association journal.

2 Feb 2021

Study explains why people of African descent are less likely to find bone marrow donors

A paper by a multidisciplinary team of scientists affiliated with various Brazilian institutions, including the University of São Paulo (USP) and the National Cancer Institute (INCA), shows that people of African descent are less likely to find a donor in the National Register of Voluntary Bone Marrow Donors (REDOME) than people with predominantly European ancestry.

1 Feb 2021

Transplant News and Research

Virus-specific cellular immunity may be essential for long-term protection against SARS-CoV-2

Organ transplant patient dies after receiving Covid-infected lungs

Polycomb complexes found to be essential for proper skin development

Researchers develop a better solution to treat short bowel syndrome

3D bioprinting paves way for functional adult-sized tissues and organs

Scientists discover two unique subtypes of a prominent mutation in patients with AML

Akkure Genomics raises €1.2 million to accelerate roll-out of its next-generation clinical trials platform

Ionic liquid formulation kills cancer cells, allows uniform distribution of chemotherapy to tumors

STING activation may be a new approach to reduce graft-versus-host disease

Single strain of bacteria may reduce the severity of graft-versus-host disease

Pandemic-fueled alcohol abuse creates wave of hospitalizations for liver disease

Study reveals mechanism behind “Fecal Microbiota Transplantation”

Gut fungi teach the immune system how to respond to their dangerous relatives

Fecal transplant overcomes resistance to immunotherapy in melanoma patients

Study shows how SARS-CoV-2 evades immune responses

In Austin, some try to address vaccine inequity, but a broad plan is elusive

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

Immune dysregulation can affect the efficacy of CAR T therapy in some lymphoma patients

Young, Black patients at higher risk of death in the first year after a heart transplant

Study explains why people of African descent are less likely to find bone marrow donors

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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