Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

UB endocrinologist receives Junior Faculty Award to study effects of low testosterone in young men with type 2 diabetes

An endocrinologist in the University at Buffalo's School of Medicine and Biomedical Sciences has received a three-year $400,000 Junior Faculty Award from the American Diabetes Society to study the effects of low testosterone levels in young men with type 2 diabetes.

30 Oct 2010

Dental health affects control of diabetes

Diabetes is a disease that affects every part of the body, and for people with unstable blood glucose levels there is a higher risk than normal for developing serious complications from poor oral hygiene. In a study by dLife, the world's largest diabetes community, and SoundView Research, Inc., 66 percent of active diabetes managers had not changed their oral care habits since being diagnosed and over half have not been advised by their dentist to take extra care to brush, floss, or rinse daily.

29 Oct 2010

Lifestyle intervention programs result in significant weight loss for overweight and severly obese adults

Lifestyle interventions, including physical activity and structured weight loss programs, can result in significant weight loss for overweight, obese and severely obese adults, according to two reports that were posted online October 9 by JAMA. The studies and accompanying editorials were made available early online to coincide with the presentation of these papers at the 28th Annual Scientific Meeting of the Obesity Society. The articles appear in the October 27 print issue of JAMA.

27 Oct 2010

Repros commences randomization in Androxal Phase II study in T2DM men with low testosterone

Repros Therapeutics Inc. today announced it has commenced randomization of subjects into its Phase II Androxal® study in the treatment of type 2 diabetes (T2DM) in men with low testosterone. Low testosterone and T2DM are co-morbid conditions in a significant number of men. The study is being conducted at nine sites across the US including both academic and private practices and will enroll up to 150 patients.

25 Oct 2010

Study finds metabolic syndrome may indicate breast cancer risk in post-menopausal women

Metabolic syndrome, associated with the sedentary lifestyle and energy dense diet of Western industrialized societies, may be an indicator of breast cancer risk in post-menopausal women, according to a new study to be released at the National Italian American Foundation event, "Let's Talk About It: A Spotlight on Women's Health" on October 22nd at the Washington Hilton in Washington, D.C.

25 Oct 2010

Eating whole grains and limiting refined grains reduce body fat

People who consume several servings of whole grains per day while limiting daily intake of refined grains appear to have less of a type of fat tissue thought to play a key role in triggering cardiovascular disease and type 2 diabetes, a new study suggests. Researchers at the Jean Mayer USDA Human Nutrition Researcher Center on Aging (USDA HNRCA) at Tufts University observed lower volumes of visceral adipose tissue (VAT) in people who chose to eat mostly whole grains instead of refined grains.

21 Oct 2010

Metabolon receives patent for biomarkers to determine PPAR-affecting drugs

Metabolon, Inc., leaders in global metabolomics, biomarker discovery and biochemical analysis, announced today the grant of US Patent 7,807,138 entitled "Biomarkers of Metabolic Responses to Hepatic Drugs". The USPTO awarded the patent to Metabolon on October 5, 2010. This is the 13th patent issued to Metabolon and the second in its portfolio of biomarker patents.

21 Oct 2010

Study finds adipose dysfunction linked to steatosis, necroinflammation in G1 CHC patients

Researchers at the University of Palermo in Italy provide the evidence that a higher visceral adiposity index score-a new index of adipose dysfunction-has a direct correlation with viral load and is independently associated with both steatosis and necroinflammatory activity in patients with genotype 1 chronic hepatitis C (G1 CHC).

20 Oct 2010

An overview on American College of Gastroenterology's Annual Scientific meeting

The association between obesity and gastrointestinal-related cancers and coronary artery disease; the link between an overweight or obese body mass index and the severity of Crohn's disease; and whether inflammatory bowel disease is an independent risk factor for coronary artery disease, were among the highlights of new research that was presented this week at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio.

19 Oct 2010

MPI of Biochemistry and GSK collaborate in development of new drugs for type 2 diabetes

The recently signed cooperation agreement between the MPI of Biochemistry and GSK pursues the objective of developing innovative new drugs. The joint research and development work is based on the research findings of Axel Ullrich, Director at the MPI of Biochemistry.

19 Oct 2010

Study investigates effectiveness of potential treatment for Non-alcoholic steatohepatitis

Estimates of the prevalence of liver disease suggest that one‐third of the United States population has non‐alcoholic fatty liver disease (NAFLD). NAFLD is now the most common cause for elevated liver function tests in the United States, a trend related to the obesity epidemic in this country. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, can lead to cirrhosis and all its complications.

19 Oct 2010

Research team creates first 'lipidome' of human plasma

Human blood is famously fraught with fats; now researchers have a specific idea of just how numerous and diverse these lipids actually are. A national research team, led by scientists at the University of California, San Diego School of Medicine, has created the first "lipidome" of human plasma, identifying and quantifying almost 600 distinct fat species circulating in human blood.

15 Oct 2010

Study reveals copy number variants exclusive to obese children

A new study by pediatric researchers has added to the evidence that genes have a strong influence on childhood obesity.

15 Oct 2010

Metabolic screening before conception predicts development of diabetes in subsequent pregnancy

Cardio-metabolic risk factors such as high blood sugar and insulin, and low high density lipoprotein cholesterol that are present before pregnancy, predict whether a woman will develop diabetes during a future pregnancy, according to a Kaiser Permanente study in the current issue of the American Journal of Epidemiology.

13 Oct 2010

Insulin resistance increases risk of stroke in non-diabetic patients

Insulin resistance, a condition in which insulin produced by the body becomes less effective in reducing blood glucose levels, appears to be associated with an increased risk of stroke in individuals without diabetes, according to a report in the October issue of Archives of Neurology, one of the JAMA/Archives journals.

12 Oct 2010

Research reveals new details about health benefits of fish-oil

Some of America's most popular fish salmon and albacore tuna, for example are rich in healthful natural compounds known as omega-3 fatty acids. Ongoing studies by U.S. Department of Agriculture (USDA) chemist Darshan S. Kelley and co-investigators are helping uncover new details about how these fish-oil components help protect us from chronic diseases.

12 Oct 2010

Study to uncover genetic basis of obesity

An international consortium has made significant inroads into uncovering the genetic basis of obesity by identifying 18 new gene sites associated with overall obesity and 13 that affect fat distribution. The studies include data from nearly a quarter of a million participants, the largest genetic investigation of human traits to date.

11 Oct 2010

Lifestyle interventions benefit overweight, obese and severely obese adults

Lifestyle interventions, including physical activity and structured weight loss programs, can result in significant weight loss for overweight, obese and severely obese adults, according to two reports that were posted online today by JAMA. The studies and accompanying editorials were made available early online to coincide with the presentation of these papers at the 28th Annual Scientific Meeting of the Obesity Society. The articles will appear in the October 27 print issue of JAMA.

11 Oct 2010

Endocrine Society urges physicians to apply new insights into the role of beta-cells in type 2 diabetes

A new consensus statement published in the September, 2010, issue of The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) finds that the increasing recognition that beta-cell failure occurs much earlier and severely than commonly believed suggests that regular glycemia screening, early identification of patients at metabolic risk and prompt and aggressive intervention deserves greater emphasis.

7 Oct 2010

Insulin-sensitizing drugs may offer new treatments for kidney failure

Evidence reported in the October issue of Cell Metabolism, a Cell Press publication, offers a completely new explanation for why people with diabetes account for more than half of all patients requiring dialysis or kidney transplantation. It appears that insulin has a significant influence on the structure and proper function of a particular group of very specialized cells, known as podocytes, that are integral to the kidney's ability to do its job filtering blood.

6 Oct 2010

Insulin Resistance News and Research

Further Reading

UB endocrinologist receives Junior Faculty Award to study effects of low testosterone in young men with type 2 diabetes

Dental health affects control of diabetes

Lifestyle intervention programs result in significant weight loss for overweight and severly obese adults

Repros commences randomization in Androxal Phase II study in T2DM men with low testosterone

Study finds metabolic syndrome may indicate breast cancer risk in post-menopausal women

Eating whole grains and limiting refined grains reduce body fat

Metabolon receives patent for biomarkers to determine PPAR-affecting drugs

Study finds adipose dysfunction linked to steatosis, necroinflammation in G1 CHC patients

An overview on American College of Gastroenterology's Annual Scientific meeting

MPI of Biochemistry and GSK collaborate in development of new drugs for type 2 diabetes

Study investigates effectiveness of potential treatment for Non-alcoholic steatohepatitis

Research team creates first 'lipidome' of human plasma

Study reveals copy number variants exclusive to obese children

Metabolic screening before conception predicts development of diabetes in subsequent pregnancy

Insulin resistance increases risk of stroke in non-diabetic patients

Research reveals new details about health benefits of fish-oil

Study to uncover genetic basis of obesity

Lifestyle interventions benefit overweight, obese and severely obese adults

Endocrine Society urges physicians to apply new insights into the role of beta-cells in type 2 diabetes

Insulin-sensitizing drugs may offer new treatments for kidney failure

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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