Malignant News and Research

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Using clinical quality registers to compare institutions or physicians may be misleading

Many clinical quality registries have been established during the 2000s, particularly in North America where such registers are used as a criterion for health care funding.

28 Aug 2018

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Adding another inhibitor to therapies that cut off a tumor's access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.

27 Aug 2018

Researchers develop new system for effective cancer diagnosis and treatment

A research group consisting of scientists from NUST MISIS, the Technical University of Munich, Helmholtz Zentrum München, the University of Duisburg-Essen, and the University of Oldenburg has developed a system that allows doctors to both improve the accuracy of diagnosing malignant cells and to provide additional opportunities for cancer treatment.

24 Aug 2018

Researchers find new therapy to prevent drug resistance for melanoma patients

Mount Sinai researchers have discovered a previously unknown reason for drug resistance in a common subtype of melanoma, one of the deadliest forms of cancer, and in turn, have found a new therapy that could prevent or reverse drug resistance for melanoma patients with a particular gene mutation, according to a study published in Nature Communications in August.

24 Aug 2018

Advanced microscopes determine structure of molecular complex implicated in several cancers

In a study published today in Science, UT Southwestern and Rockefeller University researchers used advanced microscopes to determine at atomic resolution the structure of a molecular complex implicated in birth defects and several cancers.

24 Aug 2018

I-antigen plays major role in glycan-mediated processes, shows study

Two new studies have unveiled how a peculiar molecule impacts how antibody-producing cells develop and function as well as how normal melanocytes progress to melanoma malignancy.

23 Aug 2018

Pediatric brain tumor patients who undergo radiation less likely to recall recently experienced events

Children with certain types of brain tumors who undergo radiation treatment are less likely to recall the specifics of events they experienced after radiation than to remember pre-treatment happenings, according to a Baylor University study comparing them to children with healthy brains.

21 Aug 2018

Research explores relationship between personal history of infectious fever and cancer risk

Recurring patterns in patient accounts suggest the existence of an inverse relationship between personal history of infectious fever and cancer risk, and these patterns are documented throughout decades of medical literature.

17 Aug 2018

Innovative platform developed to destroy cancer cells

The new treatment will serve as both diagnosis and treatment of malignant tumors. This breakthrough in the technologies of cancer diagnosis and treatment was made by an interdisciplinary Russian-German collaboration of chemists, physicists, and biologists from NUST MISIS, Lomonosov Moscow State University, Pirogov Russian National Research Medical University (RNRMU), and the University of Duisburg-Essen (Germany).

17 Aug 2018

Cruciferous vegetables found to protect against colon cancer in mice

Researchers have revealed how vegetables such as broccoli, cabbage and kale help to maintain a healthy gut and protect against colon cancer.

15 Aug 2018

Scientists explore ways for drug therapies to reach deadly brain tumors

The blood-brain barrier is a specialized network of vascular and brain cells that acts as the brain's security system, helping to safeguard the brain and regulate the flow of substances into and out of it.

15 Aug 2018

Scientists identify stress hormone as key factor in failure of immune system to inhibit leukemia

The human stress hormone cortisol has been identified by scientists at the University of Kent as a key factor when the immune system fails to prevent leukemia taking hold.

14 Aug 2018

Scientists unravel the mystery behind ovarian cancer with high-grade serous carcinoma

More than two-thirds of women with ovarian cancer have high-grade serous carcinoma. Up to 90 percent of HGSCs are not detected until they are beyond the ovaries or fallopian tubes, at which point it may not be possible to fully remove the tumor.

14 Aug 2018

Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells

More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the "magic bullet" concept -- a method that clinicians might one day use to target invading microbes without harming other parts of the body. Although chemotherapies have been highly useful as targeted treatments for cancer, unwanted side effects still plague patients.

14 Aug 2018

Patients with chronic lymphocytic leukemia have higher risk of melanoma, shows study

While studying a large group of individuals with chronic lymphocytic leukemia, a Wilmot Cancer Institute scientific team made an important discovery -- these patients had a sizable 600 percent higher risk of melanoma, the most dangerous form of skin cancer.

10 Aug 2018

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

In the first such clinical trial in the United States, physician-scientists with the University of Maryland School of Medicine are investigating the use of MRI-guided focused ultrasound to open the blood-brain barrier.

10 Aug 2018

Scientists uncover reason for similarity between cells in malignant cancers and embryonic cells

Using just a microscope, Italian surgeon Francesco Durante was struck by the similarities between cells in the most malignant cancers and the embryonic cells of the organ in which the cancer originated.

9 Aug 2018

New CAR T-cell immunotherapy trial targets solid tumors

Seattle Children's has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

7 Aug 2018

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

AstraZeneca and Merck, known as MSD outside the U.S. and Canada, today announced that the European Medicines Agency (EMA) has granted orphan designation to selumetinib, a MEK 1/2 inhibitor, for the treatment of neurofibromatosis type 1 (NF1).

3 Aug 2018

Mushrooms from the Far East area could be used to design novel anti-cancer drugs

Mushrooms from the Far East area contain the natural chemical compounds, which could be used for the design of the novel drugs with highly specific anti-tumor activities and low-toxicity.

2 Aug 2018

Malignant News and Research

Using clinical quality registers to compare institutions or physicians may be misleading

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Researchers develop new system for effective cancer diagnosis and treatment

Researchers find new therapy to prevent drug resistance for melanoma patients

Advanced microscopes determine structure of molecular complex implicated in several cancers

I-antigen plays major role in glycan-mediated processes, shows study

Pediatric brain tumor patients who undergo radiation less likely to recall recently experienced events

Research explores relationship between personal history of infectious fever and cancer risk

Innovative platform developed to destroy cancer cells

Cruciferous vegetables found to protect against colon cancer in mice

Scientists explore ways for drug therapies to reach deadly brain tumors

Scientists identify stress hormone as key factor in failure of immune system to inhibit leukemia

Scientists unravel the mystery behind ovarian cancer with high-grade serous carcinoma

Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells

Patients with chronic lymphocytic leukemia have higher risk of melanoma, shows study

Researchers study use of MRI-guided focused ultrasound to open blood-brain barrier

Scientists uncover reason for similarity between cells in malignant cancers and embryonic cells

New CAR T-cell immunotherapy trial targets solid tumors

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

Mushrooms from the Far East area could be used to design novel anti-cancer drugs

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