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CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Researchers develop a more accurate way to scan for tuberculosis using PET

A more accurate way to scan for tuberculosis (TB) has been developed by UK and US researchers, using positron emission tomography (PET).

27 Jun 2024

MPA-CF3: A marine-derived compound disrupting COPZ1 to combat EV-A71

This study is spearheaded by researcher Wu Zhong (National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing) and Prof. Yong Qin (West China School of Pharmacy, Sichuan University).

26 Jun 2024

Researchers uncover molecular signatures of blood-brain barrier dysfunction in Alzheimer's disease

The blood-brain barrier - a network of blood vessels and tissues that nurtures and protects the brain from harmful substances circulating in the blood - is disrupted in Alzheimer's disease.

26 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Enhancing adoptive T-cell therapy with nanowire innovation

Adoptive T-cell therapy has revolutionized medicine. A patient's T-cells - a type of white blood cell that is part of the body's immune system - are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells.

24 Jun 2024

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

A new study led by University of Cincinnati researchers sheds new light on the role of a signaling pathway in the brain to maintain health and prevent inflammation and cognitive deficits.

24 Jun 2024

Innovative SRPFM technique enables ultra-sensitive force measurement at nanoscale in fluids

Groundbreaking research has revealed a new way to measure incredibly minute forces at the nanoscale in water, pushing the boundaries of what scientists know about the microscopic world.

24 Jun 2024

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Liver transplants associated with alcohol-related disease are growing at a rapid pace, shifting research to address pathologies behind the ailments in light of a limited supply of organ donors.

21 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

As a neurodegenerative disease characterized by childhood onset dementia, Sanfilippo syndrome causes immense suffering in many ways, including pain, loss of speech, extreme agitation, and distress, gastrointestinal symptoms, and profound sleep disturbance.

21 Jun 2024

Molecule News and Research

CHARMs: A new hope for prion disease therapy

Researchers develop a more accurate way to scan for tuberculosis using PET

MPA-CF3: A marine-derived compound disrupting COPZ1 to combat EV-A71

Researchers uncover molecular signatures of blood-brain barrier dysfunction in Alzheimer's disease

New enzyme targets hold promise for cancer therapies

Enhancing adoptive T-cell therapy with nanowire innovation

Study sheds light on the role of signaling pathway in the brain to prevent neuroinflammation

Innovative SRPFM technique enables ultra-sensitive force measurement at nanoscale in fluids

UT Health San Antonio researcher wins NIH grant to investigate alcohol-associated liver disease

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

Study links lifetime cannabis use with substance use, mood disorders, celiac, and infectious diseases

Artificial variants of Withanolides act highly specifically against leukemia cells

Unveiling the role of SOS genes in E. coli survival during antibiotic treatment

Proteins in blood may help to predict Parkinson’s disease up to seven years before the onset of motor symptoms

Novel AI tool poised to reshape virtual screening in early stage drug discovery

Mathematical modeling reveals hemoglobin's role in silent hypoxemia of COVID-19

Interdisciplinary team reveals how Porphyromonas gingivalis interferes with chemotherapy-induced mitophagy

Safety-focused summary of GLP-1 receptor agonists in diabetes, obesity, and beyond

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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