Oncogene News and Research

RSS

An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Effect of mutations in cancer-driving genes across human cancers

Effect of mutations in cancer-driving genes across human cancers.

9 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

4 Aug 2023

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

A recent study elucidated the molecular mechanisms of drug-induced regulation of growth differentiation factor 15 (GDF15).

1 Aug 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Cutting-edge research at the Luxembourg Institute of Health reveals the ground-breaking therapeutic potential of the compound FL3 in inhibiting oncogene translation and rewiring cancer cell metabolism, opening up new therapeutic opportunities for leukemia patients.

24 Jul 2023

Aneuploidy could function as a therapeutic target for cancer

Cancer cells with extra chromosomes depend on those chromosomes for tumor growth, a new Yale study reveals, and eliminating them prevents the cells from forming tumors.

6 Jul 2023

Senescent cells unlock the secret to luscious hair growth

The study findings indicate a peculiar pathway of regulation of hair growth by hair stem cells that is mediated by dermal melanocytes in senescence.

25 Jun 2023

Using Src N-terminal regulatory element as potential oncotarget

A new research perspective was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "Targeting the Src N-terminal regulatory element in cancer."

9 Jun 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

Study finds socio-economic inequalities in access to novel therapies for many NSCLC patients

Novel anti-cancer therapies were not accessible to more than half of the patients in England who were diagnosed with non-small cell lung cancer, according to a new study published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer.

19 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Researchers discover key epigenetic alteration associated with clinical course of liver cancer

Researchers at the Josep Carreras Leukaemia Research Institute, led by Dr. Manel Esteller, have discovered a key epigenetic alteration that anticipates the clinical course of liver cancer.

16 May 2023

Biomarker signature test can predict tumor response to bladder cancer immunotherapy

In a discovery that could improve the survival of bladder cancer patients, Northwestern Medicine scientists have developed a biomarker signature test to predict which tumors will respond to immunotherapy.

27 Apr 2023

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

A new research paper was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation."

26 Apr 2023

TONSL gene could be a new target for breast cancer treatment

While trying to understand what initiates breast cells to become cancerous, researchers at the Vera Bradley Foundation Center for Breast Cancer Research at Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a new target for breast cancer treatment.

20 Apr 2023

Oncogene News and Research

Further Reading

Effect of mutations in cancer-driving genes across human cancers

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Identification of plasma proteins associated with ovarian cancer risk

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Aneuploidy could function as a therapeutic target for cancer

Senescent cells unlock the secret to luscious hair growth

Using Src N-terminal regulatory element as potential oncotarget

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

Study finds socio-economic inequalities in access to novel therapies for many NSCLC patients

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Mast cells play a crucial role in the development of chronic myeloid leukemia

Researchers discover key epigenetic alteration associated with clinical course of liver cancer

Biomarker signature test can predict tumor response to bladder cancer immunotherapy

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

TONSL gene could be a new target for breast cancer treatment

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics