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Study compares GLP-1 drug benefits and finds substantial variation in clinical effects

GLP-1 receptor agonists improve glycaemic control and provide renal, metabolic, and selective cardiovascular benefits in people with type 2 diabetes, based on an umbrella review of 17 meta-analyses. However, these agents consistently increase gastrointestinal adverse effects and show important distinctions between class-level outcomes and individual drug effects, particularly for semaglutide.

20 Nov 2025

Aged blood vessel cells play key role in the development of metabolic disorders

Investigators from the Center for Advanced Gerotherapeutics at Cedars-Sinai found that aged blood vessel cells play a key role in the development of metabolic disorders, including diabetes.

20 Nov 2025

Study uncovers promising therapeutic strategies against neuroendocrine prostate cancer

A new study has uncovered promising therapeutic strategies against one of the deadliest forms of prostate cancer.

20 Nov 2025

Waning immunity and falling vaccination rates fuel pertussis outbreaks

Rates of pertussis, also known as whooping cough, are surging in Texas, Florida, California, Oregon, and other states and localities across the country.

20 Nov 2025

Study compares the kidney, cardiovascular and mortality risks of three different GLP-1 RAs

Public interest in drugs known as glucagon-like peptide-1 receptor agonists, also called GLP-1 RAs, has surged in recent years, with popular types like semaglutide (sold under brand names like Ozempic and Wegovy) becoming known for their weight-loss effects.

20 Nov 2025

Focused ultrasound can be safely used in children being treated for brain cancer

Columbia University researchers are the first to show that focused ultrasound - a non-invasive technique that uses sound waves to enhance the delivery of drugs into the brain - can be safely used in children being treated for brain cancer.

19 Nov 2025

New prognostic tool can predict transplant needs in drug-induced liver injury patients

A newly developed tool, called the DILI-Inpt prognostic score, can predict patients with drug-induced liver injury who are unlikely to survive without a liver transplant.

19 Nov 2025

Cryo-EM reveals how proteins are protected during synthesis

Proteins are often called the building blocks of cells, but even those building blocks need to be built. One of the most important steps in the process of building proteins is glycosylation, when sugar molecules (glycans) are attached to the maturing protein.

19 Nov 2025

Cancer cells hijack cell death enzyme to regrow after treatment

The emergence of cancer drug resistance remains one of the most pressing problems in cancer care and there is a critical need to devise approaches to mitigate it.

19 Nov 2025

Global report highlights persistent violence against women

Violence against women remains one of the world's most persistent and under-addressed human rights crises, with very little progress in two decades, according to a landmark report released today by the World Health Organization (WHO) and UN partners.

19 Nov 2025

New NIH grants support research on how brain fluid movement drives glioblastoma spread

Jennifer Munson, a cancer researcher at Virginia Tech's Fralin Biomedical Research Institute at VTC, has been awarded two new National Institutes of Health grants to advance greater understanding and improved treatment of a deadly brain cancer.

19 Nov 2025

Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patients

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline such as memory loss and behavioral disturbances that severely impair quality of life. Despite decades of research, effective disease-modifying therapies remain elusive, underscoring the urgent need for novel neuroprotective strategies.

19 Nov 2025

Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies

An international research group directed by UMC Utrecht have developed and characterized two first-in-class antibodies that specifically block the high-affinity IgG receptor FcγRI.

19 Nov 2025

New clinical trial shows promise for shorter TB treatment

New clinical trial results presented by TB Alliance at the Union World Conference on Lung Health show that the novel antibiotic candidate sorfequiline (TBAJ-876), a next-generation diarylquinoline, has the potential to improve tuberculosis (TB) treatment when combined with pretomanid and linezolid in a treatment regimen known as "SPaL."

19 Nov 2025

Oral semaglutide delivers real-world drops in blood sugar and weight in diabetes trial

Oral semaglutide delivered meaningful reductions in HbA1c and body weight among GLP-1RA-naïve adults with type 2 diabetes in a Dutch real-world cohort. Lipid levels and blood pressure showed only small changes, reflecting modest cardiometabolic effects outside glucose and weight control.

18 Nov 2025

New antibody strategy shows promise for halting cyst growth in polycystic kidney disease

Polycystic kidney disease (PKD) is a debilitating hereditary condition in which fluid-filled sacs form and proliferate in the kidneys. Over time, the painful, growing cysts rob the organs of their function, often leading to dialysis in advanced cases.

18 Nov 2025

DeepTarget tool uncovers primary and secondary drug targets across cancer types

One person's side effect could be another person's treatment if we expand our perspective on small molecule drug targets, according to a new study published November 5, 2025, in npj Precision Oncology.

18 Nov 2025

Tirzepatide reveals a brain signal that predicts returning food preoccupation

Researchers implanted electrodes in the human nucleus accumbens to track brain activity during severe food preoccupation in an individual taking tirzepatide. They found that a delta–theta biomarker disappeared during symptom-free periods and re-emerged weeks before relapse, suggesting a possible neural marker of vulnerability to dysregulated eating.

18 Nov 2025

Alzheimer’s drugs improve key cognitive skills in children with autism and low IQ

The review synthesizes evidence on whether Alzheimer’s disease medications can improve neurocognitive outcomes in children and adolescents with autism and low IQ. Across 12 studies, preliminary findings show promising gains in language, executive function, learning and memory, and general cognitive ability, particularly in younger children.

18 Nov 2025

Novel therapy reduces tumor growth in models of triple-negative breast cancer

Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and difficult-to-treat forms of the disease.

18 Nov 2025

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Drugs News and Research

Study compares GLP-1 drug benefits and finds substantial variation in clinical effects

Aged blood vessel cells play key role in the development of metabolic disorders

Study uncovers promising therapeutic strategies against neuroendocrine prostate cancer

Waning immunity and falling vaccination rates fuel pertussis outbreaks

Study compares the kidney, cardiovascular and mortality risks of three different GLP-1 RAs

Focused ultrasound can be safely used in children being treated for brain cancer

New prognostic tool can predict transplant needs in drug-induced liver injury patients

Cryo-EM reveals how proteins are protected during synthesis

Cancer cells hijack cell death enzyme to regrow after treatment

Global report highlights persistent violence against women

New NIH grants support research on how brain fluid movement drives glioblastoma spread

Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patients

Breakthrough in FcγRI inhibition opens path to safer autoimmune therapies

New clinical trial shows promise for shorter TB treatment

Oral semaglutide delivers real-world drops in blood sugar and weight in diabetes trial

New antibody strategy shows promise for halting cyst growth in polycystic kidney disease

DeepTarget tool uncovers primary and secondary drug targets across cancer types

Tirzepatide reveals a brain signal that predicts returning food preoccupation

Alzheimer’s drugs improve key cognitive skills in children with autism and low IQ

Novel therapy reduces tumor growth in models of triple-negative breast cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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