Drugs News and Research

RSS

Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage

Chronic alcohol use accelerates Alzheimer’s disease (AD) progression by intensifying oxidative stress, neuroinflammation, and amyloid-tau pathology through shared molecular pathways. The review highlights emerging therapies, targeting TLR4, GSK-3β, and metabolic dysfunction, that may mitigate alcohol-induced neurodegeneration.

20 Oct 2025

Oral combination regimen improves survival in ER-positive HER-2-negative breast cancer

Patients with estrogen-receptor-positive HER-2-negative advanced breast cancer showed significantly improved progression-free survival when treated with an oral combination regimen that includes giredestrant, a novel, next-generation selective estrogen receptor degrader and full antagonist, compared to a standard combination approach.

18 Oct 2025

New antibody drug conjugates can transform early HER2-positive breast cancer treatment

In a landmark moment at the ESMO Congress 2025, pivotal studies have unveiled compelling evidence that a new class of anti-cancer agents-antibody-drug conjugates (ADCs)-can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer.

18 Oct 2025

New 3D human brain tissue platform integrates all major brain cell types into a single culture

A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture.

17 Oct 2025

Scientists discover why a powerful leukemia drug fails in most patients

Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients – and found a potential way to overcome that resistance.

17 Oct 2025

Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1

A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in Antiviral Research on July 25.

17 Oct 2025

Improving logical reasoning in large language models for medical use

Large language models (LLMs) can store and recall vast quantities of medical information, but their ability to process this information in rational ways remains variable.

17 Oct 2025

GLP-1 drugs like Ozempic may slow how quickly alcohol hits the bloodstream

Preliminary study shows GLP-1 receptor agonists alter alcohol response, suggesting potential for reducing cravings and intoxication in obese individuals.

17 Oct 2025

AI predicts cell responses to drugs and genetic changes

Controlling the state of a cell in a desired direction is one of the central challenges in life sciences, including drug development, cancer treatment, and regenerative medicine.

16 Oct 2025

New vaccine label offers real-time heat exposure detection

A color-changing label could help prevent millions of vaccine doses from going to waste, say scientists from the University of Surrey. The innovation, now being commercialized through a partnership with MM PACKAGING GmbH (MM) Group and leading materials specialists Advanced Material Development Ltd (AMD), provides a low-cost and reliable way to show whether vaccines have been exposed to damaging heat.

16 Oct 2025

Cancer hijacks embryonic gene editors to fuel growth

Cancer cells are known to reawaken embryonic genes to grow. A new study reveals the disease also hijacks the proteins, or "editors", that control how those genes are read.

16 Oct 2025

New insights into how bacteria can drive treatment resistance in oral and colorectal cancer

Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer.

16 Oct 2025

World's largest-ever clinical trial launched to test treatments for Parkinson's disease

The world's largest-ever clinical trial of treatments to slow or stop the progression of Parkinson's disease has launched, led by researchers at UCL and Newcastle University.

16 Oct 2025

New enzyme offers cleaner route to more stable diabetes and obesity drugs

Chemistry researchers at the University of Utah have uncovered an enzyme, dubbed PapB, that can "tie off" therapeutic peptides-protein-like drugs-into tight rings, a process known as macrocyclization.

16 Oct 2025

KFF Health News' 'What the Health?': Schrödinger’s government shutdown

Democrats and Republicans are both facing potential political consequences in their continuing standoff over federal government funding.

16 Oct 2025

Uncovering a molecular weakness in Ewing sarcoma for targeted therapy

A research team at the Seville Biomedical Institute (IBis) has identified a new molecular mechanism that explains the high sensitivity of Ewing sarcoma (an aggressive bone cancer that mainly affects children and adolescents) to certain chemotherapy drugs, such as irinotecan.

16 Oct 2025

Fatty acids found to be a primary driver of triple-negative tumor growth

A team from Huntsman Cancer Institute at the University of Utah (the U) has found that triple-negative breast cancer is fueled by lipids and that these fatty acids are a key feature of obesity that promote tumor growth.

16 Oct 2025

FDA shares safety guidance for people considering microneedling

Being pricked by tiny needles may sound like a strange way to make your skin look better, but that's the concept behind a skin care technique called microneedling.

16 Oct 2025

Montreal chemists develop fast DNA-based sensor for drug monitoring

Chemists at Université de Montréal have developed "signaling cascades" made with DNA molecules to report and quantify the concentration of various molecules in a drop of blood, all within 5 minutes.

16 Oct 2025

Caraway seeds inspire new seizure-fighting medicines

A UNLV-led team of researchers has co-opted a common kitchen spice to create a new class of cannabidiol (CBD)-like medicines that show powerful seizure-reducing effects - offering a safer, more affordable, and more effective treatment for childhood seizure disorders than existing frontline therapies.

15 Oct 2025