Electron Microscopy News and Research

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Protein unfolding key to understanding blood clot mechanics

Fibrin, the chief ingredient of blood clots, is a remarkably versatile polymer. On one hand, it forms a network of fibers -- a blood clot -- that stems the loss of blood at an injury site while remaining pliable and flexible. On the other hand, fibrin provides a scaffold for thrombi, clots that block blood vessels and cause tissue damage, leading to myocardial infarction, ischemic stroke, and other cardiovascular diseases. How does fibrin manage to be so strong and yet so extensible under the stresses of healing and blood flow?

6 Aug 2009

Research looks at enzyme that causes genetic diseases

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the prestigious scientific journal Structure, to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state).

5 Aug 2009

Heat shock proteins provide protection against cataracts

The human eye lens consists of a highly concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective function fails, the lens blurs and the patient develops cataracts. Two research groups at the Department of Chemistry of the Technische Universitaet Muenchen (TUM) have succeeded in explaining the molecular architecture of this kind of protective protein.

31 Jul 2009

Bones from stem cell technology

Scientists are closer to understanding how to grow replacement bones with stem cell technology, thanks to research published today in the journal Nature Materials.

26 Jul 2009

Airway cells are chemosensory

The same mechanism that helps you detect bad-tasting and potentially poisonous foods may also play a role in protecting your airway from harmful substances, according to a study by scientists at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

24 Jul 2009

Structure of the HIV protein shell revealed

New research by scientists at The Scripps Research Institute and other institutions provides a close-up look at the cone-shaped shell that is the hallmark of human immunodeficiency virus (HIV), revealing how it is held together - and possible ways to break it apart.

13 Jun 2009

Scientists determine key structural features of mimivirus

The mimivirus is the largest virus known to scientists, about half of a micrometre (0.0005 millimeter) in diameter.

30 Apr 2009

New understanding of 3D structure of bacterial secretion proteins

New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection.

26 Apr 2009

Researchers show how PCBs may alter in utero, neonatal brain development

In three new studies - including one appearing online in the Public Library of Science - Biology (PLoS - Biology) - UC Davis researchers provide compelling evidence of how low levels of polychlorinated biphenyls (PCBs) alter the way brain cells develop.

13 Apr 2009

New brain mapping capabilities come to desktops of scientists worldwide

Mapping the billions of connections in the brain is a grand challenge in neuroscience.

30 Mar 2009

Synthesizing Vernix caseosa

Even after nine months soaking in the womb, a newborn's skin is smooth - unlike an adult's in the bath.

17 Mar 2009

New imaging techniques let scientists see biomolecules more clearly

Scientists have always wanted to take a closer look at biological systems and materials. From the magnifying glass to the electron microscope, they have developed increasingly sophisticated imaging devices.

23 Feb 2009

Groundbreaking study reveals how enzymes in the cell cooperate to make fat

These enzymes are integrated into a single molecular complex known as fatty acid synthase. This complex is regarded as a potential target for developing new anti-obesity and anti-cancer drugs.

11 Feb 2009

Scientists create first crystal structure of an intermediate particle in virus assembly

The structure, described February 8 in an advance online publication of the journal Nature , provides fresh insights into the elegant dance that viral proteins perform to create the infectious structure that causes all manner of misery and disease, say researchers.

8 Feb 2009

New technique images whole cells in liquid with a scanning transmission electron microscope

Scientists have always wanted to take a closer look at biological systems and materials.

19 Jan 2009

Discovery of novel ways to halt the spread of antibiotic resistance

Scientists have identified the structure of a key component of the bacteria behind such diseases as whooping cough, peptic stomach ulcers and Legionnaires' disease.

9 Jan 2009

Discovery of 'on switch' for cell death signaling mechanism

Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell death).

5 Jan 2009

Researchers identify clockwork that drives a powerful virus nanomotor

Peering at structures only atoms across, researchers have identified the clockwork that drives a powerful virus nanomotor.

30 Dec 2008

Biologists spy close-up view of poliovirus linked to host cell receptor

Researchers from Purdue and Stony Brook universities have determined the precise atomic-scale structure of the poliovirus attached to key receptor molecules in human host cells and also have taken a vital snapshot of processes leading to infection.

8 Dec 2008

Scientists shed light on how DNA is unwound so that its code can be read

Researchers at The Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be "read" and used to direct the synthesis of proteins, which have many specific functions in the body.

24 Nov 2008