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Researchers use prime editing to correct cystic fibrosis in cultured human stem cells

Researchers from the group of Hans Clevers (Hubrecht Institute) corrected mutations that cause cystic fibrosis in cultured human stem cells.

9 Aug 2021

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

In collaboration with Northwestern Medicine investigators, an international multi-center study has identified genetic factors associated with SARS-CoV-2 infection and COVID-19 severity, according to findings published in Nature.

6 Aug 2021

Immune system signaling molecule promotes the production of energy-burning 'beige fat'

An immune signal promotes the production of energy-burning "beige fat," according to a new study publishing August 5th in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues.

5 Aug 2021

Study investigates the role of eIF4A3 protein in the growth of cancer cells

For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published today in Science Advances, researchers at Karolinska Institutet in Sweden have investigated the protein eIF4A3 and its role in the growth of cancer cells.

4 Aug 2021

Scientists identify new therapeutic target for several aggressive cancers

A protein in tumor cells could be targeted to treat some types of aggressive cancer including brain, blood, skin, and kidney, new research has shown.

4 Aug 2021

NSF awards $441,028 to address the workforce needs of regenerative medicine

Regenerative medicine is a cross-disciplinary field that aims to repair or replace abnormal organs by growing tissues in the laboratory or cells for therapy.

3 Aug 2021

New moms latched on to remote breastfeeding help. Will demand wane as pandemic fades?

Madison Cano knew she wanted to breastfeed her son, Theo. But breastfeeding was painful for her. The skin on her breasts was chafed and blistered last July when she returned home from the hospital. And Theo sometimes screamed during feedings.

3 Aug 2021

Finding potential microRNAs from humans and plants against SARS-CoV-2

A new study focuses on the identification of probable miRNA candidates from three medicinal plants.

1 Aug 2021

UT Southwestern discovers the Achilles’ heel in ovarian cancers and potential biomarkers

UT Southwestern faculty have discovered what appears to be an Achilles' heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.

30 Jul 2021

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

Researchers from the Institute of Process Engineering of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy.

26 Jul 2021

SARS-CoV-2 antibodies in breast milk: Study

A new study published on the medRxiv* preprint server explores the presence of immunoglobulin (Ig) antibodies IgA and IgG against SARS-CoV-2 in breast milk secreted by women with confirmed infection. The scientists also delineated the specific antigens targeted by the antibodies.

26 Jul 2021

Study lays out challenges of achieving equity in communication for diverse patients at hospital discharge

A new study by research, quality improvement and health equity experts at Massachusetts General Hospital in The American Journal of Managed Care lays out the challenges of achieving equity for diverse patients in communication at hospital discharge.

21 Jul 2021

A path to treat currently untreatable cases of cystic fibrosis is clearly achievable, study suggests

An experimental drug reported in Nature Communications suggests that a "path is clearly achievable" to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations.

19 Jul 2021

Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication

In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C., when the conversation shifted to what was then a worrying viral epidemic in China.

19 Jul 2021

Tissue-specific genetic interactions drive different types of cancer development

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium, the Technical University of Munich, and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in precursor cells of the pancreas or the bile duct leads to fundamental different outcomes.

19 Jul 2021

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

The investigational therapeutic ficlatuzumab in combination with chemotherapy showed signs of clinical efficacy in patients with relapsed/refractory acute myeloid leukemia.

16 Jul 2021

Brain signals translated into speech give paralyzed man back his words

Scientists at UC San Francisco have successfully developed a "speech neuroprosthesis" device that has enabled a man with severe paralysis to communicate in sentences, translating signals from his brain to text on a screen.

15 Jul 2021

COVID-19 researchers review 184 drug repurposing candidates

New research describes the use of integrative bioinformatics analyses of transcriptomic profiles for COVID-19 therapeutics.

15 Jul 2021

Antihypertension drug may benefit patients with neurofibromatosis type 2

New research led by investigators at Massachusetts General Hospital and Massachusetts Eye and Ear indicates that the blood pressure drug losartan may benefit patients with neurofibromatosis type 2 (NF2), a hereditary condition associated with vestibular schwannomas, or noncancerous tumors along the nerves in the brain that are involved with hearing and balance.

15 Jul 2021

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Uveal melanoma, or UM, is a rare and deadly cancer of the eye, and the mortality rate has remained unimproved for 40 years. Half of the melanomas spread to other organs of the body, causing death in less than a year, so new treatments to preserve vision and prevent death are an urgent need.

15 Jul 2021

Translation News and Research

Researchers use prime editing to correct cystic fibrosis in cultured human stem cells

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

Immune system signaling molecule promotes the production of energy-burning 'beige fat'

Study investigates the role of eIF4A3 protein in the growth of cancer cells

Scientists identify new therapeutic target for several aggressive cancers

NSF awards $441,028 to address the workforce needs of regenerative medicine

New moms latched on to remote breastfeeding help. Will demand wane as pandemic fades?

Finding potential microRNAs from humans and plants against SARS-CoV-2

UT Southwestern discovers the Achilles’ heel in ovarian cancers and potential biomarkers

Researchers develop new exosome formulation to deliver VEGF antibodies for synergistic therapy

SARS-CoV-2 antibodies in breast milk: Study

Study lays out challenges of achieving equity in communication for diverse patients at hospital discharge

A path to treat currently untreatable cases of cystic fibrosis is clearly achievable, study suggests

Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication

Tissue-specific genetic interactions drive different types of cancer development

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

Brain signals translated into speech give paralyzed man back his words

COVID-19 researchers review 184 drug repurposing candidates

Antihypertension drug may benefit patients with neurofibromatosis type 2

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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