Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Genetically modified tomatoes mimic actions of good cholesterol

UCLA researchers have genetically engineered tomatoes to produce a peptide that mimics the actions of good cholesterol when consumed.

20 Mar 2013

New biodegradable nanoparticles deliver inflammation-resolving drugs to sites of tissue injury

A multicenter team of researchers, including scientists at Columbia University Medical Center (CUMC), Brigham and Women's Hospital (BWH), Mount Sinai School of Medicine, and Massachusetts Institute of Technology, has developed biodegradable nanoparticles that are capable of delivering inflammation-resolving drugs to sites of tissue injury.

20 Mar 2013

Nanomedicines prevent tissue damage associated with atherosclerosis, other chronic diseases

Doses of medicine 100,000 times smaller than the diameter of a human hair prevent the tissue damage associated with atherosclerosis and other chronic diseases in mice.

20 Mar 2013

Interventional endovascular therapy is safe but does not improve MS outcomes: Study

The first controlled clinical trial to test the safety and efficacy of interventional endovascular therapy on the symptoms and progression of multiple sclerosis has found that the intervention, sometimes called the "liberation treatment," which has attracted intense interest in the global MS community, does not improve patient outcomes. In a few cases, the treatment made symptoms worse.

16 Mar 2013

Addition of niacin to statin does not improve HDL function

While two large clinical trials recently showed that adding niacin to statin therapy failed to improve clinical outcomes despite a significant increase in HDL-C levels, little is known about exactly why the increased HDL-C levels did not reduce the risk of cardiovascular events, including heart attack and stroke.

12 Mar 2013

Darapladib can significantly reduce leaks in the blood brain barrier

A research team led by Robert Nagele, PhD, of the New Jersey Institute for Successful Aging (NJISA) at the University of Medicine and Dentistry of New Jersey (UMDNJ)-School of Osteopathic Medicine, has demonstrated that the anti-atherosclerosis drug darapladib can significantly reduce leaks in the blood brain barrier.

12 Mar 2013

Mummies provide important twist in understanding atherosclerotic vascular disease

Like nearly 4.6 million Americans, ancient hunter-gatherers also suffered from clogged arteries, revealing that the plaque build-up causing blood clots, heart attacks and strokes is not just a result of fatty diets or couch potato habits, according to new research in the journal The Lancet.

11 Mar 2013

Inclacumab reduces damage to heart muscle during angioplasty

A single dose of an investigational anti-inflammatory drug called inclacumab considerably reduces damage to heart muscle during angioplasty (the opening of a blocked artery), according to a recent international clinical trial spearheaded by Dr. Jean-Claude Tardif, Director of the Research Centre at the Montreal Heart Institute, affiliated with the University of Montreal.

11 Mar 2013

Patients with PTSD more likely to develop insulin resistance, metabolic syndrome and heart disease

Patients diagnosed with post-traumatic stress disorder (PTSD) have a significantly higher risk of developing insulin resistance and metabolic syndrome, placing them at greater risk for heart disease and diabetes, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session. Researchers say public health interventions are urgently needed to prevent PTSD-related metabolic disorder at its early, reversible stage.

8 Mar 2013

Researchers discover significant crisis-period spike in heart attacks in Greece

Heart attack rates have spiked in Greece since the start of the country's financial crisis, especially among women and residents older than 45, according to a study of patient records being presented at the American College of Cardiology's 62nd Annual Scientific Session.

8 Mar 2013

Carbamylation contributes to heart disease risk among patients with CKD undergoing dialysis

Kidney failure affects 25 million individuals in the U.S. and many more throughout the world. Loss of kidney function means the majority of these patients must undergo dialysis treatments to remove excess fluids and waste products. Although dialysis therapy coupled with medication has improved the life expectancy for people with kidney failure, for unknown reasons, patients' risk of sudden heart failure and death remains 10 to 20 times greater than average.

7 Mar 2013

High HDL levels block development of aneurysms in the aorta

New research provides early evidence that 'good' cholesterol may possess anti-aneurysm forming properties. In laboratory-based investigations, scientists found that increased levels of high-density lipoproteins (HDL), the so-called good cholesterol, blocked the development of aneurysms - dangerous 'ballooning' in the wall of a blood vessel - in the body's largest artery, the aorta.

7 Mar 2013

Study shows how high shear stress could cause VWF to change shape and form blood clots

New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots.

6 Mar 2013

Heart disease signs in newborns of overweight and obese mothers

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4 Mar 2013

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.

4 Mar 2013

Researchers identify mechanisms that connect variety of diseases linked with inflammation

A study led by researchers at Boston University School of Medicine (BUSM) has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation.

3 Mar 2013

Heart-healthy habits at young age can help prevent future cardiovascular disease

Adults are not the only ones who should focus on good heart health. One University of Alabama at Birmingham (UAB) primary care physician said starting heart-healthy habits at a young age can help build a future free from cardiovascular disease.

27 Feb 2013

A good night's sleep can also help promote cardiovascular health

Cutting back on sodium and increasing physical activity are not the only ways to improve heart health - a good night's sleep can also help promote cardiovascular health. One expert at the University of Alabama at Birmingham (UAB) says not getting enough sleep can have harmful heart-health effects.

24 Feb 2013

Familial Hypercholesterolaemia patients often inherit small-effect changes in several genes rather than a large-effect mutation in a single gene

Research published Online First in The Lancet provides new evidence that a substantial proportion of individuals with a clinical diagnosis of Familial Hypercholesterolaemia (FH) inherit a combination of small-effect changes in several genes (polygenic) rather than a large-effect mutation in a single gene (monogenic).

22 Feb 2013

Calcium supplement intake may increase risk of death from heart disease in men

In a new study from the National Institutes of Health, startling results showed that men who took calcium supplements were more apt to die of heart disease than those who didn't get extra calcium in supplement form.

20 Feb 2013

Atherosclerosis News and Research

Further Reading

Genetically modified tomatoes mimic actions of good cholesterol

New biodegradable nanoparticles deliver inflammation-resolving drugs to sites of tissue injury

Nanomedicines prevent tissue damage associated with atherosclerosis, other chronic diseases

Interventional endovascular therapy is safe but does not improve MS outcomes: Study

Addition of niacin to statin does not improve HDL function

Darapladib can significantly reduce leaks in the blood brain barrier

Mummies provide important twist in understanding atherosclerotic vascular disease

Inclacumab reduces damage to heart muscle during angioplasty

Patients with PTSD more likely to develop insulin resistance, metabolic syndrome and heart disease

Researchers discover significant crisis-period spike in heart attacks in Greece

Carbamylation contributes to heart disease risk among patients with CKD undergoing dialysis

High HDL levels block development of aneurysms in the aorta

Study shows how high shear stress could cause VWF to change shape and form blood clots

Heart disease signs in newborns of overweight and obese mothers

Study finds how to shut down Bcl6 in diffuse large B-cell lymphoma

Researchers identify mechanisms that connect variety of diseases linked with inflammation

Heart-healthy habits at young age can help prevent future cardiovascular disease

A good night's sleep can also help promote cardiovascular health

Familial Hypercholesterolaemia patients often inherit small-effect changes in several genes rather than a large-effect mutation in a single gene

Calcium supplement intake may increase risk of death from heart disease in men

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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