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Scientific statement highlights the uncertainty about health effects of marijuana

Despite the perception that marijuana is harmless, there is some scientific evidence challenging that belief, and there are many unanswered questions about its impact on brain health, according to a new American Heart Association scientific statement published today in the Association's journal Stroke.

10 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Scientists have a new understanding of the protective effects of caffeine on the cardiovascular system. While its stimulant effects have long been characterized, a team of Canadian researchers have discovered how caffeine interacts with key cellular factors to remove cholesterol from the bloodstream.

10 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Researchers reveal new therapeutic way to block oncogenic RAS mutants

As a 10-year journey comes to fruition, MUSC Hollings Cancer Center researcher John O'Bryan, Ph.D., and colleagues have demonstrated a new therapeutic way to block a protein that is frequently mutated in cancers.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

In a recent study published in the journal ACS Applied Bio Materials, researchers demonstrated the inhibitory potential of curcumin-encapsulated polysaccharide nanoparticles (CUR−PS-NPs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV2-SP)-stimulated cytokine storm in lung and liver epithelial cells.

8 Feb 2022

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

In a recent study posted to the Research Square preprint* server, a team of researchers investigated the toxicity and absorption, distribution, metabolism, and excretion (ADME) characteristics of a potent herbal drug, taraxerol, in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The paper is under consideration for publication in the Structural Chemistry journal.

7 Feb 2022

Cocktail of two chemicals could help slow down age-related muscular decline

Researchers from Tokyo Metropolitan University have shown that a mixture of 5-aminolevulinic acid(5-ALA) hydrochloride and sodium ferrous citrate (SFC) helps slow down aging-related muscular decline in fruit flies, leading to a slower decline in locomotor activity and longer lifespans.

7 Feb 2022

Stigma around birth defects still plagues people in Africa

Cynthia Solomon, a 45-year-old businesswoman in Nigeria, started having issues in her matrimonial home when she gave birth to two children with Down syndrome.

1 Feb 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Study explores how cannabis use affects driving performance

The steady rise in the use of cannabis - 18 states have legalized recreational use, 13 have decriminalized its use and 36 have medical cannabis laws - has provoked myriad questions and concerns about public health implications, including how cannabis may affect the abilities, real and perceived, of drivers under the influence.

26 Jan 2022

Macromolecular gel with therapeutic payload could halt or slow post-traumatic osteoarthritis

Osteoarthritis affects over 32 million Americans, levying a huge cost on society. Unfortunately, other than analgesics, no pharmaceutical therapy exists that can slow or halt disease progression of a major subset of OA: post-traumatic osteoarthritis (PTOA).

26 Jan 2022

Study reveals a widening gender gap in the field of family medicine due to COVID-19

As people transitioned to working from home at the onset of the coronavirus pandemic, journal submissions from academics increased across the board. But a new study from Northwestern University found as men's scholarly productivity increased, women physicians were submitting less.

25 Jan 2022

Compound News and Research

Scientific statement highlights the uncertainty about health effects of marijuana

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers reveal new therapeutic way to block oncogenic RAS mutants

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

Cocktail of two chemicals could help slow down age-related muscular decline

Stigma around birth defects still plagues people in Africa

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Study reveals potential mechanism for iron accumulation in the aging brain

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Study reveals link between muscular dystrophy and sphingolipids

Study explores how cannabis use affects driving performance

Macromolecular gel with therapeutic payload could halt or slow post-traumatic osteoarthritis

Study reveals a widening gender gap in the field of family medicine due to COVID-19

Peptide-enhanced antibody therapy may help treat breast cancer metastasis to bone

Broccoli compound triggers controlled cell death and recycling of cellular components in fission yeast

Novel compound found in mussels helps increase the durability of dental fillings

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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