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Severity of asthma depends on genetic profile and air pollution

Asthma patients, with a specific genetic profile, exhibit more intense symptoms following exposure to traffic pollution, according to researchers at the National Institutes of Health and collaborators. The study appeared online in Scientific Reports.

31 Aug 2018

Restricting food to 10-hour window can lead to better health

Scientists at the Salk Institute found that mice lacking the biological clocks thought to be necessary for a healthy metabolism could still be protected against obesity and metabolic diseases by having their daily access to food restricted to a 10-hour window.

31 Aug 2018

Research group aims to offer more personalized treatments for pediatric cancers

A new Emmy Noether Independent Junior Research Group at Charité - Universitätsmedizin Berlin is studying the development of pediatric cancers. The research group is being funded by the German Research Foundation (DFG) and will receive €1.7 million over five years.

31 Aug 2018

A genetic signal-transmission system for the gut microbiome

More than 1,000 species of bacteria have been identified in the human gut, and understanding this incredibly diverse "microbiome" that can greatly impact health and disease is a hot topic in scientific research.

31 Aug 2018

Novel approaches for personalized risk prognosis and individualized treatment of NAFLD

More and more adults - but also about 34 percent of obese children - suffer from non-alcoholic fatty liver disease. An unhealthy lifestyle with little physical activity and a diet high in fat, sugar and fructose and/or a genetic predisposition can be the underlying caus.

31 Aug 2018

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Arrowhead Pharmaceuticals Inc. today announced that it has completed dosing of a Phase 1 clinical study of ARO-AAT, the company's second generation subcutaneously administered RNA interference therapeutic being developed as a treatment for a rare genetic liver disease associated with alpha-1 antitrypsin deficiency.

31 Aug 2018

Researchers predict how splicing errors impact disease risk

No one knows how many times in a day, or even an hour, the trillions of cells in our body need to make proteins.

31 Aug 2018

Neurons play active role in triggering a defense mechanism that leads to their own damage

Rasmussen's encephalitis is a rare autoimmune disease that primarily affects children and can lead to seizures.

31 Aug 2018

New survey reveals public attitudes towards commercial use of genetic data samples

The almost 5 million people who paid to get their DNA analyzed by the company 23andMe recently found out that their genetic data and related health information might have been sold to a major drug company.

31 Aug 2018

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Commercial antidepressants typically take two to four weeks to have a significant effect on a depressed patient. They are also inneffective in approximately 40% of the cases.

31 Aug 2018

Muscle dystrophy treatment in dogs with Crispr gene editing

Researchers in the United States have shown that genetically caused muscular dystrophy in dogs could be corrected using genetic editing tools. Muscular dystrophy is one of the most common fatal genetic conditions seen in children and is also seen in dogs

31 Aug 2018

Study raises possibility of detecting childhood bone cancers earlier

Scientists have discovered that some childhood bone cancers start growing years before they are currently diagnosed.

30 Aug 2018

New genetic marker could improve diagnosis of prostate cancer

Scientists have discovered a link between certain genetic mutations, the aggressiveness of prostate cancer, risk of developing the disease and poorer survival rates of patients.

30 Aug 2018

Researchers provide new virulence clues through genomic study of anthrax strains

By analyzing genomic sequences from more than 400 strains of the bacterium that causes anthrax, researchers have provided the first evidence that the severity - technically known as virulence - of specific strains may be related to the number of copies of certain plasmids they carry.

30 Aug 2018

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the European Commission (EC) has granted marketing authorization for ONPATTRO (patisiran) for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

30 Aug 2018

Modified T lymphocytes prevent nerve cell damage in encephalitis

Scientists have found a way to prevent neuron death in Rasmussen’s encephalitis, by exploiting T lymphocytes in the immune system.

30 Aug 2018

Experts discuss potential of maintaining cognitive function through dietary intake

Aging is a highly complex process marked by a succession of events that may lead to an altered brain function, including neurodegenerative diseases. To date, the precise cause of cognitive decline remains quite elusive.

30 Aug 2018

Vertex, Genomics team up to improve discovery of precision medicines

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Genomics plc today announced a three-year collaboration, extendable to five years, to use human genetics and machine learning to improve discovery of targets for precision medicines, and to advance understanding of the clinical impact of human genetic variation and patient stratification in diseases with significant unmet need.

30 Aug 2018

$Genetics study uncovers key factors for fracture risk in osteoporosis$

Genetics study uncovers key factors for fracture risk in osteoporosis

The largest study ever to investigate the genetics of osteoporosis and fracture risk determined that only two examined factors - bone mineral density and muscle strength - play a potentially causal role in the risk of suffering osteoporotic fracture, a major health problem affecting more than 9 million people worldwide very year.

30 Aug 2018

Genetic News and Research

Severity of asthma depends on genetic profile and air pollution

Restricting food to 10-hour window can lead to better health

Research group aims to offer more personalized treatments for pediatric cancers

A genetic signal-transmission system for the gut microbiome

Novel approaches for personalized risk prognosis and individualized treatment of NAFLD

Arrowhead completes dosing of ARO-AAT Phase 1 study to treat rare genetic liver disease

Researchers predict how splicing errors impact disease risk

Neurons play active role in triggering a defense mechanism that leads to their own damage

New survey reveals public attitudes towards commercial use of genetic data samples

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Muscle dystrophy treatment in dogs with Crispr gene editing

Study raises possibility of detecting childhood bone cancers earlier

New genetic marker could improve diagnosis of prostate cancer

Researchers provide new virulence clues through genomic study of anthrax strains

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Modified T lymphocytes prevent nerve cell damage in encephalitis

Experts discuss potential of maintaining cognitive function through dietary intake

Vertex, Genomics team up to improve discovery of precision medicines

Genetics study uncovers key factors for fracture risk in osteoporosis

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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