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KRAS gene mutation recruits second player to trigger pancreatic cancer

More than a cancer-causing gene is needed to trigger pancreatic cancer, a study led by Mayo Clinic has found. A second factor creates a "perfect storm" that allows tumors to form, the researchers say. The study, published in the Sept. 10 issue of Cancer Cell, overturns the current belief that a mutation in the KRAS oncogene is enough to initiate pancreatic cancer and unrestrained cell growth.

11 Sep 2012

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

Dogs with hemangiosarcoma that were treated with a compound derived from the Coriolus versicolor mushroom had the longest survival times ever reported for dogs with the disease.

11 Sep 2012

P5091 molecule triggers apoptosis in drug-resistant myeloma cells

A molecule that targets the cell's machinery for breaking down unneeded proteins can kill multiple myeloma cancer cells resistant to the frontline drug Velcade, researchers at Dana-Farber Cancer Institute have found.

11 Sep 2012

HIF-1 activity directly responsible for spread of breast cancer to lymph vessels

The invasion of cancer cells into the lymph vessels that connect the breast to surrounding lymph nodes is the first step leading to the metastasis, or spread, of cancer throughout the body. Metastasis is the primary cause of breast cancer deaths. Surprisingly little is known about the control of this process and how it might be interrupted to prolong the lives of women with breast cancer.

11 Sep 2012

Combining two drugs may offer new and potent punch against cancer and other diseases

A new study by researchers at Weill Cornell Medical College shows combining two already-FDA approved drugs may offer a new and potent punch against diseases in which blood vessel growth is abnormal -- such as cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis.

11 Sep 2012

'No malignancy risk' with biologic response modifiers

Rheumatoid arthritis patients treated with biologic response modifiers for at least 6 months do not have a greater risk for malignancy than those given other disease-modifying drugs or placebo, conclude US and Spanish researchers.

10 Sep 2012

Enzymatic sculpting process used to isolate and concentrate cells from whole blood

In living systems, complex nano- and microscale structures perform a host of physical and biological functions. While two-dimensional patterns can be recreated fairly well with techniques like microlithography, three-dimensional structures represent a big challenge.

10 Sep 2012

Researchers identify many potential therapeutic targets for squamous cell lung cancers

A new paper published online in Nature holds out hope that people with the second most common type of lung cancer may one day benefit from targeted therapies that have transformed treatments for other lung cancer patients.

10 Sep 2012

Scientists characterize the lung squamous cell carcinoma genome

In the September 9, 2012 early online edition of Nature, scientists with The Cancer Genome Atlas (TCGA) report that they have characterized the lung squamous cell carcinoma genome.

10 Sep 2012

Novel surgical technique removes invasive facial tumor, recreates functional lower jaw and mouth

Using a novel surgical approach, it's possible to rebuild a functional lower jaw and mouth, and preserve a patient's ability to eat and speak after removing an invasive facial tumor, according to a new report from Henry Ford Hospital in Detroit.

10 Sep 2012

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

A nationwide consortium of scientists has reported the first comprehensive genetic analysis of squamous cell carcinoma of the lung, a common type of lung cancer responsible for about 400,000 deaths each year.

10 Sep 2012

Study investigates effects of acidity on breast and pancreatic cancer cell lines

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Wayne State University have discovered that tumor cell survival relies on adaptation to acidic conditions in the tumor microenvironment.

7 Sep 2012

Crizotinib effective in shrinking tumors in patients with ALK positive non-small cell lung cancer

Crizotinib is effective in shrinking tumors in patients with anaplastic lymphoma receptor tyrosine kinase (ALK) positive non-small cell lung cancer, a cancer commonly found in people who never smoked, and should be the standard of care for advanced stages of this disease, according to research presented at the 2012 Chicago Multidisciplinary Symposium in Thoracic Oncology.

7 Sep 2012

Melanoma manifests differently in children than in adults

Melanoma, newly diagnosed in more than 76,000 Americans in 2011, is the most common and dangerous form of skin cancer. Melanoma is rare in children, accounting for 1 to 4 percent of all melanoma cases and just 3 percent of pediatric cancers. Just as adult cases of melanoma are increasing, pediatric melanoma is rising at the rate of 1 to 4 percent per year.

7 Sep 2012

OncoMed announces data from demcizumab preclinical study on pancreatic cancer

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer, today announced the online publication in Clinical Cancer Research of preclinical data demonstrating the potent anti-cancer activity of anti-DLL4 (demcizumab) in patient-derived pancreatic tumor models.

7 Sep 2012

RSV virus selectively kills cancer cells

RSV, a virus that causes respiratory infections in infants and young children, selectively kills cancer cells while leaving healthy cells alone, researchers from the School of Medicine at The University of Texas Health Science Center San Antonio said.

7 Sep 2012

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Newly discovered molecular differences between small cell lung cancer and nonsmall cell lung cancer have revealed PARP1 and EZH2 as potential therapeutic targets for patients with small cell lung cancer, according to the results of a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

7 Sep 2012

Reduced NF-κB expression linκed to postradiation oral mucosa vulnerability

The fragility of oral mucosa after radiotherapy for oral squamous cell carcinoma may be due to the inhibition of the DNA transcriptor protein nuclear factor κappa-light-chain-enhancer of activated B cells, show study findings.

6 Sep 2012

Researchers identify HIF2α gene mutation in cancer tumor cells

For the first time, a mutation in HIF2α, a specific group of genes known as transcription factors that is involved in red blood cell production and cell metabolism, has been identified in cancer tumor cells.

6 Sep 2012

Thomas Jefferson University Hospitals performs 500th Whipple procedure

Thomas Jefferson University Hospital continues to be the leader in the region in fighting the deadliest of cancers—pancreatic cancer. In August, Charles J. Yeo, MD, FACS, the Samuel D. Gross Professor and Chair of Surgery, and a co-director of the Jefferson Pancreas, Biliary and Related Cancer Center, performed his 500th Whipple procedure at Thomas Jefferson University Hospitals, a life-saving surgery for those suffering with the disease.

6 Sep 2012

Tumor News and Research

KRAS gene mutation recruits second player to trigger pancreatic cancer

Polysaccharopeptide improves survival in dogs with hemangiosarcoma

P5091 molecule triggers apoptosis in drug-resistant myeloma cells

HIF-1 activity directly responsible for spread of breast cancer to lymph vessels

Combining two drugs may offer new and potent punch against cancer and other diseases

'No malignancy risk' with biologic response modifiers

Enzymatic sculpting process used to isolate and concentrate cells from whole blood

Researchers identify many potential therapeutic targets for squamous cell lung cancers

Scientists characterize the lung squamous cell carcinoma genome

Novel surgical technique removes invasive facial tumor, recreates functional lower jaw and mouth

Scientists report first comprehensive genetic analysis of lung squamous cell carcinoma

Study investigates effects of acidity on breast and pancreatic cancer cell lines

Crizotinib effective in shrinking tumors in patients with ALK positive non-small cell lung cancer

Melanoma manifests differently in children than in adults

OncoMed announces data from demcizumab preclinical study on pancreatic cancer

RSV virus selectively kills cancer cells

Study finds PARP1 and EZH2 as potential therapeutic targets for small cell lung cancer

Reduced NF-κB expression linκed to postradiation oral mucosa vulnerability

Researchers identify HIF2α gene mutation in cancer tumor cells

Thomas Jefferson University Hospitals performs 500th Whipple procedure

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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