Atherosclerosis News and Research

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Atherosclerosis is the progressive buildup of plaque - the fatty deposits and other cells - in the inner walls of the arteries. The condition is a consequence of elevated cholesterol and for many it's a silent disease, with no visible signs or symptoms. The disease can begin in early adulthood and continues to progress for the rest of a person's life. Despite the serious nature of atherosclerosis, many people do not understand how it develops and progresses.

Study assesses ischaemic and haemorrhagic risk linked with history of stroke or TIA

Heart and cerebro-vascular disorders represent the two leading causes of death throughout the world. They are sometimes combined in a single patient and their combination represents both a considerable risk to the patient and a therapeutic challenge.

20 Feb 2013

High coronary artery calcium together with slow walking speed multiplies risk of mortality

High coronary artery calcium (CAC) together with slow walking speed multiplies the risk of mortality, reveals a new study published in the International Journal of Cardiology. Coronary artery disease is the leading cause of death worldwide and also a common cause of sudden death - heart attack often being the first sign of the disease.

20 Feb 2013

CCR1 and CCR5 receptors play a crucial role in atherosclerosis

Atherosclerosis is one of the commonest causes of death in modern societies. The condition is characterized by the build-up of fatty deposits called atherosclerotic plaques on the inner surfaces of arteries, which restrict, and may eventually cut off, blood flow. The deposits can also be dislodged from their site of origin and may then block major vessels in the heart or the brain, leading to life-threatening myocardial infarction or stroke.

20 Feb 2013

Coronary computed tomography angiography effectively determines risk of heart attacks

Coronary computed tomography angiography (CCTA) is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors, such as high cholesterol or high blood pressure, according to a new study published online in the journal Radiology.

19 Feb 2013

ADAMTS7 enzyme plays a crucial role in coronary heart disease

Scientists investigating how certain genes affect an individual's risk of developing coronary heart disease have identified a new therapeutic target, according to research published today in The American Journal of Human Genetics.

15 Feb 2013

Researchers discover miR-27b that regulates lipid levels in the blood

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia-abnormal blood cholesterol levels that can contribute to heart disease.

11 Feb 2013

LPA genetic variant increases risk of heart valve calcification

Researchers have found a genetic variant that doubles the likelihood that people will have calcium deposits on their aortic valve. Such calcification, if it becomes severe, can cause narrowing or a blockage of the aortic valve, a condition called aortic stenosis.

9 Feb 2013

Tumor necrosis factor receptor 2 involved in renal decline in diabetes

Researchers have found that circulating levels of tumor necrosis factor receptor 2 are independently associated with the development of chronic kidney disease in nonobese Japanese patients with Type 2 diabetes.

8 Feb 2013

Liver gene found to regulate cholesterol and fat blood levels

Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia—abnormal blood cholesterol levels that can contribute to heart disease.

7 Feb 2013

Study: 10 to 15% of people with TIAs will experience strokes within three months

Each year, as many as 500,000 Americans experience mini strokes called transient ischemic attacks (TIAs). Symptoms quickly go away, usually within an hour, and many people don't seek treatment. But 10 to 15 percent of people who experience TIAs will experience full-blown strokes within three months, and 40 percent of these strokes will occur in the first 24 hours, according to an article by three Loyola University Medical Center neurologists in the journal Expert Review of Neurotherapeutics.

6 Feb 2013

Patients undergoing major vascular surgery procedures are at increased risk of stroke

Patients undergoing major vascular surgery procedures are at increased risk of stroke, leading to a high mortality rate and prolonged hospitalization, according to a study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

6 Feb 2013

Synageva announces 12-week data from sebelipase alfa Phase I/II study on LAL Deficiency

Synageva BioPharma Corp. (Synageva), a clinical stage biopharmaceutical company developing therapeutic products for rare diseases, today announced publication of the 12-week Phase I/II extension study data of sebelipase alfa in adults with lysosomal acid lipase deficiency (LAL Deficiency) in the online version and an upcoming print edition of Hepatology

5 Feb 2013

Scientists receive honorary doctorate for research on Alzheimer's disease

On Monday 4 February, Dennis J. Selkoe and five other "brain teasers" will receive an honorary doctorate from the KU Leuven. The promoters for this honorary doctorate - VIB-KU Leuven professors Bart De Strooper and Wim Robberecht - will honor Dennis J. Selkoe for his scientific insights, but also for his relentless search for new medicines to treat Alzheimer's Disease and other conditions that cause severe damage in the brain.

4 Feb 2013

Increasing age, male sex and adiposity risk factors for metabolic syndrome in children

Metabolic syndrome is more likely to affect children who are obese than overweight or non-overweight and who have other characteristics associated with the disorder, such as high blood pressure or insulin resistance. A new comprehensive and systematic review of the medical literature on metabolic syndrome in children that probed deeper to evaluate the risk associated with gender, ethnicity, and geography was published in Metabolic Syndrome and Related Disorders, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

31 Jan 2013

Minimally invasive islet transplantation reverses progression of atherosclerosis in type 1 diabetics

Minimally invasive islet transplantation for patients with type 1 diabetes achieves insulin independence and reverses the progression of atherosclerosis in the first few years after transplant, according to a University of Illinois at Chicago study.

29 Jan 2013

AF implicated in sudden cardiac death

People who develop atrial fibrillation are at more than twice the usual risk for sudden cardiac death, reveal US study findings published in JAMA Internal Medicine.

28 Jan 2013

Snoring may indicate future health risks

Here's a wake-up call for snorers: Snoring may put you at a greater risk than those who are overweight, smoke or have high cholesterol to have thickening or abnormalities in the carotid artery, according to researchers at Henry Ford Hospital in Detroit.

25 Jan 2013

Mitsubishi Tanabe Pharma in-licenses CETP inhibitor to Dezima Pharma

Dezima Pharma ('Dezima'), the biotechnology company developing innovative drugs in the field of dyslipidemia, announced today the in-licensing of a cholesteryl ester transfer protein (CETP) inhibitor DEZ-001 (formerly TA-8995) from Mitsubishi Tanabe Pharma Corporation (MTPC). Terms of the deal were not disclosed.

22 Jan 2013

Arterial elasticity link to lung function

People with reduced arterial elasticity may have impaired lung function, and vice versa, say US researchers.

8 Jan 2013

Subclinical hypothyroidism not a risk factor for heart disease

Persistent subclinical hypothyroidism in older adults is not associated with an increased risk for cardiovascular events, US research shows.

28 Dec 2012

Atherosclerosis News and Research

Further Reading

Study assesses ischaemic and haemorrhagic risk linked with history of stroke or TIA

High coronary artery calcium together with slow walking speed multiplies risk of mortality

CCR1 and CCR5 receptors play a crucial role in atherosclerosis

Coronary computed tomography angiography effectively determines risk of heart attacks

ADAMTS7 enzyme plays a crucial role in coronary heart disease

Researchers discover miR-27b that regulates lipid levels in the blood

LPA genetic variant increases risk of heart valve calcification

Tumor necrosis factor receptor 2 involved in renal decline in diabetes

Liver gene found to regulate cholesterol and fat blood levels

Study: 10 to 15% of people with TIAs will experience strokes within three months

Patients undergoing major vascular surgery procedures are at increased risk of stroke

Synageva announces 12-week data from sebelipase alfa Phase I/II study on LAL Deficiency

Scientists receive honorary doctorate for research on Alzheimer's disease

Increasing age, male sex and adiposity risk factors for metabolic syndrome in children

Minimally invasive islet transplantation reverses progression of atherosclerosis in type 1 diabetics

AF implicated in sudden cardiac death

Snoring may indicate future health risks

Mitsubishi Tanabe Pharma in-licenses CETP inhibitor to Dezima Pharma

Arterial elasticity link to lung function

Subclinical hypothyroidism not a risk factor for heart disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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