Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

Aspirin can prevent stroke and heart attacks: Study

In a large scale Australian study, researchers have found that Aspirin can save lives and drastically reduce rates of stroke and heart attack.

15 Sep 2010

FDA approves Krystexxa drug to treat gout

The U.S. Food and Drug Administration approved Krystexxa (pegloticase) to treat the painful condition known as gout in adults who do not respond to or who cannot tolerate conventional therapy.

15 Sep 2010

Cell-enriched primary renal cells improve survival and augment kidney function in CKD rodents

Tengion, Inc., a leader in regenerative medicine, announced today the publication of a key study in the American Journal of Physiology Renal Physiology by researchers at Tengion. In the study, rodents with chronic kidney disease (CKD) were treated with healthy kidney cells to catalyze the regeneration of functional kidney tissue and delay disease progression, as evidenced by extended survival, improved kidney filtration, and reduced severity of kidney tissue pathology.

14 Sep 2010

Study finds new therapeutic target for polycystic kidney disease

In work suggesting a new approach to treating polycystic kidney disease (PKD), a leading cause of kidney failure, researchers at Children's Hospital Boston were able to block the formation of fluid-filled cysts, the hallmark of the disease, in a mouse model. Their findings, using a compound that inhibits a receptor known as c-Met, will be published in the September 13th online edition of the Journal of Clinical Investigation.

14 Sep 2010

Covidien supports FDA labeling changes for gadolinium-based contrast agents

Covidien, a leading global provider of healthcare products, today announced it supports the U.S. Food and Drug Administration's (FDA) labeling changes for gadolinium-based contrast agents for patients with acute kidney injury or chronic, severe kidney disease.

13 Sep 2010

Clinica of Virginia offers medical services to Medicare and Medicaid patients for $1.00

In an effort to promote wellness and help those who are struggling to make ends meet, Clinica of Virginia, LLC. is providing quality medical services to Medicare and Medicaid patients for only $1.00. The national economic downturn, combined with national bureaucracy, has created a shortage of physicians and clinics who accept Medicare and Medicaid. Chronic, multiple medical conditions plague those Americans who can financially afford it the least, and physicians' offices who accept Medicare or Medicaid are now far and few between. Clinica accepts both.

10 Sep 2010

Lantheus Medical Imaging supports FDA action to ensure appropriate use of gadolinium-based contrast agents

Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic medical imaging, supports the U.S. Food and Drug Administration's (FDA) announcement requiring safety-related label changes for all gadolinium-based contrast agents to highlight the rare and potentially fatal condition known as nephrogenic systemic fibrosis (NSF).

10 Sep 2010

GBCAs carry new warnings on their labels about risk of NSF: FDA

The U.S. Food and Drug Administration is requiring that gadolinium-based contrast agents (GBCAs) carry new warnings on their labels about the risk of a rare and potentially fatal condition known as nephrogenic systemic fibrosis, if the drug is administered to certain patients with kidney disease.

10 Sep 2010

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today that it has initiated a Phase 2a clinical study of PRM-151 to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery. There currently are no approved drugs for preventing post-surgical scarring in glaucoma, and there are no approved anti-fibrotic drug therapies in the U.S. or Europe for any fibrotic disease.

7 Sep 2010

Risk of late onset TRAS in living unrelated donor kidney recipients

Patients who have received a new kidney are significantly more likely to develop transplant renal artery stenosis (TRAS) if they are obese or over 50, according to research published in the September issue of the Journal of Renal Care.

7 Sep 2010

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Kidney transplants that show a combination of fibrosis (scarring) and inflammation after one year are at higher risk of long-term transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

3 Sep 2010

Researchers unveil prototype model of first implantable artificial kidney

UCSF researchers today unveiled a prototype model of the first implantable artificial kidney, in a development that one day could eliminate the need for dialysis.

3 Sep 2010

Blood pressure treatment may prevent end-stage kidney disease in some patients: Study

Intensively treating hypertension in some African Americans with kidney disease by pushing blood pressure well below the current recommended goal may significantly decrease the number who lose kidney function and require dialysis, suggests a Johns Hopkins-led study publishing in the New England Journal of Medicine Thursday.

2 Sep 2010

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

Kidney failure may accompany or complicate transplantation of the liver, heart, or lung. Because increasing numbers of individuals are receiving non-kidney transplants, researchers have wondered whether more of such patients are being listed for kidney transplants.

2 Sep 2010

RLY5016 potassium binder helps to regulate hyperkalemia in heart failure patients

Results from a recent phase 2b clinical trial may provide a new approach to managing excess potassium levels in patients with heart failure and heart failure with chronic kidney disease.

30 Aug 2010

Hemoglobin variability does not increase mortality in European hemodialysis patients: Study

Fluctuations in blood composition that often arise from commonly used therapies among kidney disease patients are not an independent predictor of adverse outcomes for European hemodialysis patients, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology. The results suggest that although hemoglobin variability is common in kidney disease patients, it does not appear to increase their likelihood of dying early.

27 Aug 2010

CFHR5 nephropathy linked to genetic mutation in innate immune system

A rare form of kidney disease linked to a genetic mutation in the innate immune system has been identified by researchers funded by the Wellcome Trust and the Medical Research Council.

26 Aug 2010

Study identifies four genetic variants associated with ESRD disease in Chinese diabetic patients

Examination of a gene involved in cell signaling finds that four common variants of this gene are associated with the development of end-stage renal disease in Chinese patients with type 2 diabetes, according to a study in the August 25 issue of JAMA.

25 Aug 2010

Study finds high glucose level blocks infectious bacteria detection, affects immunity

Research led by the Warwick Medical School at the University of Warwick has found that unhealthy glucose levels in patients with diabetes can cause significantly more problems for the body than just the well-known symptoms of the disease such as kidney damage and circulation problems.

24 Aug 2010

NBA player Alonzo Mourning uses celebrity fame to fight kidney disease

In October 2000, Mourning was diagnosed with focal segmental glomerular sclerosis (FSGS), a kidney disease that causes scarring in the glomeruli, the blood vessels in the kidneys that filter the blood to make urine.

21 Aug 2010

Nephropathy News and Research

Further Reading

Aspirin can prevent stroke and heart attacks: Study

FDA approves Krystexxa drug to treat gout

Cell-enriched primary renal cells improve survival and augment kidney function in CKD rodents

Study finds new therapeutic target for polycystic kidney disease

Covidien supports FDA labeling changes for gadolinium-based contrast agents

Clinica of Virginia offers medical services to Medicare and Medicaid patients for $1.00

Lantheus Medical Imaging supports FDA action to ensure appropriate use of gadolinium-based contrast agents

GBCAs carry new warnings on their labels about risk of NSF: FDA

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Risk of late onset TRAS in living unrelated donor kidney recipients

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Researchers unveil prototype model of first implantable artificial kidney

Blood pressure treatment may prevent end-stage kidney disease in some patients: Study

Non-kidney transplant patients likely to undergo kidney transplant prior to dialysis: Study

RLY5016 potassium binder helps to regulate hyperkalemia in heart failure patients

Hemoglobin variability does not increase mortality in European hemodialysis patients: Study

CFHR5 nephropathy linked to genetic mutation in innate immune system

Study identifies four genetic variants associated with ESRD disease in Chinese diabetic patients

Study finds high glucose level blocks infectious bacteria detection, affects immunity

NBA player Alonzo Mourning uses celebrity fame to fight kidney disease

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