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Mutation in BRCA1 tumor suppressor gene helps develop breast, ovarian cancer: Study

Studies have well established that women who harbor a mutation in the BRCA1 tumor suppressor gene are at greater risk for developing breast and ovarian cancers. Less known is information on other molecular events that may impact cancer formation in cells having a BRCA1 mutation. Investigators from The Cancer Institute of New Jersey and a number of major cancer centers in Europe have identified the role a key protein plays in helping cells with mutant BRCA1 genes to survive.

20 May 2010

Quest PharmaTech net consolidated loss for 2010 increases to $517,799

Quest PharmaTech Inc., a pharmaceutical company developing and commercializing products for the treatment of cancer, today announced financial and operational results for the fiscal year ended January 31, 2010.

20 May 2010

Over-expression of Stat5 protein leads to deadly spread of prostate cancer: Study

Researchers from the Kimmel Cancer Center at Jefferson have found that Stat5, a signaling protein previously found to be key to survival of prostate cancer, is also involved in metastasis.

20 May 2010

Study confirms inverse association of increase in BMI with lower brain volumes

Researchers from Boston University School of Medicine determined that excess abdominal fat places otherwise healthy, middle-aged people at risk for dementia later in life. Preliminary findings suggest a relationship between obesity and dementia that could lead to promising prevention strategies in the future. Results of this study are published early online in Annals of Neurology, a journal of the American Neurological Association.

20 May 2010

Phase I study of SNS-032 demonstrates safety, potential clinical activity in treating B-cell malignancies

A Phase I clinical trial of SNS-032, one of the first in a new class of drugs that inhibit cyclin-dependent kinases, demonstrated the drug's safety and potential clinical action against advanced chronic lymphocytic leukemia. Cyclin-dependent kinases are enzymatic proteins that are integrally involved in cellular metabolism, renewal and signaling, and are thought to play key roles in the growth of cancers.

20 May 2010

Essen BioScience launches CellPlayer Cell Migration 96-well assay kit

Essen BioScience Inc., a global provider of life science research tools and discovery services, today announced the launch of its CellPlayer™ Cell Migration 96-well assay kit for the IncuCyte™ Live-Cell Imaging System. The expanding line of kinetic CellPlayer assays for the IncuCyte also includes a co-culture assay for Angiogenesis.

From Sartorius 19 May 2010

Results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 to be presented at ASCO 2010

TRACON Pharmaceuticals, a biotechnology company that develops targeted therapies for oncology and ophthalmology, announced today that results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 will be presented at the annual meeting of the American Society of Clinical Oncology on June 5-7, 2010 in Chicago, IL.

19 May 2010

Parents ignore emotional suffering overweight kids experience as teens

Millions of kids who are obese will likely suffer from verbal abuse, societal ostracization, stigmas, health problems and eventually die at a young age. The double calamity will occur if parents continue to avoid the problem and ignore the cries for help from our children, declares Dr. Sasson Moulavi, M.D., founder of the Smart for Life(R) Cookie Diet and its children's lifestyle program THIN ADVENTURE(TM).

19 May 2010

Researchers discover biological pathway signature of ccRCC

By examining expression of every human gene in clear cell renal cell carcinoma compared to normal kidney cells, researchers at Mayo Clinic's campus in Florida have discovered gene signatures they say explain much of the biology of this common and difficult-to-treat kidney cancer.

19 May 2010

New DVS radiation measurement device for prostate cancer treatment

John Theurer Cancer Center at Hackensack University Medical Center announced today that it is one of two cancer centers in the tri-state area currently implanting a wireless radiation sensor, known as DVS. John Theurer Cancer Center radiation oncologists can now receive data immediately post- treatment on the precise amount of radiation being delivered to tumors and surrounding tissue for prostate cancer treatments.

18 May 2010

Article demonstrates single agent activity of KRX-0401 in neuroblastoma tumor preclinical models

Keryx Biopharmaceuticals today announced the publication of an article in the May 12th Journal of the National Cancer Institute, entitled "In Vitro and In Vivo Inhibition of Neuroblastoma Tumor Cell Growth by AKT Inhibitor Perifosine," demonstrating the single agent activity of KRX-0401 (perifosine) in neuroblastoma tumor preclinical models.

18 May 2010

GATC Biotech to sequence samples from pediatric brain tumors for world's largest cancer research project

GATC Biotech to sequence samples from brain tumors in children for the world's largest cancer research project. The aim of the German PedBrainTumor Consortium within the ICGC is to develop innovative diagnostic methods and treatments in order to be able to provide children with therapies which have fewer side effects in future.

18 May 2010

Patients who receive H-SRT for recurrent brain cancer live longer: Researchers

Patients who received hypofractionated stereotactic radiotherapy for their recurrent brain cancers lived longer lives, according to researchers at Thomas Jefferson University.

18 May 2010

152 research and training grants awarded to researchers at 93 institutions nationwide

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 152 new national research and training grants totaling $50,717,000 in the first of two grants cycles for 2010. The grants, primarily to early career researchers, cover a broad range of investigator-initiated ideas at 93 institutions nationwide, from whether cadmium exposure increases the risk of endometrial cancer, to studies of plant and bacterial-bourne compounds, to a study on a protein called survivin that could lead to novel drugs targeting prostate cancer.

18 May 2010

No clear evidence of a mobile phone and brain cancer link

Use of mobile phones has been under scrutiny for a while now with many claiming a link between mobile phone use and brain cancer. The mild radioactive waves generated from mobile phones have so far been poorly understood. There are no known mechanisms by which mobile phone radiation could cause cancer. Unlike x-rays, mobile phone radiation is non-ionising, and is too weak to break apart DNA, which is necessary to induce other cancers. However scientists do agree that this radiation might speed up a growing brain tumor.

17 May 2010

Hawthorn announces licensing deal with University of Pittsburgh for novel monoclonal antibodies for cancer

Hawthorn Pharmaceuticals, Inc. today announced a global licensing deal with the University of Pittsburgh covering a series of novel monoclonal antibodies for cancer. The antibody portfolio targets a variety of cancers through the cell surface chondrotin sulfate proteoglycan 4 (CSPG4), which plays an important role in signaling pathways regulating tumor cell survival, growth, and motility.

17 May 2010

Celldex Therapeutics commences screening in CDX-1307 Phase 2 study for bladder cancer

Celldex Therapeutics, Inc. today announced that the first patient has been screened in a randomized Phase 2 study of the Company's novel, first-in-class antibody-based vaccine candidate from its Precision Targeted Immunotherapy (PTI) platform. This study will evaluate the CDX-1307 regimen in both neoadjuvant and adjuvant settings in patients with newly diagnosed muscle-invasive bladder cancers that express hCG-beta.

17 May 2010

Most recurrences of HCC occur early after initial diagnosis and treatment: Research article

Hepatocellular carcinoma is an aggressive tumor with poor long-term prognosis. The reported 5-year recurrence rate ranges from 75% to 100%. Therefore, extrahepatic metastasis of HCC is uncommon due to the highly malignant nature of the primary tumor. However, with advances in different treatment modalities for HCC, the incidence of extrahepatic metastasis appears to be increasing.

17 May 2010

Researchers identify protein involved in pushing bladder tumors to become invasive

Bladder cancer often becomes aggressive and spreads in patients despite treatment, but now researchers at the Kimmel Cancer Center at Jefferson have identified a protein they believe is involved in pushing tumors to become invasive - and deadly.

15 May 2010

Canadian cancer patients cross the border for second opinion

Two years ago, Beverlee London of Toronto was diagnosed with Stage I lung cancer. London was given the news by her lung specialist in Toronto that she had a malignant tumor on her right lung. She also decided at the time to visit the Barbara Ann Karmanos Cancer Center in Detroit for a second opinion, since she had family living in the area.

15 May 2010

Tumor News and Research

Mutation in BRCA1 tumor suppressor gene helps develop breast, ovarian cancer: Study

Quest PharmaTech net consolidated loss for 2010 increases to $517,799

Over-expression of Stat5 protein leads to deadly spread of prostate cancer: Study

Study confirms inverse association of increase in BMI with lower brain volumes

Phase I study of SNS-032 demonstrates safety, potential clinical activity in treating B-cell malignancies

Essen BioScience launches CellPlayer Cell Migration 96-well assay kit

Results from Phase 1 clinical trials of TRC105, TRC102, and TRC093 to be presented at ASCO 2010

Parents ignore emotional suffering overweight kids experience as teens

Researchers discover biological pathway signature of ccRCC

New DVS radiation measurement device for prostate cancer treatment

Article demonstrates single agent activity of KRX-0401 in neuroblastoma tumor preclinical models

GATC Biotech to sequence samples from pediatric brain tumors for world's largest cancer research project

Patients who receive H-SRT for recurrent brain cancer live longer: Researchers

152 research and training grants awarded to researchers at 93 institutions nationwide

No clear evidence of a mobile phone and brain cancer link

Hawthorn announces licensing deal with University of Pittsburgh for novel monoclonal antibodies for cancer

Celldex Therapeutics commences screening in CDX-1307 Phase 2 study for bladder cancer

Most recurrences of HCC occur early after initial diagnosis and treatment: Research article

Researchers identify protein involved in pushing bladder tumors to become invasive

Canadian cancer patients cross the border for second opinion

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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