Translation News and Research

RSS

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

More than a third of heat-related deaths attributable to human-induced global warming

Between 1991 and 2018, more than a third of all deaths in which heat played a role were attributable to human-induced global warming, according to a new article in Nature Climate Change.

31 May 2021

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

A new study, published in Nano Letters, describes an effective new COVID-19 vaccine candidate based on a messenger ribonucleic acid (mRNA) platform.

28 May 2021

Could the marine compound plitidepsin promote recovery from moderate COVID-19?

A new paper by an international team of researchers describes experimental evidence of the antiviral efficacy of a marine compound called plitidepsin against SARS-CoV-2. The findings show that plitidepsin inhibits SARS-CoV at low concentrations, as observed by a thousand-fold reduction in genomic RNA and viral titers in cells exposed to the virus in culture when treated.

27 May 2021

Prism adaptation treatment enhances functional, cognitive outcomes in people with spatial neglect

A team of experts in post-stroke neurorehabilitation confirmed that including prism adaptation treatment in standard of care for patients with post-stroke spatial neglect improved functional and cognitive outcomes according to the Functional Independence Measure®.

26 May 2021

Researchers identify interventions to improve rehabilitation outcomes for people with spatial neglect

A recent qualitative study of rehabilitation professionals caring for people with spatial neglect enabled researchers to identify interventions to improve rehabilitation outcomes.

25 May 2021

Medical EdTech specialist, Continulus, makes two key strategic hires to boost its finance and technology capability

Continulus, the online video-learning platform for health professionals, has hired Scott McIntosh as CFO and Mark Mace as Software Architect.

From Continulus 24 May 2021

Genetically engineered intestinal organoids reveal potential treatment targets against SARS-CoV-2

Using CRISPR/Cas9 and human intestinal organoids to study genes implicated in the biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), researchers from the Netherlands identified a specific serine protease (TMPRSS2) as an attractive pan-coronavirus therapeutic target. Their exciting findings are available in a study currently available on the bioRxiv* preprint server.

24 May 2021

Penn University more than doubles the percentage of Black patients in cancer clinical trials

A five-year community outreach and engagement effort by the Abramson Cancer Center at the University of Pennsylvania (ACC) to increase enrollment of Black patients into cancer clinical trials more than doubled the percentage of participants, improving access and treatment for a group with historically low representation in cancer research.

21 May 2021

Study may lead to new treatments for a wide range of neurological conditions

New research published today sheds important light on how the production of a key protein in the brain is controlled, which could pave the way for new treatments for a wide range of neurological conditions.

19 May 2021

UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors

Tackling the scar tissue that shields pancreatic tumors from effective drug access is a promising advance in a notoriously hard-to-treat cancer.

17 May 2021

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Researchers in the United States analyzed the non-structural protein 2 (Nsp2) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to better understand its function and to guide future drug discovery. The research paper is currently available on bioRxiv* preprint server.

16 May 2021

Oral TXA is equally efficacious at preventing blood loss in orthopedic surgery, interim study suggests

Interim results of a study conducted by researchers at Hospital for Special Surgery (HSS) suggest that oral tranexamic acid (TXA) is non-inferior to intravenous (IV) TXA in preventing blood loss in total knee and total hip replacement surgery.

14 May 2021

Three-way strategy employed by SARS-CoV-2 during infection

The study, published in the journal Nature, reveals a multi-pronged strategy that the virus employs to ensure its quick and efficient replication while evading the immune system. The study elucidated how the virus can quickly, in a matter of hours, take over the cell's protein-making machinery and parallelly neutralize the cell's antiviral signaling, thus delaying and muddling the immune response.

13 May 2021

UCLA Health wins $750,000 grant to scale COVID-19 innovations and support health equity

UCLA Health has received a $750,000 grant from the U.S. Economic Development Administration to scale healthcare innovations for COVID-19 response and recovery and to support health equity through BioFutures, a new LA County workforce development program for diversity in the biosciences.

13 May 2021

Johns Hopkins expert addresses the impact of pandemic on surgical innovation pipeline and ecosystem

The COVID-19 pandemic has worked havoc on many aspects of society, health care hardly the least among them. In a new study for the journal Surgical Innovation, Associate Professor Toby Gordon of the Johns Hopkins Carey Business School addresses the ways in which the pandemic, as she writes, has "severely weakened the surgical innovation pipeline and ecosystem."

13 May 2021

CNIO researchers unravel why motor neurons die in ALS patients

In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown.

12 May 2021

New translational research platform launched to study rare cancers

The University of Texas MD Anderson Cancer Center and the Broad Institute of MIT and Harvard today announced the launch of a new translational research platform to study rare cancers and develop a first-of-its-kind resource for the scientific community.

11 May 2021

Natural products a rich source for novel antiviral compounds

In a recent review in the journal Viruses, researchers look at natural products that can be identified as potential alternative antiviral agents. The reviewers discussed the antiviral activities of several natural products towards DNA and RNA viruses with an analytical approach. The researchers detailed the cellular/viral targets of the active molecules and their impact on the infection and viral replication cycle.

10 May 2021

Microneedles for cancer immunotherapy may lead to minimal invasiveness, side effects

A recent study from the University of Helsinki monitors the breakthrough progresses in the development of microneedles for immunotherapy and discusses the challenges regarding their production.

6 May 2021

Translation News and Research

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

More than a third of heat-related deaths attributable to human-induced global warming

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

Could the marine compound plitidepsin promote recovery from moderate COVID-19?

Prism adaptation treatment enhances functional, cognitive outcomes in people with spatial neglect

Researchers identify interventions to improve rehabilitation outcomes for people with spatial neglect

Medical EdTech specialist, Continulus, makes two key strategic hires to boost its finance and technology capability

Genetically engineered intestinal organoids reveal potential treatment targets against SARS-CoV-2

Penn University more than doubles the percentage of Black patients in cancer clinical trials

Study may lead to new treatments for a wide range of neurological conditions

UNSW researchers find novel way to attack the 'fortress' surrounding pancreatic tumors

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Oral TXA is equally efficacious at preventing blood loss in orthopedic surgery, interim study suggests

Three-way strategy employed by SARS-CoV-2 during infection

UCLA Health wins $750,000 grant to scale COVID-19 innovations and support health equity

Johns Hopkins expert addresses the impact of pandemic on surgical innovation pipeline and ecosystem

CNIO researchers unravel why motor neurons die in ALS patients

New translational research platform launched to study rare cancers

Natural products a rich source for novel antiviral compounds

Microneedles for cancer immunotherapy may lead to minimal invasiveness, side effects

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News