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Role of alpha tocopherol associated protein in prostate cancer

Researchers have identified a protein that disrupts an important signaling pathway in prostate cancer cells and suppresses growth of the cancer.

1 Nov 2005

EphA2 represents a promising treatment target for glioblastoma multiforme

Researchers at Wake Forest University Baptist Medical Center have identified a second promising treatment target for glioblastoma multiforme, one of the most deadly types of brain tumors. The research results are reported in the October issue of Molecular Cancer Research.

1 Nov 2005

Bumetanide may help treat seizures in newborns

A diuretic drug called bumetanide may serendipitously help treat seizures in newborns, which are difficult to control with existing anticonvulsants, according to a study in the November Nature Medicine.

1 Nov 2005

First study to confirm the benefit of anti-angiogenic therapy in patients with breast cancer

Results from the first and only interim analysis of an important trial assessing the potential of Herceptin (trastuzumab) to improve disease-free survival (DFS) in HER-2 positive breast cancer patients after adjuvant chemotherapy, have shown that Herceptin affords a significant survival advantage.

1 Nov 2005

Novel mouse model of medulloblastoma

A collaboration of researchers, led by Dr. Martine Roussel of St. Jude Children's Research Hospital, has developed a novel mouse model of medulloblastoma -- the most prevalent malignant pediatric brain tumor -- that the researchers hope will more accurately represent the genetic changes involved in human brain tumor development.

30 Oct 2005

Rimonabant appears to be very promising, especially for the treatment of patients with abdominal obesity

Overweight or obese people who are stout around the waist and abdomen are particularly at high risk for developing type 2 diabetes and high blood pressure.

30 Oct 2005

Scientists find key step in a signaling pathway that helps orchestrate embryonic development

The study, reported in Nature (Oct. 13, 2005), focuses on the Hedgehog family of signaling molecules, which play a central role in directing development of the early embryo's growth and spatial plan, as well as its later organ and limb development. Defects in Hedgehog signaling are a significant cause of some birth defects and cancers.

25 Oct 2005

Lack of gene expression associated with ovarian cancer

The expression of two specific genes is almost completely downregulated in ovarian cancer tumours. An extensive analysis of gene expression in ovarian cancer tumour cells has revealed this important finding, which should be an aid to early diagnosis.

24 Oct 2005

NK-1 receptor antagonists very effective at reducing vomiting after surgery

The results of a new Phase III clinical trial have demonstrated that a new class of drugs, called "NK-1 receptor antagonists," is more effective at reducing vomiting after surgery than the most commonly used drug, according to the Duke University Medical Center researchers who led the trial.

24 Oct 2005

Survival benefits of longer-term tamoxifen use may take years to appear

The survival benefits of longer-term therapy using tamoxifen may take at least nine years to develop, according to a new study published in the December 1, 2005 issue of Cancer, a peer-reviewed journal of the American Cancer Society.

24 Oct 2005

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Carbon nanoparticles - both those unleashed in the air by engine exhaust and the engineered structures thought to have great potential in medical applications - promote blood-clotting, scientists report in an upcoming edition of the British Journal of Pharmacology.

23 Oct 2005

Discovery of a new kind of messenger RNA molecule

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection.

20 Oct 2005

Identification of a factor in human milk that can block HIV-1 transmission

Mother to child transmission of HIV accounts for a large proportion of HIV infections in children, with many infected as a result of breastfeeding, which requires transfer of the virus across mucosal barriers. DC-SIGN, a DC lectin receptor, interacts with HIV and is found at high expression levels in tonsillar tissue.

20 Oct 2005

Herceptin results "quite remarkable"

The targeted drug trastuzumab, or Herceptin, previously shown to prolong survival in advanced breast cancer, dramatically reduced the chances of recurrence in patients with early-stage disease when given for one year following standard chemotherapy.

19 Oct 2005

Hormone responsible for types of high blood pressure could also cause preeclampsia

Researchers at the University of Cincinnati (UC) Academic Health Center have found evidence of a hormone they say is responsible for certain types of high blood pressure (hypertension), and could also cause preeclampsia, a potentially dangerous condition that occurs during pregnancy.

17 Oct 2005

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

The finding has substantial clinical significance, as mutations in these cell survival-signaling pathways are associated with many human cancers, and a better understanding of how these pathways converge to regulate the delicate balance between cell proliferation and cell death may lead to development of more effective cancer therapies.

17 Oct 2005

New genetic discovery may help explain why some people develop high blood pressure and others don't

It also gives new insight into how the kidneys govern the balance of salt in the body, a crucial task for regulating blood pressure. And, it reveals how a gene already linked to behavior and mental health can play a role in the body, as well as the brain.

17 Oct 2005

Ethnic differences in cardiovascular risk factors

Heredity plays a major role in determining the blood lipid profile and heart rate variability of blacks and whites, two major risk factors for coronary artery disease, researchers say.

16 Oct 2005

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor -viral RNA interactions

Progressive disease after HIV infection is inversely correlated with the presence of plasmacytoid dendritic cells (pDCs), a subset of the dendritic cell family and the major producers of type 1 interferon in the body. High numbers of pDCs is related to successful control of HIV.

13 Oct 2005

Newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins

A newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins, such as vitamins A, E, and D, according to a new study in the October 2005 issue of Cell Metabolism.

11 Oct 2005

Receptor News and Research

Role of alpha tocopherol associated protein in prostate cancer

EphA2 represents a promising treatment target for glioblastoma multiforme

Bumetanide may help treat seizures in newborns

First study to confirm the benefit of anti-angiogenic therapy in patients with breast cancer

Novel mouse model of medulloblastoma

Rimonabant appears to be very promising, especially for the treatment of patients with abdominal obesity

Scientists find key step in a signaling pathway that helps orchestrate embryonic development

Lack of gene expression associated with ovarian cancer

NK-1 receptor antagonists very effective at reducing vomiting after surgery

Survival benefits of longer-term tamoxifen use may take years to appear

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Discovery of a new kind of messenger RNA molecule

Identification of a factor in human milk that can block HIV-1 transmission

Herceptin results "quite remarkable"

Hormone responsible for types of high blood pressure could also cause preeclampsia

Study identifies molecular switch that integrates cell survival signals from multiple intracellular signaling pathways

New genetic discovery may help explain why some people develop high blood pressure and others don't

Ethnic differences in cardiovascular risk factors

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor -viral RNA interactions

Newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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