Preclinical News and Research

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AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

AdvanCell, a radiopharmaceutical company developing a pipeline of Targeted Alpha Therapies for cancer patients, today announced the first patient was treated with 212Pb-ADVC001, a Targeted Alpha Therapy in development for the treatment of PSMA-positive metastatic Castration-Resistant Prostate Cancer (mCRPC).

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Preclinical research points to a promising new treatment option for pancreatic cancer patients

Preclinical research published in the Journal for ImmunoTherapy of Cancer points to a promising new treatment option for people with pancreatic cancer.

10 Nov 2023

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Andrew Buchanan on the Future of Biologics and AI

10 Nov 2023

Preclinical discovery could point the way toward better treatments for type 2 diabetes

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators.

9 Nov 2023

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, and Bio Farma, a biotechnology company based in West Java, Indonesia, announced today that Bio Farma's Bio-TCV typhoid conjugate vaccine (TCV) was licensed in Indonesia following marketing approval from Badan Pengawas Obat dan Makanan (BPOM), the national regulatory authority.

9 Nov 2023

Gamma delta T cells engineered to be more potent and long-lasting against cancer

UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for "off-the-shelf" cell therapy to treat challenging cancers.

8 Nov 2023

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes.

8 Nov 2023

PET scans of the heart identify people at risk for Parkinson's and Lewy body dementia

In a small study, researchers at the National Institutes of Health have found that positron emission tomography (PET) scans of the heart may identify people who will go on to develop Parkinson's disease or Lewy body dementia among those at-risk for these diseases.

7 Nov 2023

UTHSC's drug candidate for advanced prostate cancer goes to first clinical trial

A drug candidate developed by researchers at the University of Tennessee Health Science Center for advanced metastatic castration-resistant prostate cancer is now in its first clinical trial.

6 Nov 2023

Unraveling the role of HER2 mutant alleles in breast cancer

A new editorial paper was published in Oncotarget's Volume 14 on October 31, 2023, entitled, "The uncharted role of HER2 mutant alleles in breast cancer."

6 Nov 2023

CEPI and University of Oxford launch new project to initiate vaccine development against Junín virus

The Coalition for Epidemic Preparedness Innovations (CEPI) and the University of Oxford today announced the launch of a new project to initiate early development of prototype vaccines against the Junín virus, selected as an exemplar of the Arenavirus family which is responsible for multiple deadly hemorrhagic fevers with epidemic and pandemic potential.

6 Nov 2023

Overcoming T-cell exhaustion: A new hope for CAR-T cell therapy

CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful.

6 Nov 2023

New pathway to combat cardiovascular disease identified

Research led by the University of Minnesota Medical School identified a new pathway to combat cardiovascular disease. The study was recently published in Nature Cardiovascular Research.

3 Nov 2023

Modifying the gut microbiota can ameliorate hypertensive kidney damage and inflammation

New research in rodents indicates that altering gut microbes may affect the development of organ damage associated with hypertension.

2 Nov 2023

Researchers discover new mechanism of cancer treatment resistance

A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators.

2 Nov 2023

CN Bio appoints Neil Rumbelow as Director of Product Development

CN Bio appoints Neil Rumbelow as Director of Product Development.

From CN Bio 2 Nov 2023

From Cells to Drugs: How Cell Painting is Transforming Drug Discovery

In this interview, Jordi Carreras delves into the fascinating world of Cell Painting, a powerful technology gaining momentum in drug discovery. He shares insights into his groundbreaking research, the unique aspects of Phenaros' drug discovery platform, and the synergy between academia and industry.

From ELRIG (UK) Ltd. 1 Nov 2023

Researchers develop new method for mapping how the parts of the brain "speak" to each other

A research team led by Cleveland Clinic and Oregon Health and Science University (OHSU) has developed a new method for mapping how the parts of the brain "speak" to each other, critical to understanding behavior changes in patients with neurological disease.

31 Oct 2023

Next-generation vaccine candidates protect against multiple strains of influenza and last longer

Recent preclinical results indicate novel next-generation vaccine candidates developed at Cleveland Clinic protect against multiple strains of influenza and last longer than vaccines currently in use.

31 Oct 2023

Preclinical News and Research

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Preclinical research points to a promising new treatment option for pancreatic cancer patients

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Preclinical discovery could point the way toward better treatments for type 2 diabetes

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

Gamma delta T cells engineered to be more potent and long-lasting against cancer

Diabetes breakthrough: Scientists uncover novel route to stimulate beta cell growth

PET scans of the heart identify people at risk for Parkinson's and Lewy body dementia

UTHSC's drug candidate for advanced prostate cancer goes to first clinical trial

Unraveling the role of HER2 mutant alleles in breast cancer

CEPI and University of Oxford launch new project to initiate vaccine development against Junín virus

Overcoming T-cell exhaustion: A new hope for CAR-T cell therapy

New pathway to combat cardiovascular disease identified

Modifying the gut microbiota can ameliorate hypertensive kidney damage and inflammation

Researchers discover new mechanism of cancer treatment resistance

CN Bio appoints Neil Rumbelow as Director of Product Development

From Cells to Drugs: How Cell Painting is Transforming Drug Discovery

Researchers develop new method for mapping how the parts of the brain "speak" to each other

Next-generation vaccine candidates protect against multiple strains of influenza and last longer

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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