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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered ACE2 to enhance its affinity to RBD in human cells.

17 Sep 2020

Blood protein test could detect severity of head trauma in minutes

A blood protein test could detect the severity of head trauma in under 15 minutes, according to research published recently in the Journal of Neurotrauma.

17 Sep 2020

Researchers identify cause for thrombosis in COVID-19 patients

A new University of Kentucky College of Medicine study may provide answers for why so many COVID-19 patients experience thrombosis, or the formation of blood clots that obstruct blood flow through the circulatory system.

17 Sep 2020

Glucagon resistance: A new biological concept in the fight against diabetes

Researchers from the University of Copenhagen are introducing a new biological concept in the fight against diabetes: glucagon resistance.

17 Sep 2020

Biomarker predicts disease severity in COVID-19 patients

Airway cell analyses showing an activated immune axis could pinpoint the COVID-19 patients who will most benefit from targeted therapies.

17 Sep 2020

New drug candidate suppresses SARS-CoV-2 replication

Researchers at Stanford University and Utah State University have developed a novel inhibitor of the coronavirus main protease (Mpro) that effectively suppresses the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

Flexibility of glycosylated membrane-bound ACE2 suggests mechanical energy source in opening of SARS-CoV-2 spike

Angiotensin, Angiotensin-Converting Enzyme 2, Cell, Coronavirus, Enzyme, Glycoprotein, Neck, Protein, Receptor, Respiratory, Severe Acute Respiratory, Severe Acute Respiratory Syndrome, Syndrome, Virus, SARS-CoV-2, Coronavirus Disease COVID-19,

17 Sep 2020

Could pineapples be a new weapon against COVID-19?

Results of a recent research endeavor from the United States indicate that bromelain or bromelain rich pineapple stem may be utilized as an antiviral agent against coronavirus disease (COVID-19), but also for potential future coronavirus outbreaks. This exciting paper is currently available on the bioRxiv preprint server.

17 Sep 2020

CNIC researchers uncover a mechanism explaining how macrophages regulate obesity

Macrophages are immune system cells. They are essential in the early response to infections, and they also have a key role in the proper functioning of our tissues and the regulation of obesity.

17 Sep 2020

Breadfruit flour found to be a healthy alternative to other starches for modern foods

A fruit used for centuries in countries around the world is getting the nutritional thumbs-up from a team of British Columbia researchers.

17 Sep 2020

Scientists identify new genetic cause of syndromic microcephaly

Greenwood Genetic Center researchers, in collaboration with scientists from Belgium, Spain, and Italy, have confirmed that variants in LMNB1 cause syndromic microcephaly with variable short stature, intellectual disability, and other neurological symptoms.

17 Sep 2020

Combined use of three drugs linked with lower lung cancer incidence and mortality

Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology.

17 Sep 2020

UTHSC professor receives $455,000 grant to study cause of aggressive prostate cancer

Ramesh Narayanan, PhD, professor in the Department of Medicine and the Division of Hematology and Oncology at the University of Tennessee Health Science Center, has received a $455,000 grant from the National Cancer Institute for a two-year study of the underlying cause of the development of aggressive prostate cancer in African American men.

17 Sep 2020

Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

After screening more than 3,500 FDA-approved drugs and small molecules, researchers at the Chinese Academy of Sciences found that ceftazidime, an antibiotic approved for use in treating pneumonia, binds to the receptors that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to in human cells.

17 Sep 2020

Study: Pleotropic drugs can have both favorable and unfavorable effects on cell growth, survival

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21.

17 Sep 2020

Optimal antibody combinations and Fc binding inhibit SARS-CoV-2 in vivo

A recent study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University and published on the preprint server bioRxiv in September 2020 shows that a combination of neutralizing antibodies with intact Fc effector function can effectively reduce the viral load and prevent infection.

17 Sep 2020

Study shows why bacterial cells behave differently on different types of surfaces

These results from studies in both experimental and theoretical physics may help to improve antibacterial surfaces. The research work was recently published in the journal 'Nanoscale'.

17 Sep 2020

Powerful 2D FFF system opens up new routes for separations

Postnova Analytics powerful EAF4 technology combines the principle of Electrical and Asymmetrical Flow Field-Flow Fractionation in just one system.

From Postnova Analytics 17 Sep 2020

Blood viscometers could help guide the treatment of Covid-19 patients

One of the biggest challenges facing medical teams treating Covid-19 patients is identifying which ones are likely to suffer the most extreme responses to the virus.

17 Sep 2020

Azelastine antihistamine inhibits SARS-CoV-2 infection in nasal tissue in vitro

In a study published on the bioRxiv preprint server, researchers from the University of Pécs, University of Vienna, and CEBINA GmbH, Vienna, show the ability of the antihistamine azelastine to inhibit SARS-CoV-2 infection in human nasal tissue in vitro.

16 Sep 2020