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Transthyretin protein levels linked to heart failure and mortality

Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have uncovered significant findings regarding the impact of transthyretin, or TTR, protein levels on heart disease risk.

29 Jul 2024

Deciphering miRNA-mediated regulation of liver regeneration: New insights

The liver, a vital organ involved in numerous essential physiological processes such as bile production, plasma protein synthesis, nutrient absorption, detoxification, vitamin storage, macronutrient metabolism, and immune support, has a remarkable regenerative capacity.

29 Jul 2024

Dogs with gallbladder disease shed light on human cystic fibrosis

A canine gallbladder disease that involves the accumulation of abnormal mucus similar to that seen in human cystic fibrosis (CF) patients is caused by improper expression of the gene associated with CF in humans.

29 Jul 2024

Advancing hepatic cell carcinoma treatment through mitochondrial DNA targeting

Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges.

29 Jul 2024

Understanding iron overload in β-thalassemia: Mechanisms, diagnosis, and treatments

β-Thalassemia is a genetic disorder characterized by reduced or absent synthesis of the beta chains of hemoglobin, leading to ineffective erythropoiesis and severe anemia.

29 Jul 2024

Study identifies non-statin cholesterol drugs with potential to lower liver cancer risk

Past studies have suggested that taking cholesterol-lowering statin drugs may lower individuals' risk of developing liver cancer.

29 Jul 2024

New study reveals how colorectal cancer cells establish liver metastases

Researchers at ETH Zurich have uncovered how colorectal cancer cells colonize the liver. Their findings could open up new ways to suppress this process in the future.

29 Jul 2024

Revolutionizing hepatocyte count for researchers

In this interview, NewsMedical speaks to DeNovix's Dan Schieffer about the new app developed for CellDrop, and how it aims to revolutionize hepatocyte count for the drug discovery industry, and more.

From DeNovix Inc. 29 Jul 2024

GLP-1-based polyagonists: A promising weight loss alternative to bariatric surgery

Researchers highlight the unprecedented success of GLP-1-based multi-receptor drugs in achieving substantial weight loss and improved health outcomes, potentially replacing bariatric surgery for obesity treatment.

28 Jul 2024

Eight-week vegan diet linked to epigenetic age reduction in identical twins

Eating a vegan diet for eight weeks is associated with reductions in biological age estimations based on levels of DNA methylation - a type of chemical modification of DNA (known as an epigenetic modification) that alters gene expression but not DNA itself.

28 Jul 2024

Inflammation may not be key to fighting liver fibrosis in MAFLD

Researchers at UCLA Health uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to 40 percent of U.S. adults. While inflammation in the liver has long been considered a prerequisite to developing liver fibrosis, the scarring and thickening of tissue that can impair the liver's ability to function, this new research suggests that reducing inflammation may not influence the extent of fibrosis.

27 Jul 2024

Experimental cancer drug may help clear HIV from infected cells in the brain

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new Tulane University study.

25 Jul 2024

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

New study helps better understand the pathology of fatty liver disease MASH

A new study brings researchers closer to better understanding the pathology of the fatty liver disease MASH, which stands for metabolic dysfunction-associated steatohepatitis.

24 Jul 2024

Study unveils key mechanisms behind colorectal cancer metastasis to the liver

In cases where cancer is fatal, nine out of ten times the culprit is metastasis.

24 Jul 2024

Boosting ketone levels enhances heart function in mice with HFpEF, study shows

Increasing ketone supply to the heart in mice with heart failure with preserved ejection fraction (HFpEF) allowed their hearts to utilize more ketones and produce more energy, according to preliminary research presented today at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2024.

24 Jul 2024

Kaempferol's promise in fighting triple-negative breast cancer

Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.

24 Jul 2024

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

Why millions are trying FDA-authorized alternatives to big pharma’s weight loss drugs

Pharmacist Mark Mikhael has lost 50 pounds over the past 12 months. He no longer has diabetes and finds himself "at my ideal body weight," with his cholesterol below 200 for the first time in 20 years. "I feel fantastic," he said.

23 Jul 2024