Membrane News and Research

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Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

A recent study published in the Cell Reports journal analyzed immune ecology at the placenta in mild or asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy.

22 Jun 2022

New technology can revitalize the bactericidal effects of conventional antibiotics in MDR E.coli infections

A research team led by Professor Kelvin Yeung Wai-kwok from the Department of Orthopaedics and Traumatology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has designed a non-invasive technology to revitalize the bactericidal effects of conventional antibiotics in multidrug-resistant (MDR)Escherichia coli (E. coli)-associated deep tissue infections, such as urinary tract and peritoneal infections.

22 Jun 2022

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag's N-terminal matrix domain.

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

Researchers identify the role of TREM2-positive macrophages in non-alcoholic fatty liver disease

A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease.

21 Jun 2022

Clonal diversity impacts longevity of T cell reaction specific to SARS-CoV-2 epitope

A recent article under review at the Nature Portfolio journal and currently available on the Research Square* preprint server analyzed the factors influencing the durability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epitope-specific T cell reaction.

21 Jun 2022

Study uncovers novel treatment for chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (ChRCC) is a rare form of kidney cancer for which there are currently no proven treatments for metastatic or unresectable disease.

20 Jun 2022

Research may open door to the design of a better structured rabies vaccine

Rabies virus kills a shocking 59,000 people each year, many of them children. Some victims, especially kids, don't realize they've been exposed until it is too late.

17 Jun 2022

GPR183 gene a novel drug target for severe COVID-19

In a recent study posted to the bioRxiv* pre-print server, researchers provide the first preclinical evidence of the usefulness of antagonists of G-protein coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced gene 2 (EBI2), in reducing coronavirus disease 2019 (COVID-19) severity.

17 Jun 2022

Effectiveness of a hybrid vaccine against COVID-19 and influenza

Researchers assessed the efficiency of a hybrid vaccine against influenza and COVID-19 viruses.

16 Jun 2022

New component of cell death process could play key role in infection-fighting strategy

Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy.

16 Jun 2022

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

In a recent study posted to the bioRxiv* pre-print server, researchers illustrated the cryo-electron microscopic (cryo-EM) structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein in lipid nanodiscs to 3.5 angstroms (Å) resolution.

16 Jun 2022

Research reveals a potential Achilles heel in the protective layers surrounding Gram-negative bacteria

A new study published in Nature today has identified a potential Achilles heel in the protective layers surrounding Gram-negative bacteria that could aid in the development of next-generation antibiotics.

15 Jun 2022

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

Researchers assessed the probable efficacy of tea tree oil (TTO) as a natural disinfectant against SARS-CoV-2 using the human coronavirus OC43 (HCoV-OC43) and feline coronavirus (FCoVII) as surrogate models.

14 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022

Study identifies interesting sequence features in SARS-CoV-2 at start of COVID pandemic

In a recent study posted to the bioRxiv* pre-print server, researchers studied the sequence data from the coronavirus disease 2019 (COVID-19) cases from the Huanan seafood market in Beijing, China, to define the minor variant genome populations from the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pandemic.

14 Jun 2022

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

Orbit Discovery Ltd., (“Orbit”) a privately held biopharmaceutical company focused on discovering candidate peptide therapeutics harnessing proprietary affinity and cell-based functional screening platforms, has been awarded a Smart grant by Innovate UK, the UK’s innovation agency.

From Orbit Discovery 14 Jun 2022

The severity of COVID-19 compared to seasonal influenza

In a recent study under review at the Archives of Virology journal and currently posted to the Research Square* preprint server, investigators in Israel assessed the disparities and similarities between seasonal influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Jun 2022

Membrane News and Research

Even asymptomatic maternal COVID-19 can potentially cause pregnancy complications

New technology can revitalize the bactericidal effects of conventional antibiotics in MDR E.coli infections

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers identify the role of TREM2-positive macrophages in non-alcoholic fatty liver disease

Clonal diversity impacts longevity of T cell reaction specific to SARS-CoV-2 epitope

Study uncovers novel treatment for chromophobe renal cell carcinoma

Research may open door to the design of a better structured rabies vaccine

GPR183 gene a novel drug target for severe COVID-19

Effectiveness of a hybrid vaccine against COVID-19 and influenza

New component of cell death process could play key role in infection-fighting strategy

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

Research reveals a potential Achilles heel in the protective layers surrounding Gram-negative bacteria

The virucidal effects of tea tree oil against FCoVII and HCoV-OC43

The potential mechanisms of SARS-CoV-2 to induce DNA damage

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

Study identifies interesting sequence features in SARS-CoV-2 at start of COVID pandemic

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

The severity of COVID-19 compared to seasonal influenza

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