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Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

Researchers from the Department of Pathology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have identified a new metabolic mechanism in liver cancer cells, by which macropinocytosis, an endocytic process, is used to engulf extracellular proteins as fuels to support the unlimited growth of hepatocellular carcinoma (HCC) in hypoxia (oxygen deprivation).

14 Jun 2022

Stem cell-based therapy shows potential to provide blood sugar control in patients with high-risk type 1 diabetes

An investigative stem cell-based therapy called PEC-Direct, designed to act as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes, suggests a clinical study presented Saturday, June 11 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.

13 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

Creating CAR T cells without an immune brake

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells.

10 Jun 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Core body temperature increases host resistance to influenza virus and SARS-CoV-2 infection

A recent article posted to the Research Square* preprint server demonstrated that high body temperature elevates gut microbiota-reliant host resistance against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A viral infection.

10 Jun 2022

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

In a recent study posted to the medRxiv* pre-print server, researchers in the United Kingdom investigated the effect of two Pfizer/BioNTech BNT162b2 vaccine doses or Oxford/AstraZeneca AZ1222 coronavirus disease 2019 (COVID-19) vaccination and a subsequent BNT162b2 booster dose in a cohort of healthcare workers (HCWs) over six to nine months.

10 Jun 2022

Alternative remedy to conventional root canals would regenerate lost tooth pulp

Each year, dentists in the United States perform more than 15 million root canals on infected teeth, removing the inflamed pulp and filling the emptied canal with inert materials such as rubber and cement. What remains is a mineral shell in place of a living tooth.

9 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation exposure.

8 Jun 2022

Zoonotic origins of seasonal human coronaviruses

In a recent study posted to the bioRxiv* preprint server, investigators analyzed the evolution and origin of seasonal human coronaviruses (sHCoVs).

8 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

Where did Omicron's unique spike gene insertion originate?

In a recent study posted to the medRxiv* pre-print server, scientists at nference Labs investigated the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) new variant of concern (VOC) Omicron's unique spike (S) gene insertion ins214EPE.

8 Jun 2022

A new coronavirus found in Swedish bank voles

Researchers report the discovery of the Gimso virus, a novel betacoronavirus in a bank vole from Grimso, Sweden

7 Jun 2022

Sponge-like solar cells could form the basis for less-invasive pacemakers or similar medical devices

Holes help make sponges and English muffins useful (and, in the case of the latter, delicious). Without holes, they wouldn't be flexible enough to bend into small crevices, or to sop up the perfect amount of jam and butter.

7 Jun 2022

Study demonstrates how some fast-growing bacteria can evade antibiotic treatment

Scientists have demonstrated how some fast-growing bacteria can retreatment with antibiotics, according to a study published today in eLife.

7 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022

Age exacerbates COVID neuroimmunological symptoms

In a recent study posted to the bioRxiv* pre-print server, researchers at the University of Illinois at Chicago investigated whether aging exacerbated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced neuropsychiatric disorders.

6 Jun 2022

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to the Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.

6 Jun 2022

The effect of BNT162b2 mRNA COVID-19 vaccine on human semen

Scientists from Italy have recently analyzed the effect of the mRNA-based COVID-19 vaccine on the semen quality of adult men.

3 Jun 2022

Membrane News and Research

Targeting macropinocytosis may be an effective therapeutic approach for hepatocellular carcinoma

Stem cell-based therapy shows potential to provide blood sugar control in patients with high-risk type 1 diabetes

Deciphering the structure of nuclear pore complex piece by piece

Creating CAR T cells without an immune brake

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Core body temperature increases host resistance to influenza virus and SARS-CoV-2 infection

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

Alternative remedy to conventional root canals would regenerate lost tooth pulp

Study shines new light on the role of key Parkinson’s disease protein

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Zoonotic origins of seasonal human coronaviruses

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Where did Omicron's unique spike gene insertion originate?

A new coronavirus found in Swedish bank voles

Sponge-like solar cells could form the basis for less-invasive pacemakers or similar medical devices

Study demonstrates how some fast-growing bacteria can evade antibiotic treatment

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Age exacerbates COVID neuroimmunological symptoms

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

The effect of BNT162b2 mRNA COVID-19 vaccine on human semen

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