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Discovery of leptin-responsive neurons offers new hope for obesity treatment

Obesity affects a staggering 40 percent of adults and 20 percent of children in the United States. While some new popular therapies are helping to tackle the epidemic of obesity, there is still so much that researchers do not understand about the brain-body connection that regulates appetite.

5 Dec 2024

Anti-obesity medications could help treat alcohol use disorders

Losing weight with anti-obesity medications (AOM) also resulted in decreased alcohol consumption for about half of the participants in a new study appearing in the current issue of JAMA Network Open.

4 Dec 2024

New insights into survival of breast cancer cells in the bone marrow

A study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.

4 Dec 2024

Brain signature of resilience suggests a new way to recovery from trauma

Researchers at UCSF find a brain signature of resilience in mice that suggests a new way of treating severe depression.

4 Dec 2024

Ultrasound-controlled CRISPR offers precision in treating genetic disorders

Thanks to CRISPR, our medical specialists will soon have unprecedented control over how they treat and prevent some of our most challenging genetic disorders and diseases.

4 Dec 2024

New research sheds light on how monkeys avoid hepatitis B infection

Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases, that spreads among individuals through blood or body fluids.

4 Dec 2024

Biomarker discovery offers hope for aggressive breast cancer treatment

A new study led by Lund University in Sweden has solved a years-old mystery: which patients with aggressive breast cancer are helped by a targeted cancer treatment that had been under development but was shelved.

4 Dec 2024

New AI tool maps millions of CD8+ T cells to advance disease research

The scAtlasVAE model integrates scRNA-seq data to create a CD8+ T cell atlas, enhancing understanding of immune responses in inflammation and cancer.

4 Dec 2024

Cancer therapy may raise heart attack and stroke risks by disrupting immune regulation in arteries

Immune checkpoint inhibitors may heighten cardiovascular risks by altering immune interactions in atherosclerotic plaques, particularly in diabetic patients.

4 Dec 2024

Study shows lasting benefits of anti-hormonal therapy in postmenopausal women

Today, women with estrogen-sensitive breast cancer receive anti-hormonal therapy. Researchers now show that postmenopausal women with low-risk tumors have a long-term benefit for at least 20 years, while the benefit was more short-term for younger women with similar tumor characteristics who had not yet gone through the menopause.

3 Dec 2024

Polypurine hairpins found to effectively halt SARS-CoV-2 replication

A study led by the University of Barcelona and the Spanish National Research Council's Institute for Advanced Chemistry of Catalonia (IQAC - CSIC) presents a new therapeutic tool capable of inhibiting the proliferation of the SARS-CoV-2 virus that causes COVID-19.

3 Dec 2024

MIT engineers develop inflatable gastric balloon for weight loss

Gastric balloons - silicone balloons filled with air or saline and placed in the stomach - can help people lose weight by making them feel too full to overeat.

3 Dec 2024

Fas-p53 pathway drives metabolic dysfunction and obesity-linked insulin resistance

Researchers unveil Fas-p53 axis as a key regulator in adipocyte metabolism, linking it to obesity and insulin sensitivity through energy expenditure and inflammation pathways.

3 Dec 2024

Spatial transcriptomics uncovers new treatment paths for triple-negative breast cancer

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative breast cancer (TNBC). The findings identify nine spatial archetypes and gene signatures linked to immunotherapy response and patient outcomes.

2 Dec 2024

Boosting endocannabinoids could reduce opioid addiction risk

Increasing the levels of chemicals naturally produced in the body called endocannabinoids may thwart the highly addictive nature of opioids such as morphine and oxycodone while maintaining the drugs' ability to relieve pain, according to Weill Cornell Medicine investigators working with researchers from The Center for Youth Mental Health at NewYork-Presbyterian.

2 Dec 2024