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Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

An international team of researchers has found that three commonly used antiviral and antimalarial drugs are effective in vitro at preventing replication of SARS-CoV-2, the virus that causes COVID-19.

24 Mar 2021

Living guidelines for stroke management can guide clinical practice, improve patient outcomes

Clear guidelines about effective rehabilitation techniques for leg and arm weakness after stroke have been introduced, providing greater direction for health professional and improved patient outcomes.

24 Mar 2021

Researchers unveil world’s first smart monitoring system for the aged care industry

Pioneering technology that can deliver real-time and non-invasive resident monitoring and alerts for the aged care industry has been unveiled.

23 Mar 2021

‘Press 1 for English’: Vaccination sign-ups prove daunting for speakers of other languages

In late February, a week after Virginia launched a centralized website and call center for covid-19 vaccine preregistration, Zowee Aquino alerted the state to a glitch that could prove fatal for non-English speakers trying to secure a shot.

23 Mar 2021

SARS-CoV-2 infection is circadian

An international team of researchers has found that angiotensin-converting enzyme 2 (ACE2) levels in lung cells vary over the day, affecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The virus entry and replication in the lung cells also have a rhythmic cycle, suggesting circadian processes can affect the virus's life cycle.

22 Mar 2021

AI-based system for real-time prediction of complications in intensive care units

Life-threatening situations occur time and again in an intensive care unit. To make sure that doctors can intervene in time, a team at the German Heart Center Berlin has developed AI-based software that regularly evaluates all monitoring data and alerts staff before a critical situation is reached.

22 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New preclinical research led by Wensheng Wei from Peking University in China has proposed the development of a circular RNA vaccine. Their findings showed the circular RNA vaccine creates neutralizing antibodies and strong T-cell responses against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

21 Mar 2021

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.

19 Mar 2021

Identifying druggable targets on an essential SARS-CoV-2 protein

In a research paper recently uploaded to the preprint server bioRxiv by Newman et al. (March 15th, 2021) the structure and role of one such protein: NSP13, is investigated, with two appealingly druggable targets being identified, possibly opening a new route towards a novel SARS-CoV-2 antiviral agent.

18 Mar 2021

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

A new study published on the bioRxiv server focuses on the role of S-acylation in the SARS-CoV-2 infection cycle. It has also characterized Spike acylation and has also identified other acylated viral proteins and host enzymes involved in the process of infection. Further, it has also revealed the importance of acylation in viral biogenesis and infection.

18 Mar 2021

CN Bio introduces the PhysioMimix™ OOC Multi-Organ Microphysiological System

CN Bio today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS.

From CN Bio 17 Mar 2021

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

A discovery by University of Queensland pain researchers may allow some future cancer patients, including children with leukemia, to avoid their chemotherapy's worst and most debilitating side effects.

15 Mar 2021

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

In a recent bioRxiv preprint research paper, Botond Z. Igyártó and colleagues from Thomas Jefferson University demonstrated the inflammatory nature of the lipid nanoparticles (LNPs).

15 Mar 2021

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Researchers have found that SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment. Therefore, strategies such as focusing on limiting the production of IFN, rather than its function, could restrict the mechanism of SARS-CoV-2 that increases its viral load with delayed or absent symptoms.

12 Mar 2021

Early tracheotomy shortens ICU stay and lowers risk of ventilator-associated pneumonia

Surgically opening the windpipe, or trachea, within the first seven days of the start of mechanical ventilation decreases the time patients spend on ventilators, shortens their ICU stay and lowers their risk of ventilator-associated pneumonia, according to a systematic review published Thursday (March 11) in JAMA Otolaryngology-Head & Neck Surgery.

11 Mar 2021

Survey shows that 43% of respondents have already tested for coronavirus

According to the current BfR-Corona-Monitor of the German Federal Institute for Risk Assessment (BfR), 43 percent of the respondents have already had themselves tested for the virus.

10 Mar 2021

Study reveals novel approach to reduce the risk of thrombosis by using IgM antibodies

Thrombotic occlusion of blood vessels, which leads to myocardial infarctions, strokes and venous thromboembolisms, is the major cause of death in the western hemisphere.

9 Mar 2021

Study describes the infection of human cells by intestinal pathogen during spaceflight

Astronauts face many challenges to their health, due to the exceptional conditions of spaceflight. Among these are a variety of infectious microbes that can attack their suppressed immune systems.

9 Mar 2021

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

A new study, released as a preprint on the bioRxiv* server, reports an optimized coronavirus disease 2019 (COVID-19) vaccine candidate, which, claim the researchers, may be less likely to produce reactions like fevers. It may also have increased protective potential against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes COVID-19.

9 Mar 2021

Translation News and Research

Three commonly used antiviral drugs potentially effective at preventing replication of SARS-CoV-2

Living guidelines for stroke management can guide clinical practice, improve patient outcomes

Researchers unveil world’s first smart monitoring system for the aged care industry

‘Press 1 for English’: Vaccination sign-ups prove daunting for speakers of other languages

SARS-CoV-2 infection is circadian

AI-based system for real-time prediction of complications in intensive care units

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

Identifying druggable targets on an essential SARS-CoV-2 protein

The role of S-acylation in the enhancement of SARS-CoV-2 infectivity

CN Bio introduces the PhysioMimix™ OOC Multi-Organ Microphysiological System

Discovery may help cancer patients to avoid chemotherapy's debilitating side effects

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

SARS-CoV-2 is extremely sensitive to type I IFN pre-treatment, study finds

Early tracheotomy shortens ICU stay and lowers risk of ventilator-associated pneumonia

Survey shows that 43% of respondents have already tested for coronavirus

Study reveals novel approach to reduce the risk of thrombosis by using IgM antibodies

Study describes the infection of human cells by intestinal pathogen during spaceflight

Optimized SARS-CoV-2 vaccine candidate could be less reactogenic, say researchers

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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