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Understanding the human brain architecture through gene coexpression analysis

In a comprehensive Genomic Press Interview published in Brain Medicine, Dr. Michael C. Oldham shares his unconventional journey from advertising executive to computational neuroscientist and his groundbreaking contributions to understanding the human brain's cellular and molecular architecture through gene coexpression analysis.

8 Jul 2025

New RNA-based liquid biopsy detects early colorectal cancer with high accuracy

Liquid biopsies are tests that detect signs of cancer through a simple blood draw. Unlike traditional biopsies, which require removing a piece of tissue, a liquid biopsy typically looks for mutations or modification changes in fragments of DNA from cancer cells circulating in the blood.

8 Jul 2025

New funding brings personalized CRISPR cures closer to children with rare diseases

Personalized CRISPR cures for children born with rare genetic diseases are now a step closer to being more widely available.

8 Jul 2025

KAIST scientists develop tool to fight drug resistance in cancer

One of the biggest obstacles in cancer treatment is drug resistance in cancer cells. Conventional efforts have focused on identifying new drug targets to eliminate these resistant cells, but such approaches can often lead to even stronger resistance.

8 Jul 2025

Aspartame triggers genetic changes tied to glioblastoma severity

Study shows aspartame affects gut microbiome and gene expression in glioblastoma, highlighting potential links to cancer progression and treatment strategies.

8 Jul 2025

Scientists uncover hidden superfamily of lipid trapping proteins in bacteria

Scientists have identified a new type of protein in bacteria that could change our understanding of how these organisms interact with their environments.

8 Jul 2025

Landmark discovery reshapes understanding of key cancer protein MCL-1

Landmark research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some promising cancer treatments are causing serious side effects, and offers a roadmap for designing safer, more targeted therapies.

8 Jul 2025

Smallest known protein-based enzyme HARP reveals dual role in tRNA processing

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, the cell's protein-making factories.

7 Jul 2025

Retinal cells rewire to preserve vision in retinitis pigmentosa

Scientists at the Jules Stein Eye Institute at the David Geffen School of Medicine at UCLA have discovered that certain retinal cells can rewire themselves when vision begins to deteriorate in retinitis pigmentosa, a genetic eye disease that leads to progressive blindness.

7 Jul 2025

Corticosteroids may reduce effectiveness of immunotherapy in lung cancer

Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the disease, according to new research by Keck Medicine of USC.

7 Jul 2025

New AI-informed method accelerates protein engineering

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences has developed a groundbreaking method that could transform the field of protein engineering.

7 Jul 2025

Scientists discover key signal for artificial blood production

Scientists have been working on the artificial production of blood for several decades. Now, researchers from the University of Konstanz and Queen Mary University of London have taken an important step closer to that goal with a new discovery.

7 Jul 2025

Innovative bispecific antibody targets LAG-3 to treat autoimmune diseases

Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune diseases.

7 Jul 2025

New combination therapy inhibits tumor growth and blocks drug-induced resistance in ovarian cancer

A pairing of two experimental drugs inhibits tumor growth and blocks drug-induced resistance in ovarian cancer, according to a preclinical study led by Weill Cornell Medicine investigators.

7 Jul 2025

Researchers explore new therapies to prevent organ rejection without immunosuppressive drugs

While immunosuppressive medications are critical to prevent rejection of transplant organs, they also come with plenty of downsides.

7 Jul 2025

Neural stem cell grafts show promise for myelin repair in multiple sclerosis

A study led by Cambridge researchers has shed light on how neural stem cell grafts could help restore myelin in the central nervous system.

7 Jul 2025

Reversing immune fatigue offers new hope for cancer treatment

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the hostile and chronic environment of tumors, these cells often falter.

7 Jul 2025

Metabolic enzyme PHGDH found to play a surprising role in breast cancer immunity

Macrophages are immune cells with a split personality: some fight tumors, while others help them grow. In breast cancer, most macrophages fall into the latter camp—dubbed M2-like—fueling tumor progression and dampening immune responses.

7 Jul 2025

Synthetic Biology and the Pursuit of Living Diagnostics and Therapeutics

In this interview, Professor James J. Collins, founder of the field of Synthetic Biology, discusses his journey to founding the field of synthetic biology and the potential of living diagnostics.

From Pittcon 7 Jul 2025

Flavonoid diversity, not just quantity, drives better health outcomes

This study reveals that diverse flavonoid intake is crucial for lowering chronic disease risk and mortality, advocating for a varied diet rich in flavonoids.

7 Jul 2025