Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows

Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc., to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation.

14 Nov 2017

Adipocytes may reduce effectiveness of chemotherapeutic drug

Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment outcomes.

8 Nov 2017

New category of immunotherapy appears safe to use in patients with both cancer and HIV

A new category of immunotherapies called checkpoint inhibitors that has been highly effective against many different cancers appears safe to use in patients with both advanced malignancies and HIV, a population excluded from earlier trials of such therapies, according to an early-phase trial.

7 Nov 2017

Researchers to test use of ‘viral specific’ T-cells to target toxic viruses in children

Michael Pulsipher, MD, of the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, along with Michael Keller, MD from Children's National Health System in Washington, DC, have been awarded $4.8 million by the California Institute for Regenerative Medicine to study the use of a new T-cell therapy to help fight active viral infections in children with severe immune deficiencies.

7 Nov 2017

FDA grants approval to first treatment for rare blood cancer

The U.S. Food and Drug Administration today expanded the approval of Zelboraf (vemurafenib) to include the treatment of certain adult patients with Erdheim-Chester Disease (ECD), a rare cancer of the blood.

7 Nov 2017

FDA approves new drug Zelboraf for Erdheim-Chester disease

The United States Food and Drugs Administration (FDA) has approved Zelboraf (vemurafenib), a drug for the treatment of adults with a are type of blood cancer called Erdheim-Chester Disease or ECD.

6 Nov 2017

MRI scans of healthy military recruits reveal sacroiliac joint damage that mimics axial spondyloarthritis

The magnetic resonance imaging scans of healthy military recruits showed sacroiliac joint damage similar to that found in axial spondyloarthritis after just six weeks of intensive physical training, reinforcing the importance of exercising caution when interpreting MRI results, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego.

6 Nov 2017

Researchers develop new, three-step system to eliminate colorectal cancer

Researchers at Memorial Sloan Kettering Cancer Center in New York City and Massachusetts Institute of Technology in Boston have developed a new, three-step system that uses nuclear medicine to target and eliminate colorectal cancer.

2 Nov 2017

Conference to focus on preventing and reversing consequences of sickle cell disease

Leading experts in the field of sickle cell disease (SCD) research will convene in Washington, D.C., for the Physiological and Pathophysiological Consequences of Sickle Cell Disease conference (November 6–8). The conference, organized by the American Physiological Society, will explore SCD- the world's most prevalent single-gene mutation disease - and new research on preventing and reversing its deadly consequences.

1 Nov 2017

FDA grants accelerated approval to new treatment for mantle cell lymphoma

The U.S. Food and Drug Administration today granted accelerated approval to Calquence (acalabrutinib) for the treatment of adults with mantle cell lymphoma who have received at least one prior therapy.

1 Nov 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

Single infusion of wildtype HSPCs halts cellular damage caused by neuromuscular disorder in mice

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

25 Oct 2017

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

Researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia relapse.

25 Oct 2017

Research provides insight into how two stands of double helix separate during replication

Life would be impossible if the DNA in dividing cells were replicated with anything less than near-perfect precision. Every time a nucleated cell commits to becoming two cells, every "letter" of its genome must be replicated once and only once.

24 Oct 2017

New CAR-T cell therapy offers effective option for certain blood cancer patients

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers.

19 Oct 2017

Cascade of costs could push new gene therapy above $1 million per patient

Outrage over the high cost of cancer care has focused on skyrocketing drug prices, including the $475,000 price tag for the country's first gene therapy, Novartis' Kymriah, a leukemia treatment approved in August.

17 Oct 2017

Scientists develop revolutionary blood screening test to diagnose breast cancer

In a potential major breakthrough in breast cancer research, scientists at the Center for Translational Cancer Research at the Helen F. Graham Cancer Center & Research Institute of Christiana Care Health System have developed a revolutionary new blood test to diagnose breast cancer.

16 Oct 2017

Powering up fat cells could help acute myeloid leukemia patients

Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, according to a new study from McMaster University.

16 Oct 2017

Globus to build new protected cancer research networks for enhancing data security

With a $4.7 million grant from the National Cancer Institute, the University of Chicago's Globus and leading cancer researchers at University of Chicago Medicine will build new protected cancer research networks that enable collaborations while keeping sensitive health data secure and private.

13 Oct 2017

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

New potential biomarkers and a novel algorithm could help identify patients at increased risk of suffering from severe neurotoxicity after receiving CD19 CAR T-cell therapy. The study extensively characterized common and occasionally fatal side effects of this immunotherapy.

12 Oct 2017

Bone Marrow News and Research

Further Reading

Monoclonal antibody effectively blocks development of graft-versus-host disease, research shows

Adipocytes may reduce effectiveness of chemotherapeutic drug

New category of immunotherapy appears safe to use in patients with both cancer and HIV

Researchers to test use of ‘viral specific’ T-cells to target toxic viruses in children

FDA grants approval to first treatment for rare blood cancer

FDA approves new drug Zelboraf for Erdheim-Chester disease

MRI scans of healthy military recruits reveal sacroiliac joint damage that mimics axial spondyloarthritis

Researchers develop new, three-step system to eliminate colorectal cancer

Conference to focus on preventing and reversing consequences of sickle cell disease

FDA grants accelerated approval to new treatment for mantle cell lymphoma

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

Single infusion of wildtype HSPCs halts cellular damage caused by neuromuscular disorder in mice

Researchers develop new way to genetically engineer T cells for treating leukemia relapse

Research provides insight into how two stands of double helix separate during replication

New CAR-T cell therapy offers effective option for certain blood cancer patients

Cascade of costs could push new gene therapy above $1 million per patient

Scientists develop revolutionary blood screening test to diagnose breast cancer

Powering up fat cells could help acute myeloid leukemia patients

Globus to build new protected cancer research networks for enhancing data security

Study provides detailed characterization of neurotoxicity arising from CD19 CAR T-cell therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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