Mouse Model News and Research

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Study could offer a new way to treat Type 1 and Type 2 diabetes

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study.

1 Mar 2021

Study shows how D614G variant gains upper hand over original SARS-CoV-2 virus

Prior to the emergence of new mutants of the coronavirus, such as the British variant B.1.1.7, the SARS-CoV-2 variant named D614G had already mutated from the original SARS-CoV-2 pathogen that triggered the pandemic.

27 Feb 2021

Combination of deep brain stimulation and exercise has potential benefits for treating ataxia

New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement.

27 Feb 2021

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

27 Feb 2021

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s

Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer's disease (AD) and appears in approximately 90% of all patients.

25 Feb 2021

Repetitive compression of limbs may improve recovery from the most deadly stroke

Scientists want to know more about how an inexpensive, low-risk treatment may improve recovery from the most deadly type of stroke.

25 Feb 2021

Novel vectors reduce the risks associated with ocular gene therapies

Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development.

22 Feb 2021

A promising strategy to improve functional capacity of damaged muscle

Muscle is the largest organ that accounts for 40% of body mass and plays an essential role in maintaining our lives.

21 Feb 2021

Low-frequency brain stimulation prevents seizures in mice with temporal lobe epilepsy

Epileptic activity originating from one or more diseased brain regions in the temporal lobe is difficult to contain.

20 Feb 2021

Inhibitors to target SARS-CoV-2 viral protein display strong antiviral activity in transgenic mouse model

Inhibitors based on approved drugs and designed to disrupt the SARS-CoV-2 viral protein Mpro display strong antiviral activity both in vitro and in a transgenic mouse model, a new study reports.

18 Feb 2021

Blood-clotting protein linked with tumor pathogenesis of CNS B-cell lymphoma

In people with central nervous system (CNS) lymphoma, cancerous B cells--a type of white blood cell--accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels.

17 Feb 2021

Researchers identify molecular link between inflammatory signaling molecule and a main oncogene

A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection between an inflammatory signaling molecule and one of the main oncogenes.

17 Feb 2021

Probiotics may be beneficial in COVID-19 treatment

A new study explores the role of common probiotics in managing the disease, which could prove to be of great value, given the emergence of new variants and the broad spectrum of clinical disease in COVID-19.

17 Feb 2021

Asthma may influence the evolution of influenza virus, study shows

A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations.

16 Feb 2021

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Metabolic diseases, such as obesity and type 2 diabetes, have risen to epidemic proportions in the U.S. and occur in about 30 percent of the population. Skeletal muscle plays a prominent role in controlling the body's glucose levels, which is important for the development of metabolic diseases like diabetes.

16 Feb 2021

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

15 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

Mouse Model News and Research

Study could offer a new way to treat Type 1 and Type 2 diabetes

Study shows how D614G variant gains upper hand over original SARS-CoV-2 virus

Combination of deep brain stimulation and exercise has potential benefits for treating ataxia

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s

Repetitive compression of limbs may improve recovery from the most deadly stroke

Novel vectors reduce the risks associated with ocular gene therapies

A promising strategy to improve functional capacity of damaged muscle

Low-frequency brain stimulation prevents seizures in mice with temporal lobe epilepsy

Inhibitors to target SARS-CoV-2 viral protein display strong antiviral activity in transgenic mouse model

Blood-clotting protein linked with tumor pathogenesis of CNS B-cell lymphoma

Researchers identify molecular link between inflammatory signaling molecule and a main oncogene

Probiotics may be beneficial in COVID-19 treatment

Asthma may influence the evolution of influenza virus, study shows

Kruppel-like factor 15 controls skeletal muscle fat uptake and utilization

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

New mouse model of SARS-CoV-2 infection reflects features of human infection

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Study shows that SRC-3 also regulates human immune T regulatory cells

STING activation may be a new approach to reduce graft-versus-host disease

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