in vivo News and Research

RSS

Researchers evaluate atovaquone as a COVID-19 treatment

Researchers evaluated a drug, atovaquone, for COVID-19 treatment.

30 May 2022

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

Research of the laboratories led by Dr. Silvia de Santis and Dr. Santiago Canals, both from the Institute of Neurosciences UMH-CSIC (Alicante, Spain), has made it possible to visualize for the first time and in great detail brain inflammation using diffusion-weighted Magnetic Resonance Imaging.

27 May 2022

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Researchers compared the polymer-nanoparticle hydrogel system and standard routes of delivery of broadly neutralizing antibodies against SARS-CoV-2 in a mouse model.

27 May 2022

Scientists discover a gene defect that results in allergic and autoimmune disease

Inflammation of the skin and the esophagus, food allergy and asthma are just some of the symptoms of a now 12-year-old boy who was the first to have a mutation on the IL-33 gene. An international team led by a physician from the Karl Landsteiner University for Health Sciences, Krems, discovered this new disease entity.

26 May 2022

The role of pyroptosis in COVID-19

Researchers investigate the mechanisms by which SARS-CoV-2 induces NLRP3 inflammasome formation leading to pyroptosis.

25 May 2022

New imaging approach helps scientists build a complete picture of brain networks

Researchers at the Francis Crick Institute have developed an imaging technique to capture information about the structure and function of brain tissue at subcellular level – a few billionth of a metre, while also capturing information about the surrounding environment.

25 May 2022

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced its nomination of a novel preclinical candidate (PCC) targeting 3C-like (3CL) protease for the treatment of COVID-19.

24 May 2022

Novel ultrasound-assisted laser technique removes arterial plaque safely and efficiently

Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and chronic kidney disease and is traditionally treated by inserting and inflating a balloon to expand the artery.

24 May 2022

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Researchers assessed the neutralization efficacy of a saRNA vaccine targeting SARS-CoV-2 S protein against reinfection among hamsters with prior vaccination or infection.

24 May 2022

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

In a recent study posted to the medRxiv* preprint server, investigators in Singapore showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection elicited broadly specific virus-selective nasal resident CD8 and CD4 T cells.

24 May 2022

A digital twin for your immune system

In a recent study posted to the NPJ Digital Medicine journal, researchers illustrated a framework for constructing digital twins of the human immune system.

23 May 2022

UAB researchers track the behavior of microplastics inside a living organism

A UAB research team has managed to track the behavior of microplastics during their "journey" through the intestinal tract of a living organism and illustrate what happens along the way.

23 May 2022

Tiny shark-derived antibodies broadly neutralize most SARS-CoV-2 variants

Resarchers discuss the ability of shark-derived antibodies to protect against multiple variants of SARS-CoV-2.

23 May 2022

Can human coronaviruses infect the GI tract?

Researchers review current findings on how human coronaviruses like SARS-CoV-2 might cause GI symptoms.

22 May 2022

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

James Bibb, Ph.D., and colleagues have described a novel preclinical drug that could have the potential to combat depression, brain injury and diseases that impair cognition. The drug, which notably is brain-permeable, acts to inhibit the kinase enzyme Cdk5.

20 May 2022

Ensitrelvir demonstrates swift SARS-CoV-2 clearance and safety among individuals with asymptomatic, mild, or moderate SARS-CoV-2 infections

Researchers reported findings that assessed the safety and efficacy of Ensitrelvir among patients with asymptomatic or mild-to-moderate SARS-CoV-2 infection in Japan.

20 May 2022

in vivo News and Research

Researchers evaluate atovaquone as a COVID-19 treatment

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

A polymer-nanoparticle hydrogel to subcutaneously deliver broadly neutralizing antibodies against SARS-CoV-2

Scientists discover a gene defect that results in allergic and autoimmune disease

The role of pyroptosis in COVID-19

New imaging approach helps scientists build a complete picture of brain networks

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Insilico Medicine nominates novel preclinical candidate targeting 3CL protease for COVID-19 treatment

Novel ultrasound-assisted laser technique removes arterial plaque safely and efficiently

Hamster contact exposure challenge model assesses protection conferred by SARS-CoV-2 vaccination or prior infection against reinfection

Vaccinated individuals with SARS-CoV-2 infection develop virus-specific T cells inside their noses

A digital twin for your immune system

UAB researchers track the behavior of microplastics inside a living organism

Tiny shark-derived antibodies broadly neutralize most SARS-CoV-2 variants

Can human coronaviruses infect the GI tract?

Novel brain-permeable Cdk5 inhibitor alters neurobehavior in mice

Ensitrelvir demonstrates swift SARS-CoV-2 clearance and safety among individuals with asymptomatic, mild, or moderate SARS-CoV-2 infections

Glaucoma treatment using smart contact lenses that release drugs

Kyunurenic acid in cardiovascular therapy

SARS-CoV-2 zoonotic transmission prediction using ACE2 receptor variation is limited

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News