Calcium Channel Blocker News and Research

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New therapies could help type 1 diabetes care move beyond insulin alone

Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.

18 May 2026

ARB drugs lead to better blood pressure treatment adherence

Patients who start their blood pressure treatment with ARB drugs continue with the same medicine to a greater extent than patients who start out with other drugs.

22 Dec 2025

Single-pill combination medications may simplify treatment for adults with high blood pressure

Taking one pill that combines two or more blood pressure medications may help adults with high blood pressure (also known as hypertension) lower their blood pressure level faster and more effectively than taking multiple medications separately, and it may also reduce the risk of heart attack and stroke, according to a new scientific statement published today in the American Heart Association's journal Hypertension.

15 Dec 2025

Verapamil shows potential for preserving beta-cell function in type 1 diabetes

New research (the Ver-A-T1D trial) presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Vienna, 15-19 September) shows that slow-release (SR) verapamil (360mg daily) could have a potential effect on beta-cell function in adults with newly diagnosed type 1 diabetes.

18 Sep 2025

Phase II trial finds zilebesiran lowers systolic blood pressure in patients with uncontrolled hypertension

Among individuals with cardiovascular disease or high cardiovascular risk and uncontrolled hypertension on multiple anti-hypertensive agents, a single subcutaneous dose of zilebesiran 300 mg led to a 5-mmHg reduction in systolic blood pressure at Month 3 compared with placebo, a difference that did not reach statistical significance.

1 Sep 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025

Heart drug repurposed to kill hospital superbug Acinetobacter baumannii

A new study from Emory University addresses the growing global crisis of antibiotic-resistant infections. Many of these drug-resistant bacteria are spread through hospitals, and there are few antibiotics available for treatment.

10 Jun 2025

QUADRO trial demonstrates superior blood pressure control with four-in-one medication

A single-pill combination of four blood-pressure (BP)-lowering medications was significantly more effective than a combination of three medications, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

Home-administered nasal spray could be safely used to treat recurrent rapid heart rhythms

A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms.

9 Apr 2024

Calcium channel blockers reverse muscle weakness in animal model of myotonic dystrophy type 1

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these symptoms in animal models of the disease.

2 Jan 2024

Study points to senolytic drugs as potential weapon against lung emphysema

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema."

20 Dec 2023

Calcium channel blockers: A new hope for pregnant women with vasospastic angina

A woman with hopes to conceive was diagnosed with severe vasospastic angina (VSA); however, she was able to carry a healthy baby to full term without angina attacks after starting treatment of a calcium channel blocker, according to a case published in a special Cardio-Obstetrics issue of JACC: Case Reports.

6 Dec 2023

Early intervention key to managing diabetes, cardiorenal, and metabolic diseases

A panel of US-based experts in cardiology, nephrology, endocrinology, and primary care has prepared specific recommendations for early identification and intervention in obesity, diabetes, and other cardiorenal and metabolic diseases. A detailed report on recommended strategies has been published in the Journal of Diabetes and its Complications.

4 Jan 2023

Rare case of COVID-19 vaccine-induced hypophysitis in a woman with central diabetes insipidus manifestations

A new study to be published in the Therapies journal aimed to analyze a rare case of hypophysitis caused by pituitary stalk thickening three days following the administration of the SARS-CoV-2 vaccine.

11 Oct 2022

New insights into the link between EMFs, calcium and Alzheimer’s disease

For almost a quarter of a century, researchers have been studying and publishing on the effect of calcium on Alzheimer's Disease. Research has led to the development of the calcium hypothesis of Alzheimer's disease, which argues that Alzheimer's is caused by excessive intracellular calcium.

26 Apr 2022

Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions

A recent study posted to the medRxiv* preprint server investigated the association of renin-angiotensin-aldosterone system (RAAS)-mediated hypertension (HT) with coronavirus disease 2019 (COVID-19).

6 Apr 2022

Virtual population used to replicate a clinical trial that examines kidney damage in Black Americans

Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson. John S. Clemmer, PhD, a physiologist and lead author of the study, said his team model used a calcium channel blocker to predict kidney damage.

2 Apr 2022

Trial compares renal denervation to a sham procedure for treatment-resistant hypertension

Six-month outcomes from the randomized RADIANCE-HTN TRIO Trial comparing endovascular ultrasound renal denervation (RDN) to a sham procedure for treatment-resistant hypertension (HTN) found that the addition of a pharmacologic intervention led to further blood pressure reductions after RDN with a smaller increase in additional medications prescribed and less use of diuretics.

8 Nov 2021

Researchers survey repurposed drugs that inhibit SARS-CoV-2 replication in vitro

A new study by researchers at the University of Manchester, UK, reports on the compounds of interest that were identified as having potential for the treatment of COVID-19, from a library of almost 2,000 compounds from the APExBIO DiscoveryProbe library.

3 Feb 2021

Updated guideline on hypertrophic cardiomyopathy encourages shared decision-making

The American Heart Association and the American College of Cardiology today released an updated guideline for managing patients with hypertrophic cardiomyopathy (HCM).

22 Nov 2020