Cardiometabolic News and Research

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The obesity-microbiome story is more complicated than ‘good’ and ‘bad’ bacteria

This review finds that obesity is linked to reciprocal interactions between diet, the gut microbiome, microbial metabolites, and host metabolic pathways that influence appetite, insulin sensitivity, inflammation, and energy balance across the lifespan. It highlights diet as a particularly tractable way to influence this system, while emphasizing that microbiome changes associated with GLP-1 therapies remain difficult to separate from weight loss and that functional multi-omics approaches may help enable more personalized interventions.

3 Sep 2026

ACC Quality Summit 2026 to focus on cardiovascular patient care improvements

The American College of Cardiology (ACC) Quality Summit 2026 will take place on September 16-18 in Orlando, connecting the cardiovascular quality improvement community to share ideas, learn from real-world successes and drive measurable improvements in the quality, safety and value of patient care.

3 Sep 2026

Eight-year study reveals how molecular aging scripts differ individually

Aging does not appear to follow the same molecular script for everyone, according to an eight-year study of 335 women.

3 Sep 2026

Your weekend meal schedule may matter more than you think

In a prospective analysis of 104,806 adults from the NutriNet-Santé cohort, greater differences in meal timing between weekdays and weekends were associated with higher risks of cardiovascular disease and coronary heart disease in men over a median 8.1 years. The associations were strongest when weekend eating shifted earlier, while delayed weekend eating was linked specifically to coronary heart disease, with no association detected for cerebrovascular disease.

2 Sep 2026

Healthy ageing shaped by more varied biology than previously thought

Molecular changes of ageing are far more unique than previously thought, meaning two healthy individuals of identical age can experience significantly different ageing journeys.

2 Sep 2026

Semaglutide did more than cut weight in this analysis of 6,239 adults

A systematic review and meta-analysis of nine randomized controlled trials involving 6,239 adults with overweight or obesity without diabetes found that subcutaneous semaglutide produced substantially greater reductions in body weight, waist circumference, and C-reactive protein than placebo. The higher dose of 7.2 mg semaglutide showed potential for greater weight loss, although the evidence is largely based on a single trial and requires confirmation.

31 Aug 2026

New tool predicts heart failure treatment effects on blood pressure, kidney function and serum potassium

A new heart failure (HF) treatment effect calculator could help overcome one of the largest barriers to effective heart failure care by predicting the expected effects of treatment on blood pressure, kidney function and potassium levels.

31 Aug 2026

The scale told a similar story across three diets. The liver told a different one

In a randomized controlled trial of people with metabolically unhealthy obesity, approximately 10% weight loss improved insulin sensitivity and several cardiometabolic measures across ketogenic, Mediterranean, and very-low-fat plant-forward diets. However, the very-low-carbohydrate ketogenic diet produced larger improvements in hepatic insulin sensitivity and greater reductions in liver fat and several glucose and insulin measures than the higher-carbohydrate diets.

31 Aug 2026

Ketogenic diet excels at reversing prediabetes and fatty liver

There is no shortage of popular diets to try, and they can generally produce weight loss if followed to the letter. But are all diet plans created equal in terms of reducing the cardiometabolic risks that come with obesity, such as Type 2 diabetes and liver disease?

27 Aug 2026

Ketogenic diet provides greatest health benefits for treating obesity

A diet that severely limits carbohydrates but is high in fat has the greatest health benefits for people with obesity compared to a Mediterranean diet or a low-fat diet, according to a clinical trial publishing August 27 in the Cell Press journal Cell Metabolism.

27 Aug 2026

A year after women lost weight, researchers saw which health gains lasted and which faded

Diet-induced weight loss significantly reduced predicted 10-year risks of major adverse cardiovascular events and type 2 diabetes in healthy premenopausal women with overweight, regardless of whether aerobic or resistance exercise was added. Some of these gains diminished as weight was partially regained over the following year, although greater exercise adherence was associated with less rebound in predicted diabetes risk.

25 Aug 2026

Japan vaccinated heavily during COVID-19. Why are so many unsure about vaccinating next time?

A nationwide Japanese survey found that only 53.1% of respondents said they would accept vaccination in a hypothetical future pandemic with COVID-19-like fatality, despite substantially higher previous COVID-19 vaccine uptake. Willingness varied by demographics, perceived disease risk, exposure to misinformation, vaccine characteristics, and practical factors such as cost, evidence, professional recommendations, and accessibility.

24 Aug 2026

More coffee, higher testosterone? This study found a more complicated picture

Higher habitual coffee intake was associated with a leaner body composition, lower circulating branched-chain amino acids, and distinct cardiometabolic patterns in 2,264 middle-aged Finnish adults. Hormonal associations differed by sex, with broader testosterone- and SHBG-related patterns in men and more limited SHBG-related changes in women.

20 Aug 2026

New AI tool helps personalize care after heart attacks

The health of heart attack survivors follows three distinct paths in the five years after their health event, say researchers from the University of Surrey.

19 Aug 2026

Lower-calorie meals look cheaper, but there’s a catch in the price

Analysis of 7,392 menu items from 200 large restaurant chains found that lower-calorie options on two major UK food delivery platforms carried a substantially higher cost per 100 kcal than higher-calorie items. The findings suggest that per-calorie pricing may create financial disincentives for choosing lower-calorie foods, with potential implications for diet-related health inequalities.

19 Aug 2026

Whole grains, legumes and vegetables stand out in a major review of diabetes diets

Healthy plant-based diets rich in whole grains, legumes, fruits, vegetables, nuts, and seeds are associated with better glycemic control and a lower risk of type 2 diabetes. The review finds that food quality and processing matter more than simply avoiding animal foods, while unhealthy plant-based patterns and higher red and processed meat intake are associated with greater metabolic risk.

18 Aug 2026

A four-week spice experiment challenges expectations about post-meal benefits

Culinary doses of herbs and spices did not significantly alter postprandial endothelial function, glycemia, or lipemia after four weeks of corresponding spice-containing diets in adults at cardiometabolic risk. The findings suggest that acute spice-related effects may be less apparent with longer-term exposure, although the study may have been underpowered to detect modest benefits.

17 Aug 2026

Sprint exercise sends a very different molecular signal through the body

Sprint-interval exercise triggers a much larger and faster shift in circulating proteins and metabolites than moderate-intensity exercise, revealing distinct patterns of predicted communication between organs. The findings suggest that exercise intensity shapes systemic molecular signaling, with skeletal muscle and adipose tissue emerging as potential source and target tissues linked to cardiometabolic health.

16 Aug 2026

Three minutes of sprinting dramatically reshape molecular contents of the bloodstream

Three minutes of sprinting can do something that 90 minutes of moderate exercise apparently cannot: dramatically reshape the molecular contents of the bloodstream.

14 Aug 2026

Finnish study links habitual coffee consumption to healthier body metabolism

Coffee is one of the world's most widely consumed beverages, and previous research has linked its consumption to a lower risk of conditions such as type 2 diabetes and cardiovascular disease.

13 Aug 2026