Cholangiocarcinoma News and Research

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ECOG-ACRIN opens trial testing ivonescimab for aggressive bile duct cancer

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) announced today that it will open a randomized, registration-enabling phase 2/3 clinical trial to evaluate ivonescimab combined with chemotherapy as first-line treatment for patients with advanced biliary tract cancer (BTC).

21 Oct 2026

Bile DNA sequencing helps identify hidden pancreatobiliary tumors

Distinguishing malignant from benign biliary strictures remains a major clinical challenge. Endoscopic retrograde cholangiopancreatography (ERCP)-guided cytology and biopsy may be inconclusive, particularly in early-stage disease or when tissue is scarce.

29 Sep 2026

UCLA researchers present new radiation advances at ASTRO 2026

Physicians and scientists from the UCLA Health Jonsson Comprehensive Cancer Center will share new research and clinical trial findings at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, including studies on new treatment approaches for prostate, bile duct and head and neck cancers, personalized radiation therapy based on genetic risk, and advances in targeted radiation and radioligand therapy designed to improve cancer control while limiting treatment side effects.

25 Sep 2026

Blood test detects more cancers when added to standard screening

A single blood draw that screens for more than 50 cancers substantially increased cancer detection when added to standard screening, identifying cancers that otherwise might have gone undetected until later stages, according to a new study from the Oregon Health & Science University Knight Cancer Institute.

22 Sep 2026

Tuft cell-like cancers exhibit unique biological characteristics across multiple organs

A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized.

6 Aug 2026

Targeted therapy doubles progression-free survival in rare bile duct cancer

Results of the ongoing eNRGy trial, a single-arm, multicenter, global phase 2 clinical trial evaluating zenocutuzumab in solid tumors positive for Neuregulin 1 (NRG1) gene fusions, reported manageable side effects and clinically meaningful efficacy – including a near doubling of progression-free survival compared to expectations with standard of care – in previously treated patients with advanced NRG1-positive cholangiocarcinoma.

2 Jul 2026

New AI framework outperforms conventional biomarkers in predicting cancer survival

Digestive system cancers, including hepatobiliary and gastrointestinal malignancies, remain a major global oncological burden. Although immune checkpoint inhibitors have changed the treatment landscape for some patients, their overall efficacy remains limited, with only about 15% to 30% of patients achieving durable clinical benefit.

1 Jul 2026

Trial shows safety of novel KIR-CAR T therapy in solid tumors

An innovative type of CAR T cell therapy, called KIR-CAR, was shown to be safe, with increasing efficacy corresponding to higher doses of the investigational treatment in nine patients with advanced ovarian cancer, mesothelioma or cholangiocarcinoma (bile duct cancer), according to an early report from an ongoing Phase I dose-escalation clinical trial.

20 Apr 2026

New roadmap links liver cancer biology to immunotherapy and precision medicine

A new review from the Icahn School of Medicine at Mount Sinai and the Hospital Clínic de Barcelona provides one of the clearest roadmaps to date for understanding and treating liver cancer, one of the deadliest cancers worldwide.

17 Apr 2026

High-dose radiation improves survival in large bile duct tumors

A new study from researchers at The University of Texas MD Anderson Cancer Center demonstrates that a specialized high-dose type of radiation delivery may significantly improve outcomes for patients with large bile duct tumors in the liver, known as intrahepatic cholangiocarcinoma.

2 Apr 2026

Cholangiocarcinoma News and Research

ECOG-ACRIN opens trial testing ivonescimab for aggressive bile duct cancer

Bile DNA sequencing helps identify hidden pancreatobiliary tumors

UCLA researchers present new radiation advances at ASTRO 2026

Blood test detects more cancers when added to standard screening

Tuft cell-like cancers exhibit unique biological characteristics across multiple organs

Targeted therapy doubles progression-free survival in rare bile duct cancer

New AI framework outperforms conventional biomarkers in predicting cancer survival

Trial shows safety of novel KIR-CAR T therapy in solid tumors

New roadmap links liver cancer biology to immunotherapy and precision medicine

High-dose radiation improves survival in large bile duct tumors

Gene signature maps cholangiocarcinoma subtypes for precision treatment

New genetic ‘roadmap’ advances precision therapy for intrahepatic cholangiocarcinoma

Experts call for rapid improvements in diagnosis, treatment of bile duct cancer

Diagnostic prognostic and therapeutic relevance of PIVKA-II in hepatocellular carcinoma

Blood test identifies colon cancer patients who benefit from anti-inflammatory medication

FOLFIRINOX shows promise as a second-line option for advanced biliary tract cancer

After series of denials, his insurer approved doctor-recommended cancer care. It was too late.

E2F2 protein identified as potential therapeutic target to prevent metabolic fatty liver disease progression

New method uncovers how extracellular vesicles impact immune response in cancer

International commission calls for action against hepatocellular carcinoma

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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