Frontotemporal Dementia News and Research

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Scientists traced a hidden immune route that may worsen tau-linked brain damage

In a mouse model of tauopathy, conventional type 1 dendritic cells (cDC1s) cross-presented brain-derived antigens in deep cervical lymph nodes, priming CD8+ T cells that accumulated in the brain and promoted neurodegeneration. Disrupting cDC1s or their cross-presentation activity reduced CD8+ T-cell infiltration and protected against neuronal loss, while human primary tauopathy samples also showed increased brain CD8+ T cells, although cDC1 involvement in humans remains unconfirmed.

6 Sep 2026

Brain atrophy on MRI could help predict Alzheimer’s progression

Mass General Brigham Neuroscience Institute researchers have found that a pattern of brain atrophy visible on MRI could help predict how quickly people with early-onset Alzheimer's disease progress from mild cognitive impairment to dementia.

27 Aug 2026

Shared protein pathology redefines treatment for multiple neurodegenerative diseases

On the surface, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) might seem like unrelated diseases.

24 Aug 2026

Microglial differences found in genetic and sporadic frontotemporal dementia patients

A study by the University of Eastern Finland revealed for the first time clear differences in the function and gene expression of microglial cells from patients with genetic and sporadic types of frontotemporal dementia.

20 Aug 2026

New blood protein biomarkers estimate timing of ALS symptoms

Months to several years before amyotrophic lateral sclerosis (ALS) symptoms arise, levels of certain blood proteins may dramatically shift.

27 Jul 2026

Early-onset dementia lowers work productivity years before formal diagnosis

People diagnosed with early-onset dementia had reduced work productivity up to 15 years before diagnosis, according to a study published July 8, 2026, in Neurology, the medical journal of the American Academy of Neurology.

9 Jul 2026

Blood circRNAs may predict Alzheimer’s before symptoms emerge

Blood-based circular RNAs showed strong potential for identifying biomarker-confirmed Alzheimer’s disease and predicting progression to symptomatic disease. When combined with pTau217, the circRNA model produced the strongest predictive performance, but larger prospective validation is still needed.

2 Jul 2026

Discovery of karyoptosis opens new therapeutic targets for Alzheimer's and frontotemporal dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

25 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026

Common joint supplement may accelerate Alzheimer's disease progression

New research has found an association between taking glucosamine, a popular over-the-counter supplement used for joint pain, and a higher likelihood of progressing from mild cognitive impairment to Alzheimer's disease.

9 Jun 2026

Grant fuels research into SYNGAP1-linked behavioral abnormalities

CURE SYNGAP1 501(c)(3) is pleased to announce a $130,000 grant to Dr. Helen Willsey and Dr. David Kastner at the University of California, San Francisco (UCSF).

5 Jun 2026

Allen Institute launches global research initiative to accelerate new treatments for brain disorders

The Allen Institute, together with partner organizations, today launched the Brain Health accelerator: an ambitious global research initiative seeking to identify the specific brain cells and circuits affected in neurodegenerative disease and other brain disorders and use that knowledge to accelerate the development of new treatments.

2 Jun 2026

Uneven grey matter loss serves as a powerful new biomarker for early neurodegeneration

Universitat Oberta de Catalunya Alzheimer's disease begins to weave a web in the brain and remodel neuronal tissue 15 to 20 years before the first symptoms appear. From the time this happens, however, until the disease is diagnosed and, later, enters an advanced phase, it progresses along a continuum of changes to the brain.

21 May 2026

Frontotemporal Dementia News and Research

Scientists traced a hidden immune route that may worsen tau-linked brain damage

Brain atrophy on MRI could help predict Alzheimer’s progression

Shared protein pathology redefines treatment for multiple neurodegenerative diseases

Microglial differences found in genetic and sporadic frontotemporal dementia patients

New blood protein biomarkers estimate timing of ALS symptoms

Early-onset dementia lowers work productivity years before formal diagnosis

Blood circRNAs may predict Alzheimer’s before symptoms emerge

Discovery of karyoptosis opens new therapeutic targets for Alzheimer's and frontotemporal dementia

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

Common joint supplement may accelerate Alzheimer's disease progression

Grant fuels research into SYNGAP1-linked behavioral abnormalities

Allen Institute launches global research initiative to accelerate new treatments for brain disorders

Uneven grey matter loss serves as a powerful new biomarker for early neurodegeneration

Ultrasensitive test detects protein clumps to diagnose rare dementia subtype

New human cell model replicates key mechanisms of neurodegenerative diseases

Study explains failure of cellular cleanup in neurodegenerative diseases

Novel compound clears harmful protein, protects neurons in frontotemporal dementia models

New study identifies specific brain cells most vulnerable to ALS and dementia

Reducing miRNA levels helps rescue vascular defects in Rett syndrome

Study identifies link between gut bacteria and deterioration of the brain in ALS, dementia

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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